Using multiple datasets to examine youth psychiatric diagnosis

使用多个数据集检查青少年精神病学诊断

• 批准号: 8268457
• 负责人: Prudence Winslow Fisher
• 金额: $ 65.31万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268457
• 关键词: 10 year old; Address; Adjustment Disorders; Adolescent; Adolescent Psychiatry; Adopted; Adult; Advisory Committees; Affect; Age; Age of Onset; Algorithms; American Psychiatric Association; Antisocial Personality Disorder; Anxiety; Anxiety Disorders; Archives; Attention deficit hyperactivity disorder; Behavior; Categories; Characteristics; Child; Child Psychiatry; Childhood; Classification; Clinical; Communities; Comorbidity; Conduct Disorder; Consensus; DSM-III; DSM-IV; DSM-V; Data; Data Aggregation; Data Set; Databases; Depressed mood; Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Diagnostic and Statistical Manual of Mental Disorders; Differential Diagnosis; Dimensions; Disease; Disruptive Behavior Disorder; Dysthymic Disorder; Excision; Feeling suicidal; Frequencies; Fright; Future; Generalized Anxiety Disorder; Goals; Health Occupations; Health Professional; Impairment; Individual; International; Interview; Investigation; Knowledge; Life; Link; Literature; Major Depressive Disorder; Manuals; Measures; Mental Depression; Mental Health; Mental disorders; Methodology; Modeling; Modification; Mood Disorders; Moods; National Institute of Mental Health; Natural History; Oppositional Defiant Disorder; Outcome; Panic Disorder; Pattern; Phobic anxiety disorder; Prevalence; Probability Samples; Procedures; Psychiatric Diagnosis; Psychiatrist; Psychologist; Psychometrics; Psychopathology; Qualifier; Research; Research Personnel; Resources; Role; Sampling; Schedule; Severities; Social Functioning; Source; Specific qualifier value; Structure; Symptoms; System; Taxon; Testing; Time; United States National Institutes of Health; Variant; Work; Youth; age related; base; care systems; child well being; comparative; comparison group; cost; depressive symptoms; disease classification; disorder subtype; early onset; experience; follow-up; improved; instrument; longitudinal course; meetings; minor depressive disorder; named group; novel strategies; outcome forecast; prospective; response; stressor; symposium; young adult

Since the development of DSM-III in 1980, and through its subsequent revisions (DSM-III-R, DSM-IV), DSM criteria have become almost universally accepted as a basis for diagnosis in the mental health professions. Despite this broad acceptance, there is a paucity of empirical data available that support the highly specified diagnostic formations embodied in manual. The impact that adding, removing, or otherwise altering criteria may have on disorder prevalence, natural history, or associated impairment has not been well studied. There is little consensus on the issue of comorbidity and the extent to which this phenomenon represents misplaced diagnostic boundaries, responses to common antecedents, or causal linkages between disorders. Finally, and especially important to child psychiatry, there is relatively little information available about developmental differences in the expression and significance of DSM-defined disorders. The proposed project would compile and analyze a database of diagnostic and symptom data collected by 16 investigations of youth, all of which used a DSM- linked version of the DISC. The total database would have data on approximately 19,000 children and adolescents -- longitudinal data is available on approximately 14,000 of these. In addition to the specific analytic aims outlined in the proposal (examining the validity of diagnostic subtypes and specifiers; understanding diagnostic boundaries and comorbidity; justifying diagnostic thresholds; studying the appropriateness of individual symptom criteria; comparing dimensional and categorical definitions), the investigators will work closely with the DSM-V Task Force and others in order to identify and address the most important and pressing diagnostic and classification issues facing the field. While the immediate practical benefit of this project will be to inform the development of DSM-V, its longer-term importance will be to address the epistemological underpinnings of child and adolescent psychiatric nosology in general. In a cost-efficient, manner this project will afford a unique opportunity to address many questions that can only be answered with such a large aggregated dataset with well-defined samples assessed with a standardized, comprehensive and transparent methodology. The aggregated data will also represent an invaluable data resource for future research.

自1980年DSM-III发展以来，并通过其随后的修订 （DSM-III-R，DSM-IV），DSM标准几乎已被普遍接受为基础 用于心理健康专业的诊断。尽管接受了这种广泛的接受，但仍有一个 可用的经验数据的匮乏，支持高度指定的诊断形成 体现手动。增加，删除或以其他方式更改标准的影响 可能患有疾病患病率，自然病史或相关障碍尚未 经过深入研究。关于合并症的问题几乎没有达成共识和 这种现象代表了放错位置的诊断边界，对 常见的先例或疾病之间的因果关系。最后，尤其是 对儿童精神病学很重要，有关的信息相对较少 DSM定义疾病的表达和意义上的发展差异。 拟议的项目将编译和分析诊断数据库和 16个对青年的研究收集的症状数据，所有这些都使用了DSM- 光盘的链接版本。总数据库将大约具有数据 19,000名儿童和青少年 - 纵向数据大约可用 其中14,000。 除了提案中概述的具体分析目的（检查的有效性） 诊断子类型和指定符；了解诊断边界和 合并症；为诊断阈值辩护；研究个人的适当性 症状标准；比较尺寸和分类定义），调查人员 将与DSM-V特遣部队和其他工作组紧密合作，以识别和解决 该领域面临的最重要，最紧迫的诊断和分类问题。 尽管该项目的直接实际利益将是为了告知 DSM-V，其长期重要性将是解决认识论基础 一般来说，儿童和青少年的精神病学。以经济高效的方式 项目将提供一个独特的机会来解决许多只能是 通过如此大的汇总数据集回答，并评估了定义明确的样本 一种标准化，全面和透明的方法。汇总数据将 还代表了未来研究的宝贵数据资源。