Epigenetic regulation of core centromere CENP-A chromatin integrity

核心着丝粒 CENP-A 染色质完整性的表观遗传调控

• 批准号: nhmrc : 1031872
• 负责人: A/Pr Lee Wong
• 金额: $ 21.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-core-chromatin-integrity/110827
• 关键词: Epigenetic; regulation; core; centromere; CENP

A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of attachment to the mitotic spindle. Defective centromeres can result in genome instability, infertility and development of cancers. This work involves a study into how the identity of a centromere is maintained and inherited after each cell division. This has significant implication in the understanding of cell growth and cancer development.

着丝粒是DNA的一个区域，通常位于染色体的中部附近，两个相同的姐妹染色单体接触。它作为有丝分裂纺锤体的附着点参与细胞分裂。有缺陷的着丝粒可导致基因组不稳定、不育和癌症的发展。这项工作涉及到一个着丝粒的身份是如何保持和遗传后，每次细胞分裂的研究。这对理解细胞生长和癌症发展具有重要意义。