Using multiple datasets to examine youth psychiatric diagnosis

使用多个数据集检查青少年精神病学诊断

• 批准号: 8268457
• 负责人: Prudence Winslow Fisher
• 金额: $ 65.31万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268457
• 关键词: 10 year old; Address; Adjustment Disorders; Adolescent; Adolescent Psychiatry; Adopted; Adult; Advisory Committees; Affect; Age; Age of Onset; Algorithms; American Psychiatric Association; Antisocial Personality Disorder; Anxiety; Anxiety Disorders; Archives; Attention deficit hyperactivity disorder; Behavior; Categories; Characteristics; Child; Child Psychiatry; Childhood; Classification; Clinical; Communities; Comorbidity; Conduct Disorder; Consensus; DSM-III; DSM-IV; DSM-V; Data; Data Aggregation; Data Set; Databases; Depressed mood; Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Diagnostic and Statistical Manual of Mental Disorders; Differential Diagnosis; Dimensions; Disease; Disruptive Behavior Disorder; Dysthymic Disorder; Excision; Feeling suicidal; Frequencies; Fright; Future; Generalized Anxiety Disorder; Goals; Health Occupations; Health Professional; Impairment; Individual; International; Interview; Investigation; Knowledge; Life; Link; Literature; Major Depressive Disorder; Manuals; Measures; Mental Depression; Mental Health; Mental disorders; Methodology; Modeling; Modification; Mood Disorders; Moods; National Institute of Mental Health; Natural History; Oppositional Defiant Disorder; Outcome; Panic Disorder; Pattern; Phobic anxiety disorder; Prevalence; Probability Samples; Procedures; Psychiatric Diagnosis; Psychiatrist; Psychologist; Psychometrics; Psychopathology; Qualifier; Research; Research Personnel; Resources; Role; Sampling; Schedule; Severities; Social Functioning; Source; Specific qualifier value; Structure; Symptoms; System; Taxon; Testing; Time; United States National Institutes of Health; Variant; Work; Youth; age related; base; care systems; child well being; comparative; comparison group; cost; depressive symptoms; disease classification; disorder subtype; early onset; experience; follow-up; improved; instrument; longitudinal course; meetings; minor depressive disorder; named group; novel strategies; outcome forecast; prospective; response; stressor; symposium; young adult

Since the development of DSM-III in 1980, and through its subsequent revisions (DSM-III-R, DSM-IV), DSM criteria have become almost universally accepted as a basis for diagnosis in the mental health professions. Despite this broad acceptance, there is a paucity of empirical data available that support the highly specified diagnostic formations embodied in manual. The impact that adding, removing, or otherwise altering criteria may have on disorder prevalence, natural history, or associated impairment has not been well studied. There is little consensus on the issue of comorbidity and the extent to which this phenomenon represents misplaced diagnostic boundaries, responses to common antecedents, or causal linkages between disorders. Finally, and especially important to child psychiatry, there is relatively little information available about developmental differences in the expression and significance of DSM-defined disorders. The proposed project would compile and analyze a database of diagnostic and symptom data collected by 16 investigations of youth, all of which used a DSM- linked version of the DISC. The total database would have data on approximately 19,000 children and adolescents -- longitudinal data is available on approximately 14,000 of these. In addition to the specific analytic aims outlined in the proposal (examining the validity of diagnostic subtypes and specifiers; understanding diagnostic boundaries and comorbidity; justifying diagnostic thresholds; studying the appropriateness of individual symptom criteria; comparing dimensional and categorical definitions), the investigators will work closely with the DSM-V Task Force and others in order to identify and address the most important and pressing diagnostic and classification issues facing the field. While the immediate practical benefit of this project will be to inform the development of DSM-V, its longer-term importance will be to address the epistemological underpinnings of child and adolescent psychiatric nosology in general. In a cost-efficient, manner this project will afford a unique opportunity to address many questions that can only be answered with such a large aggregated dataset with well-defined samples assessed with a standardized, comprehensive and transparent methodology. The aggregated data will also represent an invaluable data resource for future research.

自1980年制定DSM-III以来，并通过其后续修订 （DSM-III-R、DSM-IV），DSM 标准已几乎被普遍接受作为基础 用于心理健康专业的诊断。尽管得到了广泛的接受，但仍有一个 缺乏支持高度具体的诊断形式的经验数据 体现在手册中。添加、删除或以其他方式更改标准的影响 可能与疾病患病率、自然史或相关损伤有关 得到了很好的研究。对于合并症问题及其程度尚无共识 这种现象代表了错误的诊断边界，对 共同的前因，或疾病之间的因果关系。最后，特别是 对于儿童精神病学来说很重要，但关于这方面的信息相对较少 DSM 定义的疾病的表达和意义的发育差异。 拟议的项目将编译和分析诊断和 16 项青少年调查收集的症状数据，所有调查均使用 DSM- DISC 的链接版本。整个数据库的数据大约为 19,000 名儿童和青少年——可获得大约大约 其中 14,000 个。 除了提案中概述的具体分析目标（检查 诊断亚型和说明符；了解诊断界限和 合并症；证明诊断阈值的合理性；研究个人的适当性 症状标准；比较维度和分类定义），研究人员 将与 DSM-V 工作组和其他机构密切合作，以确定并解决 该领域面临的最重要和最紧迫的诊断和分类问题。 虽然该项目的直接实际好处将是为以下领域的发展提供信息 DSM-V，其长期重要性将是解决认识论基础 儿童和青少年精神病学的一般分类学。以一种具有成本效益的方式， 项目将提供一个独特的机会来解决许多只能通过 回答了如此大的聚合数据集和明确定义的样本评估 标准化、全面且透明的方法。汇总的数据将 也为未来的研究提供了宝贵的数据资源。