Quantifying the role of lymphatics in lipid metabolism and transport
量化淋巴管在脂质代谢和运输中的作用
基本信息
- 批准号:8125092
- 负责人:
- 金额:$ 24.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-10 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimal ModelBiologyBloodCD36 geneCaveolinsCellsChylomicronsClinicalDiseaseEndothelial CellsEquilibriumFluid BalanceFunctional disorderGene Expression Microarray AnalysisGene SilencingHomeostasisImmuneIn VitroIntestinesKnockout MiceLinkLipidsLipoproteinsLow Density Lipoprotein ReceptorLymphaticLymphatic Endothelial CellsLymphatic EndotheliumLymphatic SystemLymphedemaMembraneMesenteryMethodsModelingNeoplasm MetastasisObesityPharmaceutical PreparationsPhaseProcessRNAResearchResearch Project GrantsResearch Project SummariesRoleSystemTechniquesTimeTissue EngineeringTissuesWorkabsorptiondesignin vitro Modelin vivoin vivo Modelinsightlipid metabolismlipid transportlymphatic circulationlymphatic pumpreceptortooltranscytosisuptake
项目摘要
Project Summary - Research in the lymphatic circulation is exciting and rich in challenges as its importance
in immune cell trafficl<ing, cancer metastasis, and lipid metabolism are quicl<ly becoming more appreciated
and as its active roles in such processes are only now being discovered. Because of the complexity of this
system, there is great need for new and quantitative tools and models to be developed, and to use those
new tools to explore these active roles in interdisciplinary manners. This proposal addresses the active role
of lymphatics in lipid transport and metabolism, a topic which is very poorly understood and for which very
few tools exist to study It. We will address these issues through three specific aims: 1) Identify and quantify
the role of key receptors and proteins involved in the transcytosis of lipid across lymphatic endothelial cells
using our previously developed tissue engineered model of the lacteal; 2) develop and characterize an in
vivo model of lymphatic uptake of lipid by mesenteric lymphatics and use this model to assess the
consequences of globally impaired lymphatic function (in knock-out mice) on lipid uptake by lymphatics; 3)
determine the effects of hyperiipidemia on lymphatic function (particularly the function of the intrinsic
lymphatic pump) using a combination of in vitro, in vivo, and isolated vessel models. Collectively these three
aims will investigate the balance of lipid and lymphatic function and provide new insight into the resulting
consequences of lymphatic or lipid dysfunction on lipid homeostasis and tissue fluid balance.
项目摘要 - 淋巴循环的研究令人兴奋,但因其重要性而充满挑战
在免疫细胞运输、癌症转移和脂质代谢中的作用很快变得越来越受到重视
而且它在这些过程中的积极作用现在才被发现。由于这个问题的复杂性
系统,非常需要开发新的定量工具和模型,并使用这些工具和模型
以跨学科方式探索这些积极作用的新工具。该提案强调了积极作用
淋巴管在脂质运输和代谢中的作用,这是一个人们知之甚少的话题,并且对此非常了解
很少有工具可以研究它。我们将通过三个具体目标来解决这些问题:1)识别和量化
参与脂质跨淋巴内皮细胞转胞吞作用的关键受体和蛋白质的作用
使用我们之前开发的乳腺组织工程模型; 2) 开发并表征
肠系膜淋巴管对脂质的淋巴摄取的体内模型,并使用该模型来评估
全面受损的淋巴功能(在基因敲除小鼠中)对淋巴管脂质摄取的影响; 3)
确定高脂血症对淋巴功能(特别是内在淋巴管功能)的影响
淋巴泵)使用体外、体内和分离血管模型的组合。这三者合起来
目标将调查脂质和淋巴功能的平衡,并为由此产生的结果提供新的见解
淋巴或脂质功能障碍对脂质稳态和组织液平衡的影响。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mechanisms of chylomicron uptake into lacteals.
- DOI:10.1111/j.1749-6632.2010.05716.x
- 发表时间:2010-10
- 期刊:
- 影响因子:5.2
- 作者:Dixon JB
- 通讯作者:Dixon JB
Demonstration of ATP-dependent, transcellular transport of lipid across the lymphatic endothelium using an in vitro model of the lacteal.
- DOI:10.1007/s11095-013-1218-x
- 发表时间:2013-12
- 期刊:
- 影响因子:3.7
- 作者:Reed, Alana L.;Rowson, Sydney A.;Dixon, J. Brandon
- 通讯作者:Dixon, J. Brandon
Lymphatic lipid transport: sewer or subway?
- DOI:10.1016/j.tem.2010.04.003
- 发表时间:2010-08
- 期刊:
- 影响因子:10.9
- 作者:Dixon, J. Brandon
- 通讯作者:Dixon, J. Brandon
Engineering the Lymphatic System.
工程淋巴系统。
- DOI:10.1007/s13239-011-0054-6
- 发表时间:2011
- 期刊:
- 影响因子:1.8
- 作者:Nipper,MatthewE;Dixon,JBrandon
- 通讯作者:Dixon,JBrandon
Differential transport function of lymphatic vessels in the rat tail model and the long-term effects of Indocyanine Green as assessed with near-infrared imaging.
- DOI:10.3389/fphys.2013.00215
- 发表时间:2013
- 期刊:
- 影响因子:4
- 作者:Weiler M;Dixon JB
- 通讯作者:Dixon JB
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{{ truncateString('James Brandon Dixon', 18)}}的其他基金
Quantifying the role of load-induced remodeling in lymphedema progression
量化负荷诱导的重塑在淋巴水肿进展中的作用
- 批准号:
8505748 - 财政年份:2013
- 资助金额:
$ 24.38万 - 项目类别:
Quantifying the role of load-induced remodeling in lymphedema progression
量化负荷诱导的重塑在淋巴水肿进展中的作用
- 批准号:
8851156 - 财政年份:2013
- 资助金额:
$ 24.38万 - 项目类别:
Quantifying the role of lymphatics in lipid metabolism and transport
量化淋巴管在脂质代谢和运输中的作用
- 批准号:
7930559 - 财政年份:2009
- 资助金额:
$ 24.38万 - 项目类别:
Quantifying the role of lymphatics in lipid metabolism and transport
量化淋巴管在脂质代谢和运输中的作用
- 批准号:
7929080 - 财政年份:2009
- 资助金额:
$ 24.38万 - 项目类别:
Quantifying the role of lymphatics in lipid metabolism and transport
量化淋巴管在脂质代谢和运输中的作用
- 批准号:
7531914 - 财政年份:2008
- 资助金额:
$ 24.38万 - 项目类别:
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