METABOLIC RESPONSE TO WESTERN VS INDIGENOUS DIETS IN HISPANIC WOMEN

西班牙裔女性对西方饮食与本土饮食的代谢反应

• 批准号: 7881264
• 负责人: Marian L Neuhouser
• 金额: $ 21.51万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881264
• 关键词: Address; Adipose tissue; Americas; Area; Beverages; Biological; Biological Markers; Biology; Bladder Diseases; Blood; Breast Cancer Risk Factor; C-reactive protein; Cancer Biology; Carbohydrates; Cardiovascular Diseases; Centers for Population Health; Characteristics; Chronic Disease; Complement; Complex; Country; DNA; Data; Deposition; Diabetes Mellitus; Diet; Diet Habits; Dietary Practices; Disadvantaged; Edible Plants; Education; Employment; Environmental Exposure; Etiology; Event; Fabaceae; Family; Fatty acid glycerol esters; Female; Fiber; Food; Food Patterns; Gallbladder; Generations; Genetic; Genetic Crossing Over; Genetic Variation; Genotype; Glucose; Goals; Health; Healthy People 2010; Hispanics; Human; Hunger; IGF1 gene; Immigrant; Income; Indigenous; Individual; Inflammation; Inflammatory; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Interleukin-6; Investigation; Laboratories; Latina; Lead; Leptin; Life; Malignant Neoplasms; Measures; Mediating; Metabolic; Metabolic Diseases; Mexican; Mexican Americans; Minority Groups; Morbidity - disease rate; Not Hispanic or Latino; Obesity; Obesity associated cancer; Participant; Pattern; Persons; Physiological; Population; Predisposition; Prevention; Prevention program; Protein C; Public Health; Randomized; Research; Resources; Risk; Role; Satiation; Screening procedure; Serum amyloid A protein; Social Environment; Somatomedins; Specimen; TNFRSF5 gene; Testing; United States; Urine; Whole Blood; Woman; abstracting; adiponectin; arm; cancer health disparity; cancer prevention; cancer risk; cost; design; effective intervention; feeding; fruits and vegetables; health disparity; low socioeconomic status; malignant breast neoplasm; meetings; metabolic abnormality assessment; mortality; nutrition; obesity risk; post intervention; prevent; response; social; trait

Abstract: This proposal focuses on understanding the relationship between dietary patterns and risk of obesity in Hispanic women. This is an important issue in the realm of health disparities because neariy 80% of Hispanic women in the United States are ovenweight or obese and obesity increases risk for numerous chronic diseases, including breast cancer. The overall goal of this project Is to test the metabolic response to Western -and Indigenous Mexican diets in Hispanic women. We will also investigate whether ancestral genetic variation mediates the response to each diet. We hypothesize that the biological response to a Western dietary pattern produces detrimental metabolic profiles favoring adipose deposition, which leads to increased risk of adverse health events, including increased risk of breast cancer. Conversely, we hypothesize that the physiologic response to an Indigenous Mexican diet will produce a favorable metabolic profile. We further hypothesize that genetic ancestry mediates this biological response to a Western dietary pattern. Our primary aims are: (1) To test in a randomized cross-over experimental feeding study the metabolic response to an Indigenous Mexican diet vs. a Western diet in 50 first and second generation Hispanic women living in the greater Seattle area. The metabolic response will be measured by blood concentrations ofthe following biomarkers assessed before and after each feeding period: insulin, glucose, IGFI, IGFBP3, leptin, adiponectin, IL-6, CRP and SAA; and (2) To investigate whether genetic characteristics, as assessed with Ancestry Informative Markers, mediate the metabolic response to each tested diet. As secondary alms we will examine measures of hunger and satiety during each diet test period and genetic predictors of adiposity. This project will provide important data for understanding the etiology of obesity in i-lispanic women, which can be used to design effective programs for prevention.

翻译后摘要：这项建议的重点是了解西班牙裔妇女的饮食模式和肥胖的风险之间的关系。这是健康差异领域的一个重要问题，因为美国近80%的西班牙裔妇女体重超重或肥胖，肥胖增加了许多慢性疾病的风险，包括乳腺癌。该项目的总体目标是测试西班牙裔妇女对西方和土著墨西哥饮食的代谢反应。我们还将研究祖先的遗传变异是否介导对每种饮食的反应。我们假设，对西方饮食模式的生物反应产生了有利于脂肪沉积的有害代谢特征，这导致不良健康事件的风险增加，包括乳腺癌风险增加。相反，我们假设对墨西哥土著饮食的生理反应将产生有利的代谢特征。我们进一步假设，遗传祖先介导这种生物反应，西方饮食模式。我们的主要目标是：（1）在一项随机交叉实验喂养研究中，在生活在大西雅图地区的50名第一代和第二代西班牙裔妇女中测试对土著墨西哥饮食与西方饮食的代谢反应。代谢反应将通过在每个喂养期之前和之后评估的以下生物标志物的血液浓度来测量：胰岛素、葡萄糖、IGFI、IGFBP 3、瘦素、脂联素、IL-6、CRP和SAA;以及（2）研究如用遗传学信息标志物评估的遗传特征是否介导对每种测试饮食的代谢反应。作为第二次施舍，我们将检查在每个饮食测试期间饥饿和饱腹感的测量以及肥胖的遗传预测因子。本研究将提供重要的资料，以了解西班牙裔妇女肥胖症的病因，并可用来设计有效的预防方案。