Molecular Biology and Gene Therapy in Burns and Trauma

烧伤和创伤的分子生物学和基因治疗

• 批准号: 8284328
• 负责人: LYLE L MOLDAWER
• 金额: $ 11.83万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8284328
• 关键词: Burn Trauma; gene therapy

The overall goal of this existing training program is to provide a focused 2-3 year research experience for up to two clinical residents-in- training (predominantly in surgery) expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy, as it applies to inflammation research. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics, gene therapy and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. The interface between molecular biology and inflammation research will be targeted to ARDS, sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, The faculty will be drawn from funded basic scientists in the Surgery, Obstetrics/ Gynecology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Anesthesiology , Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology, taking advantage of Ph.D. programs available to them, if appropriate.. Furthermore, trainees are expected to participate in seminars in the Powell Gene Therapy Center and Genetics Institute, and in their basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research. RELEVANCE (See instructions): Society recognizes the critical role that clinician-scientists play in translational biology and the application of new technologies to the clinic. We propose that a 2-3 year immersion by a young interested clinician in the laboratory of a successful basic scientist with expertise in molecular biology will provide a sound foundation for a career as a physician/scientist involved in translational research. The successful trainees will have the expertise in functional genomics, gene therapy and molecular biology to help translate the current genetic revolution to trauma practice.

这一现有培训计划的总体目标是为最多两个人提供2-3年的重点研究经验 临床住院医师培训(主要是外科)，表示致力于创伤、伤害、烧伤或 炎症研究。该研究计划将侧重于掌握分子生物学、功能基因组学和 基因疗法，因为它应用于炎症研究。这项计划将利用 医学院在不断扩大的功能基因组学、基因治疗和分子生物学领域，以及 基础科学家和临床医生之间的合作致力于培养未来的临床院士。这个 分子生物学和炎症研究之间的接口将针对ARDS、脓毒症综合征、 缺血/再灌注损伤、延迟创面愈合和烧伤创面，学院将从基金基础上抽调 外科、产科/妇科、分子遗传学和微生物学系的科学家，谁将 担任研修生的研究导师。外科、麻醉学、内科和病理学的临床导师 各部门将与受训人员和研究人员互动，以确保受训人员接触到 临床--炎症研究中的重要问题。该项目的总体指导将由校长负责 调查员和执行委员会。奖学金的候选人将在全国范围内和从 佛罗里达大学医学院。执行委员会的成功申请者将确定一项研究 和临床导师，他将帮助制定正式的培训计划，并定期审查受训人员的进度。这个 大部分培训计划将在经验丰富的研究导师的实验室进行，但受训人员也将 需要完成研究伦理和统计方法方面的基础课程工作，并将被鼓励获得 分子生物学方面的补充教学培训，利用他们可获得的博士课程，如果 适当的..。此外，预计受训人员将参加鲍威尔基因治疗中心的研讨会和 遗传学研究所、基础科学系以及实验室研究会议。他们也将成为 预计将参加临床研讨会，包括外科和重症监护医学大轮。预计 成功的毕业生将拥有足够的研究技能，以竞争炎症研究的过渡资金。 相关性(请参阅说明)： 社会认识到临床医生和科学家在翻译生物学和新技术的应用中所起的关键作用 将技术应用于临床。我们建议由一位对此感兴趣的年轻临床医生在 拥有分子生物学专业知识的成功基础科学家将为以后的职业生涯奠定坚实的基础 参与翻译研究的医生/科学家。成功的实习生将拥有职能部门的专业知识 基因组学、基因治疗和分子生物学，帮助将当前的基因革命转化为创伤实践。