Promoting Teen Health: A Web-based Intervention to Prevent Risky Driving

描述（由申请人提供）：这份K99-R00申请表为候选人凯瑟琳·麦克唐纳博士准备了一个研究密集型的职业，开发和测试针对青少年健康威胁的基于网络的干预措施。这项研究计划的第一步将集中在青少年死亡和残疾的主要原因：机动车碰撞。K99的总体目标是在注意力和青少年发展、驱动结果测量、干预开发和随机对照试验（RCT）方法方面获得先进的研究培训，以开发和完善基于网络的干预措施，促进新手青少年安全驾驶行为和降低驾驶风险。R00的总体目标是实施K99开发的基于网络干预的高级版本的I期随机对照试验可行性研究。K99的具体目标是：1)接受注意力和青少年发展理论方面的高级培训；行为干预的创造和测试；RCT方法学和先进的统计方法；结果测量（眼动仪、驾驶模拟器、自述测量和驾驶记录）；职业发展;负责任的研究行为；2)通过对青少年进行焦点小组调查，得出基于理论驱动的网络干预措施的发展内容，以促进安全驾驶行为和降低驾驶风险；3)对基于网络的危险驾驶干预原型进行初步测试和完善（包括招募、筛选、入组、基线评估和干预交付），这将作为R00一期RCT可行性研究的基础；4)利用初步测试和改进过程中收集的数据，完善主要结果（注意力保持）和次要结果（自我报告的危险驾驶行为、驾驶表现、驾驶引证和碰撞报告）的指标。K99研究培训将由两名在危险驾驶、伤害预防和随机对照试验方面具有丰富经验的资深科学家指导。R00的具体目的是评估K99开发的基于网络的危险驾驶干预的高级版本的可行性，其中青少年驾驶员在过去90天内获得执照。我们将：1)基于K99的数据开发基于网络的风险驾驶干预的高级版本；2)实施基于网络的危险驾驶干预I期RCT评估：a)招募并随机分配青少年到基于网络的危险驾驶干预组或对照组（对照组将接受基于网络的健康饮食干预）；b)干预组依从性测量；和c)。干预组和对照组的保留率。作为R00的次要目的，我们将在第1个月和第3个月评估基于网络的危险驾驶干预对注意维持的主要结果和自我报告的危险驾驶行为的次要结果以及驾驶绩效的效应大小；在6个月时，关于自我报告的危险驾驶行为驾驶传票和撞车事故的次要结果。R00 I期RCT可行性研究的结果将作为R01 II期疗效试验的初步数据。

DESCRIPTION (provided by applicant): This K99-R00 application prepares the candidate, Catherine McDonald, PhD, for a research-intensive career developing and testing web-based interventions directed toward threats to teen health. The first step in this program of research will focus on the leading cause of death and disability for teens: motor vehicle crashes. The overall goal of the K99 is to gain advanced research training in attention and adolescent development, driving outcome measures, intervention development, and randomized controlled trials (RCT) methodology in order to develop and refine a web-based intervention that promotes safe driving behaviors and driving risk reduction in novice teen drivers. The overall goal of the R00 is to implement a Phase I RCT feasibility study of an advanced version of the K99 developed web-based intervention. The specific aims of the K99 are: 1) To receive advanced training in: attention and adolescent developmental theory; creation and testing of behavioral interventions; RCT methodology and advanced statistical methods; outcome measures (eye tracking device, driving simulator, self-report measures and driving records); career development; and responsible conduct of research; 2) To derive content for the development of a theoretically-driven, web-based intervention to promote safe driving behaviors and driving risk reduction using focus groups with teens; 3) To conduct preliminary testing and refinement of a prototype web-based risky driving intervention (including recruitment, screening, enrollment, baseline assessment, and intervention delivery), that will serve as the foundation for the R00 Phase I RCT feasibility study; and 4) To refine the metrics for the primary outcome (attention maintenance), and secondary outcomes (self-reported risky driving behaviors, driving performance, and driving citations and crash reports) using data collected during the preliminary testing and refinement. The K99 research training will be under the guidance of two senior scientists with extensive experience in risky driving, injury prevention, and RCTs. The specific aim of the R00 is to assess the feasibility of an advanced version of the web-based risky driving intervention developed in the K99, with teen drivers licensed in the previous 90 days. We will: 1) Develop an advanced version of web-based risky driving intervention based on data from the K99; 2) Implement a Phase I RCT of the web based risky driving intervention to assess: a) Recruit and randomization of teens to web-based risky driving intervention or control group (the control group will receive a web-based intervention for healthy eating); b) Measurement of adherence among the intervention group; and c). Retention in the intervention and control groups. As a secondary aim of the R00, we will estimate effect size of the web- based risky driving intervention at 1 and 3 months on the primary outcome of attention maintenance and the secondary outcomes of self-reported risky driving behaviors, and driving performance; and at 6 months on the secondary outcomes of self-reported risky driving behaviors and driving citations and crashes. Results of the R00 Phase I RCT feasibility study will be used as preliminary data for an R01 Phase II efficacy trial. PUBLIC HEALTH RELEVANCE: Motor vehicle crashes are the leading cause of death for teenagers. A large proportion of crashes result from teen drivers taking their eyes off the road to perform other activities in the vehicle. This application supports the training of a promising young scientist by experienced mentors to develop and test a web-based intervention to improve attention maintenance in novice teen drivers, thereby reducing the risk of crashes and the associated injuries and deaths.