Pilot Project

试点项目

• 批准号: 8329664
• 负责人: Kelly Brittain
• 金额: $ 3.31万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8329664
• 关键词: Address; Adult; Advisory Committees; Affect; African American; Attitude; Belief; Biological; Blood; Cancer Center; Characteristics; Cities; Clinical Research; Clinics and Hospitals; Collection; Communities; Community Networks; Data; Development; Disease; Educational Intervention; Elderly; Feedback; Feeling; Focus Groups; Genomics; Hair; Health; Health Status; Institutes; Institution; Knowledge; Learning; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical; Medicine; Michigan; Minority; National Cancer Institute; Outcome; Perception; Pilot Projects; Policies; Populations at Risk; Process; Qualitative Research; Questionnaires; Research; Respondent; Sampling; Surveys; Swab; Systems Analysis; Testing; Tissue Sample; Tissues; Tumor Pathology; Umbilical Cord Blood; Urine; Voice; anticancer research; base; biobank; cancer genetics; expectation; improved; malignant breast neoplasm; medical schools; medically underserved; member; prognostic; programs; tumor; willingness

Pilot Project Summary. We propose to investigate how the cultural beliefs, perceptions, and feelings of older, underserved urban African American adults about the process of collecting biospecimens for research affects their willingness to donate biospecimens for clinical studies. Almost no careful, systematic and in-depth studies have been conducted in Detroit to determine how minority elder residents feel about donating biological samples to the medical institutions in this city (and beyond) for extensive testing and development of personalized medicine and advanced genomic research. The National Cancer Institute, Karmanos Cancer Institute (KCI), WSU School of Medicine, Josephine Ford Cancer Center (JFCC) and affiliated hospitals/clinics are increasing the number of biobanking initiatives (e.g., cord blood, blood and buccal swabs for lung cancer genetic studies, tissue samples for prostate cancer, disease tumor samples for prognostic breast cancer studies, commercial ventures, etc.). However, this increase makes it morally and ethically imperative to ascertain how members ofthe most vulnerable and at-risk populations in our region feel about these research efforts. Their feelings, perceptions, expectations and concerns can and will affect biospecimen collection and banking. This research pilot is timely for conducting research in the medically underserved urban southeast Michigan region. For a biospecimen collection, processing, banking and analysis system to be effective, our stakeholders and community residents must be continually engaged early and often, to rightfully and voluntarily discuss their views, voice their concerns and expectations and articulate in a collaborative context the policies for implementation. To reach our community and begin this collaborative dialogue, we plan a systematic set of CBPR pilot activities with our Southeast Michigan CNP II Community Advisory Group (CAG) representatives. First we will conduct a qualitative research component. Our CAG members will assist us in planning and conducting focus groups to elicit, listen and learn from diverse community members. CAG members will provide feedback on interpretation of these focus group findings and together we will develop a survey questionnaire to assess how demographic, health, and attitudinal factors of older, underserved African American adults are associated with decisions to donate biospecimens. We will address the most frequently collected samples in cancer research: tumor pathology tissue, blood, buccal swabs, urine, and hair. Finally, based on the focus group and survey findings, we will, togetherwith our Research Advisory Committee (RAC; see Section N3/0utreach Program) develop and evaluate a pilot educational intervention to assist older adults in understanding how biospecimen collection and banking can contribute to the reduction of disparities in health outcomes.

试点项目摘要。 我们建议调查如何的文化信仰，观念和感受的老年人，服务不足的城市非洲裔美国成年人的过程中收集生物标本的研究影响他们的意愿捐赠生物标本的临床研究。在底特律，几乎没有进行过仔细、系统和深入的研究，以确定少数族裔老年居民对向该市（及其他地区）的医疗机构捐赠生物样本的感受，以进行广泛的测试和开发个性化医疗和先进的基因组研究。国家癌症研究所，Karmanos Cancer 研究所（KCI）、华盛顿州立大学医学院、约瑟芬福特癌症中心（JFCC）和附属医院/诊所正在增加生物库计划的数量（例如，脐带血、用于肺癌遗传研究的血液和口腔拭子、用于前列腺癌的组织样品、用于乳腺癌预后研究的疾病肿瘤样品、商业风险等）。然而，这种增加使得在道义上和伦理上必须确定我们区域最脆弱和最危险的人口成员对这些问题的看法。 研究工作。他们的感受、看法、期望和关切能够并将影响生物标本的收集和储存。这项研究试点是及时进行研究，在医疗服务不足的城市密歇根州东南部地区。为了使生物标本采集、处理、储存和分析系统有效，我们的利益相关者和社区居民必须尽早和经常地参与进来，以正确和自愿的方式讨论他们的观点，表达他们的担忧和期望，并在合作中表达意见。 落实政策的背景。 为了接触我们的社区并开始这种合作对话，我们计划与我们的东南密歇根州CNP II社区咨询小组（CAG）代表进行一系列系统的CBPR试点活动。首先，我们将进行定性研究。我们的CAG成员将协助我们规划和进行焦点小组，以吸引，倾听和学习不同的社区成员。CAG成员将提供以下反馈： 这些焦点小组的调查结果的解释，我们将共同制定一份调查问卷，以评估人口，健康和态度因素的老年人，服务不足的非洲裔美国人与决定捐赠生物标本。我们将讨论癌症研究中最常收集的样本： 肿瘤病理组织、血液、口腔拭子、尿液和毛发。最后，根据焦点小组和调查结果，我们将与我们的研究咨询委员会（RAC;见第N3/0节超接触计划）一起制定和评估一项试点教育干预措施，以帮助老年人了解生物标本如何 收集和储存有助于减少保健成果方面的差距。