Infrastructure Support and Pilot Tissue Collection for the CARET Biorepository
CARET 生物样本库的基础设施支持和试点组织采集
基本信息
- 批准号:10374863
- 负责人:
- 金额:$ 59.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:All-Trans-RetinolAsbestosAwardBeta CaroteneBiocompatible MaterialsBiologicalBiological MarkersBiological Specimen BanksBiological Specimen databaseBiopsyCaliforniaCancer Prevention TrialCardiovascular DiseasesCaroteneCause of DeathCessation of lifeCharacteristicsCigarette SmokerClinicalClinical DataCollectionColon CarcinomaConnecticutConsentDNADataDatabasesDevelopmentDiagnosisDiagnosticDiagnostic Neoplasm StagingDiseaseEarly DiagnosisEndpoint DeterminationEnrollmentEtiologyExposure toFundingFunding MechanismsGoalsGovernmentGrantHuman ResourcesIncidenceInfrastructureInterventionIntervention TrialInvestigationLaboratoriesLife StyleMaintenanceMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of prostateMalignant neoplasm of urinary bladderMedical RecordsMicronutrientsMineralsMolecular EpidemiologyOccupational ExposureOperative Surgical ProceduresParentsParticipantPeer ReviewPersonsPhasePlasmaPopulationPopulations at RiskPositioning AttributePreventionProceduresPrognosisPublicationsPublishingRandomizedRecordsResearchResearch PersonnelResectedResourcesSafetySamplingScheduleSerumSiteSmoking HistorySpecimenStage at DiagnosisStructure of parenchyma of lungTimeTissue BanksTissue SampleTissuesTobaccoTumor TissueTwin Multiple BirthUnited States National Institutes of HealthUpdateVitaminsWashingtonWhole BloodWomanbiobankcancer diagnosiscancer epidemiologycancer preventioncigarette smokingcohortcostdata sharingdietarydouble-blind placebo controlled trialearly detection biomarkerseditorialefficacy trialfollow-upgenetic analysisgenetic epidemiologyhigh riskhigh risk populationimprovedindexingintervention effectmalignant breast neoplasmmenmolecular subtypesmortalityneoplasm registrynutritionnutritional epidemiologypersonalized medicinepost interventionpublic databaserecruitrepositoryresearch and developmentretinyl palmitatetobacco abusetooltumortumor heterogeneityweb site
项目摘要
Project Summary
The Carotene and Retinol Efficacy Trial (CARET) was a randomized, double-blind, placebo-controlled trial of
the cancer prevention efficacy and safety of a daily combination of 30 mg of β-carotene and 25,000 IU of
retinyl palmitate in 18,314 persons at high risk for lung cancer. The trial began recruitment in 1985 and was
halted in January 1996, 21 months ahead of schedule, with the twin conclusions of no benefit and substantial
evidence of a harmful effect of the intervention on both lung cancer incidence and total mortality. Participants
continued to be followed for over nine years post-intervention, with updated lung cancer incidence and
cardiovascular disease mortality findings published in 2004. On June 30, 2005, CARET stopped active follow-
up of participants. During the active intervention phase of CARET, serum, plasma, whole blood (for DNA), and
lung tissue specimens were collected. These biospecimens make up the CARET biorepository, which is the
focus of this application. The CARET biorepository is a key tool in studying disease development and
progression. It is an invaluable legacy of the parent trial with specimens available to any investigator with a
hypothesis-driven project.
The specific aims of the current grant cycle (2013-2018) included extending the database and online
accessibility to include participant use of micronutrient, mineral, and vitamin supplements; baseline laboratory
values; and stage at diagnosis of lung, prostate, colon, and breast cancer cases. We also extended CARET
follow-up of cancer diagnoses, deaths, and causes of death through 2012/13 via linkages to the National Death
Index, Cancer Registry of Connecticut, and the Cancer Registries of California and Washington. This has
greatly increased the total numbers of identified incident cancer cases (n=6,773) as well as extending the
follow-up of the entire cohort (median follow-up to first diagnosis is 18 years and to death is 20 years). In our
goal to make the CARET biorepository accessible, during the current grant cycle (2013 – 2018), biospecimens
and /or data have been provided to investigators, which have resulted in 23 peer-reviewed publications.
Currently there are 93 ongoing projects utilizing CARET biospecimens.
In this application, we request funds to continue support of the CARET biorepository and the associated
extensive database. We also propose to pilot procedures to obtain updated signed releases of medical records
and consent for the utilization of biologic material in the CARET biorepositories consistent with recent
developments on obtaining consent for broad research purposes and data sharing. In addition, to position
CARET for studies examining the association of tumor heterogeneity and molecular subtypes with etiologic
factors and survival, we propose to conduct a pilot to obtain diagnostic lung cancer biopsy/surgical specimens
from Washington State CARET participants diagnosed after 2003. This will include obtaining updated release
of medical records and consent for broad research purposes and data sharing.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Marian L Neuhouser其他文献
Investigating the impact of body composition on the estimation of resting metabolic rate: new equations for adults aged ≥65 years developed using cross-sectional data
探究身体成分对静息代谢率估算的影响:利用横断面数据推导出适用于65岁及以上成年人的新公式
- DOI:
10.1016/j.ajcnut.2024.12.023 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:6.900
- 作者:
Judi Porter;Leigh C Ward;Kay Nguo;Zoe Davidson;Simone Gibson;Ross Prentice;Marian L Neuhouser;Helen Truby - 通讯作者:
Helen Truby
Energy intake is associated with dietary macronutrient densities: inversely with protein and monounsaturated fat and positively with polyunsaturated fat and carbohydrate among postmenopausal females
在绝经后女性中,能量摄入与膳食常量营养素密度相关:与蛋白质和单不饱和脂肪呈负相关,与多不饱和脂肪和碳水化合物呈正相关
- DOI:
10.1016/j.ajcnut.2025.03.011 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:6.900
- 作者:
Ross L Prentice;Aaron K Aragaki;Cheng Zheng;JoAnn E Manson;Lesley F Tinker;Dale A Schoeller;Michele N Ravelli;Daniel Raftery;GA Nagana Gowda;Sandi L Navarro;Ying Huang;Yasmin Mossavar-Rahmani;Robert B Wallace;Karen C Johnson;Johanna W Lampe;Marian L Neuhouser - 通讯作者:
Marian L Neuhouser
Marian L Neuhouser的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Marian L Neuhouser', 18)}}的其他基金
Physiological changes underlying the weight loss plateau in humans
人类减肥平台期的生理变化
- 批准号:
10734323 - 财政年份:2023
- 资助金额:
$ 59.53万 - 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
- 批准号:
10191413 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
- 批准号:
10407996 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
- 批准号:
10596229 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
8798420 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
8932683 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
9102198 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
9314567 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Interaction of Vitamin D & Vitamin A with Lung Cancer Risk in Non-Smoking Females
维生素 D 的相互作用
- 批准号:
8601154 - 财政年份:2013
- 资助金额:
$ 59.53万 - 项目类别:
Interaction of Vitamin D & Vitamin A with Lung Cancer Risk in Non-Smoking Females
维生素 D 的相互作用
- 批准号:
8443600 - 财政年份:2013
- 资助金额:
$ 59.53万 - 项目类别:
相似海外基金
A database construction of asbestos world flow for supply chain analysis: a multi-regional input-output approach
用于供应链分析的石棉世界流量数据库构建:多区域投入产出方法
- 批准号:
22K05940 - 财政年份:2022
- 资助金额:
$ 59.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Comprehensive study on institutional design for Establishment of New Asbestos Health Damage Relief System
建立新型石棉健康损害救助体系的制度设计综合研究
- 批准号:
21K12369 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on asbestos release from weathered asbestos slate roofing materials during rainfall
降雨期间风化石棉板岩屋顶材料石棉释放的研究
- 批准号:
21K04331 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of in silico model for health impact assessment of Asbestos emitted from building materials
开发用于建筑材料排放石棉健康影响评估的计算机模型
- 批准号:
20KK0099 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
ALERT Real-Time Airborne Asbestos Detection
ALERT 实时机载石棉检测
- 批准号:
72508 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Feasibility Studies
Integrated automated asbestos fibre-counting and digital certification technology
集成自动化石棉纤维计数和数字认证技术
- 批准号:
105739 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Study
Integrated automated asbestos fibre-counting and digital certification technology
集成自动化石棉纤维计数和数字认证技术
- 批准号:
73834 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Feasibility Studies
ACME: Asbestos Containing Materials evaluation
ACME:含石棉材料评估
- 批准号:
85072 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Collaborative R&D
The National Centre for Asbestos Related Diseases (NCARD)
国家石棉相关疾病中心 (NCARD)
- 批准号:
nhmrc : 1197652 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Centres of Research Excellence
Public policy research on asbestos disaster prevention centered on risk management
以风险管理为核心的石棉防灾公共政策研究
- 批准号:
20H04393 - 财政年份:2020
- 资助金额:
$ 59.53万 - 项目类别:
Grant-in-Aid for Scientific Research (B)