RELATIONSHIP OF BREAST CANCER SUBTYPE, RISK FACTORS AND ANCESTRY IN HISPANIC A...

摘要：本项目针对我们的人口健康和健康差距中心(CPHHD) 应用程序的首要主题是了解和预防乳腺癌前兆、发病率和 旨在更好地了解这些地区乳腺癌的潜在生物学特征 女人。乳腺癌存活率的差异甚至在种族和民族之间也有很好的记录 社会和经济原因。不同群体之间的肿瘤生物学差异也可能是导致 乳腺癌预后的差异。最近乳腺癌的基因表达谱加深了我们的 对这种非常不同的疾病的理解，并导致了一种新的亚型特异性疾病的发展范式 治疗和预防策略。然而，乳腺癌的基因表达亚型是 完全基于对非西班牙裔白人女性的研究产生的数据。由于缺乏资源而造成的差距 少数族裔妇女的生物数据将继续阻碍新的预防方法的实施 在这些不同的人群中进行治疗。随着针对特定亚型的新疗法的出现 同样重要的是，拉美裔妇女的表情数据也可以用来确定两者之间的联系 并评估在对非西班牙裔妇女的研究中产生的数据的相关性。 为了更好地了解拉美裔女性乳腺癌的生物学亚型及其与 遗传学和环境影响(风险因素)对特定乳腺肿瘤亚型的发展，我们 将对615名拉美裔妇女进行一项研究，主要基于项目3中概述的乳腺癌病例。 我们的主要目标是： 1.确定患有乳房的西班牙裔妇女肿瘤亚型与血统的关系 癌症。这将通过以下方式实现： A)通过基因表达阵列确定肿瘤亚型 B)通过祖先信息确定祖先--五个标记(AIMS) C)将肿瘤亚型与AIMS定义的个体祖先进行比较。 我们的次要目标是 2.探讨拉美裔乳房肿瘤亚型与已有危险因素的关系 女人。 3.拉美裔肿瘤中肿瘤相关通路相关基因的表达 妇女以及这些途径与血统和风险因素的关系。

Abstract: This project addresses our Center for Populafion Health and Health Disparities (CPHHD) application's overarching theme of understanding and preventing breast cancer precursors, morbidity, and mortality among Latinas by aiming to better understand the underlying biology of breast cancer in these women. Disparities in breast cancer survival befi^'een racial and ethnic groups have some well-documented social and economic causes. It is possible that differences in tumor biology between groups also contribute to differences in breast cancer outcomes. Recent gene expression profiling of breast cancer has deepened our understanding of this very heterogeneous disease and led to a new paradigm for the development of subtypespecific therapies and prevenfion strategies. However, the gene expression subtyping of breast cancer is based entirely on data generated by studies of non-Hispanic white women. The disparity created by the lack of biological data In minority women will continue to impede the implementafion of new approaches to prevention and treatment in these diverse populafions. As new treatments directed at specific subtypes become available it is essential that expression data from Hispanic women is also available¿both to identify associations specific to Hispanic women and to assess the relevance of data generated in studies of non-Hispanic women. To better understand the biological subtypes of breast cancer in Hispanic women and the relationship of genetics and environmental influences (risk factors) to the development of specific breast tumor subtypes, we will conduct a study of 615 Hispanic women based primarily on the breast cancer cases outlined in Project 3. Our primary aim is to: 1. Determine the relationship between tumor subtype and ancestry in Hispanic women with breast cancer. This will be accomplished by: a) determining the tumor subtype by gene expression array b) determining ancestry through ancestry informafive markers (AIMs) c) comparing tumor subtype with individual ancestry as defined through the AIMs. Our secondary aims are to 2. Explore the relationship between established risk factors and breast tumor subtypes in Hispanic women. 3. Explore expression of genes involved in tumor-associated pathways in the tumors of Hispanic women and the relationship of these pathways with ancestry and risk factors.