Driving after Concussion: Examination of the Adolescent Brain and Behaviors

脑震荡后驾驶：青少年大脑和行为的检查

• 批准号: 10552399
• 负责人: Catherine Claire McDonald
• 金额: $ 6.23万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-03 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10552399
• 关键词: Address; Administrative Supplement; Adolescence; Adolescent; Adult; Automobile Driving; Behavior; Brain Concussion; Categories; Childhood; Chronic; Complex; Data Analyses; Data Collection; Diagnosis; Disease; Ecological momentary assessment; Evaluation; Fellowship; Foundations; Freedom; Funding; Habits; Heart Diseases; Heart Research; Heart failure; Information Dissemination; Institution; Interview; Lead; Learning; Licensing; Licensure; Literature; Medical; Mentors; Morbidity - disease rate; Motor Vehicles; Neurocognitive; Parents; Perception; Personal Satisfaction; Persons; Physiological; Population; Reporting; Research; Research Training; Resources; Rest; Risk; Risk-Taking; Structure; Symptoms; Teenagers; Theoretical Domains framework; Training; Transportation; Vehicle crash; brain behavior; burden of illness; catalyst; cerebrovascular; clinical practice; cognitive control; congenital heart disorder; data dissemination; design; distracted driving; driving behavior; driving safety; executive function; experience; functional near infrared spectroscopy; high risk; impaired driving performance; innovation; member; mortality; neurobehavioral; parent grant; peer; programs; simulation; skills; unsafe driving

Summary The population of adolescents with Congenital Heart Disease (CHD) has increased by nearly 65% since 2010. Like their healthy peers, adolescents with CHD may seek independence from their parents. Many pursue graduated drivers licensing (GDL) and experience newfound freedoms of independent driving. Driving is a complex task that relies on cognitive control and a high level of executive function. Motor vehicle crashes are common among adolescent first-year drivers. Crashes may be due in part to immature executive functioning. This immature function may be more profound among adolescents with CHD because they often have disease-related neurocognitive and neurobehavioral deficits. This presents a constellation of deficits similar to concussed adolescents. Therefore, risk for MVCs and related morbidity and mortality may be higher among concussed adolescents and adolescents with CHD. However, little is known about the association between complications of CHDs during adolescence and initial driving habits. This Administrative Supplement for R01NR018425 integrates a qualitative exploration of barriers and facilitators to safe independent driving from the perspective of adolescents with CHDs and parents (Aim 1) to address a critical gap in research and clinical practice. Aim 2 includes mentored training embedded in the Parent Grant that will help catalyze research training to set the stage for independent funding in the adolescent CHD population for the postdoctoral candidate. This Administrative Supplement is innovative because Aim 1 addresses a gap in scientific literature specific to initial driving experiences and builds upon the small body of literature that examines risk-taking behaviors among adolescents with CHD. Aim 2 provides an opportunity for the postdoctoral candidate to pursue conceptual and technical training in fNIRs during driving simulation, on-road data collection and ecological momentary assessment among concussed adolescents, as well as an opportunity to consider feasibility among adolescents with CHD in future research. This Administrative Supplement for R01NR018425 advances the field of pediatric cardiac research by identifying the types of driving behaviors and risks that adolescents with CHDs engage in and can be used as an example to describe similarities and differences when compared to adolescents without chronic cardiac disease. This mentored postdoctoral fellowship establishes an innovative foundation for future research initiatives that address the impact of risk-taking behavior on physiologic well-being in adolescents with CHD.

总结 患有先天性心脏病（CHD）的青少年人口增加了近 2010年以来的65%。像他们的健康同龄人一样，患有CHD的青少年可能会寻求独立， 他们的父母许多人追求毕业驾驶执照（GDL）和经验的新发现 独立驾驶的自由。驾驶是一项复杂的任务，依赖于认知控制和 高水平的执行功能。机动车事故在一年级青少年中很常见 司机崩溃可能部分是由于不成熟的执行功能。这个不成熟的功能 在青少年CHD患者中可能更严重，因为他们经常有疾病相关的 神经认知和神经行为缺陷。这就出现了一系列类似于 脑震荡的青少年因此，MVC的风险以及相关的发病率和死亡率可能是 在脑震荡青少年和患有冠心病的青少年中更高。然而， 关于青少年期冠心病并发症与初次驾驶之间的关系 习惯R01NR018425的本管理补充文件整合了以下定性探索： 从青少年的角度来看，安全独立驾驶的障碍和促进因素 CHD和父母（目标1），以解决研究和临床实践中的关键差距。目的2 包括嵌入在父母补助金中的指导培训，这将有助于促进研究 培训，为青少年CHD人群的独立资助奠定基础， 博士后候选人。本行政补充文件具有创新性，因为目标1涉及 科学文献中的空白，具体到最初的驾驶经验，并建立在小机构 研究青少年冠心病患者冒险行为的文献。目标2规定 博士后候选人有机会在以下方面进行概念和技术培训： 驾驶模拟、道路数据收集和生态瞬时评估期间的fNIR 在脑震荡的青少年，以及一个机会，考虑可行性， 青少年冠心病在未来的研究。R01NR018425的管理补充 通过识别驾驶行为的类型推进儿科心脏研究领域， 患有CHD的青少年所面临的风险，可以作为描述 与无慢性心脏病的青少年相比，有相似之处和差异。这 指导博士后奖学金为未来的研究奠定了创新基础 解决冒险行为对生理健康影响的举措， 青少年CHD