Infrastructure Support and Pilot Tissue Collection for the CARET Biorepository
CARET 生物样本库的基础设施支持和试点组织采集
基本信息
- 批准号:10374863
- 负责人:
- 金额:$ 59.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:All-Trans-RetinolAsbestosAwardBeta CaroteneBiocompatible MaterialsBiologicalBiological MarkersBiological Specimen BanksBiological Specimen databaseBiopsyCaliforniaCancer Prevention TrialCardiovascular DiseasesCaroteneCause of DeathCessation of lifeCharacteristicsCigarette SmokerClinicalClinical DataCollectionColon CarcinomaConnecticutConsentDNADataDatabasesDevelopmentDiagnosisDiagnosticDiagnostic Neoplasm StagingDiseaseEarly DiagnosisEndpoint DeterminationEnrollmentEtiologyExposure toFundingFunding MechanismsGoalsGovernmentGrantHuman ResourcesIncidenceInfrastructureInterventionIntervention TrialInvestigationLaboratoriesLife StyleMaintenanceMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of prostateMalignant neoplasm of urinary bladderMedical RecordsMicronutrientsMineralsMolecular EpidemiologyOccupational ExposureOperative Surgical ProceduresParentsParticipantPeer ReviewPersonsPhasePlasmaPopulationPopulations at RiskPositioning AttributePreventionProceduresPrognosisPublicationsPublishingRandomizedRecordsResearchResearch PersonnelResectedResourcesSafetySamplingScheduleSerumSiteSmoking HistorySpecimenStage at DiagnosisStructure of parenchyma of lungTimeTissue BanksTissue SampleTissuesTobaccoTumor TissueTwin Multiple BirthUnited States National Institutes of HealthUpdateVitaminsWashingtonWhole BloodWomanbiobankcancer diagnosiscancer epidemiologycancer preventioncigarette smokingcohortcostdata sharingdietarydouble-blind placebo controlled trialearly detection biomarkerseditorialefficacy trialfollow-upgenetic analysisgenetic epidemiologyhigh riskhigh risk populationimprovedindexingintervention effectmalignant breast neoplasmmenmolecular subtypesmortalityneoplasm registrynutritionnutritional epidemiologypersonalized medicinepost interventionpublic databaserecruitrepositoryresearch and developmentretinyl palmitatetobacco abusetooltumortumor heterogeneityweb site
项目摘要
Project Summary
The Carotene and Retinol Efficacy Trial (CARET) was a randomized, double-blind, placebo-controlled trial of
the cancer prevention efficacy and safety of a daily combination of 30 mg of β-carotene and 25,000 IU of
retinyl palmitate in 18,314 persons at high risk for lung cancer. The trial began recruitment in 1985 and was
halted in January 1996, 21 months ahead of schedule, with the twin conclusions of no benefit and substantial
evidence of a harmful effect of the intervention on both lung cancer incidence and total mortality. Participants
continued to be followed for over nine years post-intervention, with updated lung cancer incidence and
cardiovascular disease mortality findings published in 2004. On June 30, 2005, CARET stopped active follow-
up of participants. During the active intervention phase of CARET, serum, plasma, whole blood (for DNA), and
lung tissue specimens were collected. These biospecimens make up the CARET biorepository, which is the
focus of this application. The CARET biorepository is a key tool in studying disease development and
progression. It is an invaluable legacy of the parent trial with specimens available to any investigator with a
hypothesis-driven project.
The specific aims of the current grant cycle (2013-2018) included extending the database and online
accessibility to include participant use of micronutrient, mineral, and vitamin supplements; baseline laboratory
values; and stage at diagnosis of lung, prostate, colon, and breast cancer cases. We also extended CARET
follow-up of cancer diagnoses, deaths, and causes of death through 2012/13 via linkages to the National Death
Index, Cancer Registry of Connecticut, and the Cancer Registries of California and Washington. This has
greatly increased the total numbers of identified incident cancer cases (n=6,773) as well as extending the
follow-up of the entire cohort (median follow-up to first diagnosis is 18 years and to death is 20 years). In our
goal to make the CARET biorepository accessible, during the current grant cycle (2013 – 2018), biospecimens
and /or data have been provided to investigators, which have resulted in 23 peer-reviewed publications.
Currently there are 93 ongoing projects utilizing CARET biospecimens.
In this application, we request funds to continue support of the CARET biorepository and the associated
extensive database. We also propose to pilot procedures to obtain updated signed releases of medical records
and consent for the utilization of biologic material in the CARET biorepositories consistent with recent
developments on obtaining consent for broad research purposes and data sharing. In addition, to position
CARET for studies examining the association of tumor heterogeneity and molecular subtypes with etiologic
factors and survival, we propose to conduct a pilot to obtain diagnostic lung cancer biopsy/surgical specimens
from Washington State CARET participants diagnosed after 2003. This will include obtaining updated release
of medical records and consent for broad research purposes and data sharing.
项目摘要
胡萝卜素和视黄醇疗效试验(CARET)是一项随机、双盲、安慰剂对照试验,
每日30 mg β-胡萝卜素和25,000 IU
棕榈酸视黄酯在18,314名肺癌高危人群中的应用该试验于1985年开始招募,
1996年1月停止,比计划提前21个月,得出两个结论:没有好处,
有证据表明,干预措施对肺癌发病率和总死亡率都有有害影响。参与者
干预后继续随访9年以上,更新肺癌发病率,
2004年发表的心血管疾病死亡率调查结果。2005年6月30日,CARET停止积极跟进-
的参与者。在CARET的主动干预阶段,血清、血浆、全血(用于DNA)和
收集肺组织标本。这些生物标本组成了CARET生物储存库,
这个应用程序的重点。CARET生物储存库是研究疾病发展的关键工具,
进展这是母试验的宝贵遗产,任何研究者都可以获得样本,
假设驱动项目。
当前赠款周期(2013-2018年)的具体目标包括扩大数据库和在线
可获得性包括参与者使用微量营养素、矿物质和维生素补充剂;基线实验室
值;以及肺癌、前列腺癌、结肠癌和乳腺癌病例诊断时的分期。我们还扩展了CARET
2012/13年度,通过与国家死亡率监测中心的联系,对癌症诊断、死亡和死亡原因进行跟踪
索引,康涅狄格州癌症登记处,以及加州和华盛顿癌症登记处。这
大大增加了确定的癌症病例总数(n= 6,773),并扩大了
整个队列的随访(首次诊断的中位随访时间为18年,死亡为20年)。在我们
目标是在当前的赠款周期(2013 - 2018年)内,使CARET生物储存库能够获得生物标本,
和/或数据已提供给研究人员,这导致了23个同行评审的出版物。
目前有93个正在进行的项目利用CARET生物标本。
在这项申请中,我们要求资金继续支持CARET生物储存库和相关的
广泛的数据库。我们亦建议试行有关程序,以取得经签署的最新医疗纪录
并同意在CARET生物储存库中使用生物材料,
为广泛的研究目的和数据共享获得同意方面的进展。此外,为了定位
CARET用于检查肿瘤异质性和分子亚型与病因学之间关系的研究
因素和生存率,我们建议进行试点,以获得诊断肺癌活检/手术标本
来自2003年后确诊的华盛顿州CARET参与者。这将包括获得更新的版本
医疗记录和同意广泛的研究目的和数据共享。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marian L Neuhouser其他文献
Investigating the impact of body composition on the estimation of resting metabolic rate: new equations for adults aged ≥65 years developed using cross-sectional data
探究身体成分对静息代谢率估算的影响:利用横断面数据推导出适用于65岁及以上成年人的新公式
- DOI:
10.1016/j.ajcnut.2024.12.023 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:6.900
- 作者:
Judi Porter;Leigh C Ward;Kay Nguo;Zoe Davidson;Simone Gibson;Ross Prentice;Marian L Neuhouser;Helen Truby - 通讯作者:
Helen Truby
Energy intake is associated with dietary macronutrient densities: inversely with protein and monounsaturated fat and positively with polyunsaturated fat and carbohydrate among postmenopausal females
在绝经后女性中,能量摄入与膳食常量营养素密度相关:与蛋白质和单不饱和脂肪呈负相关,与多不饱和脂肪和碳水化合物呈正相关
- DOI:
10.1016/j.ajcnut.2025.03.011 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:6.900
- 作者:
Ross L Prentice;Aaron K Aragaki;Cheng Zheng;JoAnn E Manson;Lesley F Tinker;Dale A Schoeller;Michele N Ravelli;Daniel Raftery;GA Nagana Gowda;Sandi L Navarro;Ying Huang;Yasmin Mossavar-Rahmani;Robert B Wallace;Karen C Johnson;Johanna W Lampe;Marian L Neuhouser - 通讯作者:
Marian L Neuhouser
Marian L Neuhouser的其他文献
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{{ truncateString('Marian L Neuhouser', 18)}}的其他基金
Physiological changes underlying the weight loss plateau in humans
人类减肥平台期的生理变化
- 批准号:
10734323 - 财政年份:2023
- 资助金额:
$ 59.53万 - 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
- 批准号:
10191413 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
- 批准号:
10407996 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
- 批准号:
10596229 - 财政年份:2021
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
8798420 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
8932683 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
9102198 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
- 批准号:
9314567 - 财政年份:2014
- 资助金额:
$ 59.53万 - 项目类别:
Interaction of Vitamin D & Vitamin A with Lung Cancer Risk in Non-Smoking Females
维生素 D 的相互作用
- 批准号:
8601154 - 财政年份:2013
- 资助金额:
$ 59.53万 - 项目类别:
Interaction of Vitamin D & Vitamin A with Lung Cancer Risk in Non-Smoking Females
维生素 D 的相互作用
- 批准号:
8443600 - 财政年份:2013
- 资助金额:
$ 59.53万 - 项目类别:
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