Brain integration of adiposity and satiety signals in the control of food intake

大脑整合肥胖和饱腹感信号来控制食物摄入

基本信息

  • 批准号:
    8119759
  • 负责人:
  • 金额:
    $ 24.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-01 至 2013-07-31
  • 项目状态:
    已结题

项目摘要

Obesity and related metabolic disorders have become a tremendous public health problem. This proposal Investigates the neural circuitry that Integrates input from the adiposity hormone leptin and the gut-derived satiety signals cholecystokinin (CCK) and glucagon-like peptlde-1 (GLP-1), and the physiological relevance ofthe interactions between these signals for the control of food Intake and body weight. Available data support the hypothesis that the adiposity hormone leptin reduces food Intake in part by enhancing satiety responses to gastrointestinal signals, Includingj CCK. We have recently determined that leptin Interacts In a sirnilar rrianrier with GLP-1, but our data suggest that the leptin-CCK and leptin-GLP-1 interactions are mediated through different neuronal pathways, Here, we propose to Identify and compare brain areas In which leptin detection Is sufficient to enhance the responses to GLP-1 and CCK, using site-speclfic microinjections and gene therapy In normal rats and rats that lack leptin receptors due to genetic mutation. Next, we will Investigate whether leptin reduces food Intake and enhances the satiety response to gastrointestinal nutrients in part by modulating rats' sensitivity to endogenously released GLP-1 or CCK. Finally, we will determine whether altered sensitivity to GLP-i or CCK plays a role in the pathogenesis of diet-Induced obesity when rats are maintained on a high-fat diet, which produces leptin resistance, together, these studies will help to clarify how changes In body fat stores lead to compensatory adjustments in meal size, as well as how defects In this process may lead to obesity and metabolic disorders, and thus have the potential to significantly advance our understanding ofthe neural control of feeding and body weight.
肥胖及相关代谢紊乱已成为一个巨大的公共卫生问题。本研究旨在研究整合肥胖激素瘦素和肠源性饱腹感信号胆囊收缩素(CCK)和胰高血糖素样肽-1 (GLP-1)输入的神经回路,以及这些信号之间相互作用与控制食物摄入和体重的生理相关性。现有数据支持肥胖激素瘦素减少食物摄入的假设,部分是通过增强对胃肠道信号的饱腹反应,包括CCK。我们最近确定瘦素在类似的河流中与GLP-1相互作用,但我们的数据表明,瘦素-CCK和瘦素-GLP-1相互作用是通过不同的神经通路介导的。在这里,我们建议在正常大鼠和由于基因突变而缺乏瘦素受体的大鼠中,使用位点特异性微注射和基因治疗,确定并比较瘦素检测足以增强对GLP-1和CCK反应的大脑区域。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neural integration of satiation and food reward: role of GLP-1 and orexin pathways.
  • DOI:
    10.1016/j.physbeh.2014.03.013
  • 发表时间:
    2014-09
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Williams DL
  • 通讯作者:
    Williams DL
Expecting to eat: glucagon-like peptide-1 and the anticipation of meals.
期待进食:胰高血糖素样肽-1 和对进餐的期待。
  • DOI:
    10.1210/en.2009-1372
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Williams,DianaL
  • 通讯作者:
    Williams,DianaL
Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake.
Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats.
  • DOI:
    10.1007/s00213-013-3248-9
  • 发表时间:
    2014-01
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Kay, Kristen;Parise, Eric M.;Lilly, Nicole;Williams, Diana L.
  • 通讯作者:
    Williams, Diana L.
Oxytocin action in the ventral tegmental area affects sucrose intake.
  • DOI:
    10.1016/j.brainres.2013.03.026
  • 发表时间:
    2013-06-04
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Mullis K;Kay K;Williams DL
  • 通讯作者:
    Williams DL
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Diana L Williams其他文献

Diana L Williams的其他文献

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{{ truncateString('Diana L Williams', 18)}}的其他基金

Neuroendocrine Integration of Satiety and Food Reward
饱腹感和食物奖励的神经内分泌整合
  • 批准号:
    8820912
  • 财政年份:
    2013
  • 资助金额:
    $ 24.65万
  • 项目类别:
Neuroendocrine Integration of Satiety and Food Reward
饱腹感和食物奖励的神经内分泌整合
  • 批准号:
    10359770
  • 财政年份:
    2013
  • 资助金额:
    $ 24.65万
  • 项目类别:
Neuroendocrine Integration of Satiety and Food Reward
饱腹感和食物奖励的神经内分泌整合
  • 批准号:
    8631083
  • 财政年份:
    2013
  • 资助金额:
    $ 24.65万
  • 项目类别:
Neuroendocrine Integration of Satiety and Food Reward
饱腹感和食物奖励的神经内分泌整合
  • 批准号:
    9020224
  • 财政年份:
    2013
  • 资助金额:
    $ 24.65万
  • 项目类别:
Neuroendocrine Integration of Satiety and Food Reward
饱腹感和食物奖励的神经内分泌整合
  • 批准号:
    8503884
  • 财政年份:
    2013
  • 资助金额:
    $ 24.65万
  • 项目类别:
Neuroendocrine Integration of Satiety and Food Reward
饱腹感和食物奖励的神经内分泌整合
  • 批准号:
    9234527
  • 财政年份:
    2013
  • 资助金额:
    $ 24.65万
  • 项目类别:
Brain integration of adiposity and satiety signals in the control of food intake
大脑整合肥胖和饱腹感信号来控制食物摄入
  • 批准号:
    8139452
  • 财政年份:
    2007
  • 资助金额:
    $ 24.65万
  • 项目类别:
Brain integration of adiposity and satiety signals in the control of food intake
大脑整合肥胖和饱腹感信号来控制食物摄入
  • 批准号:
    7300935
  • 财政年份:
    2007
  • 资助金额:
    $ 24.65万
  • 项目类别:
Brain integration of adiposity and satiety signals in the control of food intake
大脑整合肥胖和饱腹感信号来控制食物摄入
  • 批准号:
    7903217
  • 财政年份:
    2007
  • 资助金额:
    $ 24.65万
  • 项目类别:
Brain integration of adiposity and satiety signals in the control of food intake
大脑整合肥胖和饱腹感信号来控制食物摄入
  • 批准号:
    7487316
  • 财政年份:
    2007
  • 资助金额:
    $ 24.65万
  • 项目类别:

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