Investigations of Human Auditory Mechanics
人类听觉机制的研究
基本信息
- 批准号:7982717
- 负责人:
- 金额:$ 15.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-01 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAnterior semicircular canal (body structure)AuditoryAuricular prosthesisClinicalCochleaConductive hearing lossDevicesDiseaseEarFunctional disorderGrantHearingHearing AidsHearing problemHumanIndividualInvestigationKnowledgeLabyrinthLesionLifeLiquid substanceMastoid processMeasurementMeasuresMechanicsMixed Conductive-Sensorineural Hearing LossMotionOperative Surgical ProceduresOval WindowPathologicPathologyPatientsPreparationPressure TransducersScala TympaniSemicircular canal structureSensoryShunt DeviceSideSimulateSpecimenStapedectomiesStapesStimulusSurgical PlugsSymptomsTechniquesTemporal bone structureTestingTravelalternative treatmentbaseboneclinical Diagnosisflexibilityfluid flowhearing impairmentinner ear diseasesmiddle earnovelpressurepublic health relevanceresearch studyround windowsample fixationsimulation
项目摘要
DESCRIPTION (provided by applicant): This grant seeks to address important clinical and scientific questions regarding human hearing diseases and their treatment. To do so, we make simultaneous pressure measurements on each side of the cochlear partition in human cadaveric temporal bones. This new and powerful technique enables direct determination of the differential pressure across the cochlear partition, the stimulus that excites the cochlear partition and initiates the cochlear traveling wave. Thus, this intracochlear differential pressure measurement in cadaveric temporal bones allows for a representation of what a live human with normal sensory function would hear, enabling us to investigate human hearing under controlled circumstances and to answer questions which could not be previously addressed, as outlined in the following 3 aims: Aim 1) Determine if a useful level of hearing is possible when the oval window is blocked and the cochlea is stimulated via the round window (RW). The experiments under this aim will establish whether or not RW stimulation can effectively treat stapes fixation in patients where stapedectomy is contraindicated. Furthermore, they will test the degree to which the cochlea can be approximated as a rigid bone containing incompressible fluid with only two flexible windows (oval and round windows) responsible for the pressure difference across the cochlear partition. Aim 2) Understand how pathologic third-window lesions of the inner ear can result in hearing loss. Superior semicircular canal dehiscence (SCD) is a prototypical third window lesion, and it is unknown why some individuals with SCD have hearing loss while others do not. By studying the impact of controlled dehiscences on differential pressure and other measurements, we will test two hypotheses: 1. Pathologic third windows shunt fluid flow away from the cochlea, resulting in decreased pressure difference across the cochlear partition, leading to hearing loss; 2. The size of the dehiscence is a major factor in the determination of the hearing loss. This study will aid in understanding when and how third-window lesions produce hearing loss and determine whether size of the dehiscence is an important variable. The present treatment for SCD is highly invasive and is reserved for debilitating vestibular symptoms only. A novel alternative treatment for SCD-induced hearing loss is addressed as part of Aim 3. Aim 3) Investigate the application of RW stimulation to treat various diseases of the middle and inner ear, including: 1. semicircular canal dehiscence; 2. discontinuity of the ossicular chain; 3. non-aerated middle ear; and 4. stapes fixation (as in Aim 1). By measuring the trans-cochlear differential pressure evoked by RW stimulation in the controlled setting of cadaveric preparations, while simulating various diseased states, we will investigate whether RW stimulation is a feasible and efficacious treatment for various middle- and inner-ear disorders. It is anticipated that the results of the investigations under these three aims will answer fundamental questions regarding human hearing, and yield advances in the clinical diagnosis and treatment of hearing diseases.
PUBLIC HEALTH RELEVANCE: This grant addresses mechanisms and treatments of middle- and inner-ear diseases that are common causes of hearing loss. A new measurement technique based on fiberoptic micro- pressure transducers will be employed in human cadaveric specimens to obtain previously unavailable knowledge and test new treatments.
描述(由申请者提供):这项资助旨在解决有关人类听力疾病及其治疗的重要临床和科学问题。为此,我们在人类身体颞骨的耳蜗区两侧同时进行了压力测量。这项新而强大的技术可以直接确定耳蜗区的压差,这是一种刺激耳蜗区并引发耳蜗波的刺激。因此,在身体的颞骨中,这种耳壳内压差的测量允许表示具有正常感觉功能的活人将听到的内容,使我们能够在受控的情况下调查人类的听力,并回答以前无法解决的问题,如以下3个目标所概述:目的1)确定当椭圆形窗被阻挡而耳蜗经圆窗(RW)被刺激时,是否有可能达到有用的听力水平。在这一目标下的实验将确定RW刺激是否能有效地治疗那些禁止切除STE的患者的STE固定。此外,他们还将测试耳蜗骨在多大程度上可以被近似为含有不可压缩流体的刚性骨骼,只有两个灵活的窗口(椭圆形和圆形窗口)负责耳蜗区的压力差。目的2)了解病理性内耳第三窗病变如何导致听力损失。上半规管裂开(SCD)是一种典型的第三窗病变,其原因尚不清楚。通过研究受控裂孔对差压和其他测量的影响,我们将检验两个假设:1.病理性第三窗将液体从耳蜗处分流,导致耳蜗区的压差降低,从而导致听力损失;2.裂孔的大小是确定听力损失的主要因素。这项研究将有助于了解第三窗口病变何时以及如何产生听力损失,并确定裂开的大小是否是一个重要的变量。目前对SCD的治疗是高度侵入性的,仅限于衰弱的前庭症状。目的3)探讨RW刺激在治疗各种中耳和内耳疾病中的应用,包括:1.半规管裂开;2.听骨链中断;3.非充气中耳;4.腓骨固定(与目标1相同)。通过在身体标本的受控环境中测量RW刺激引起的跨耳蜗压差,同时模拟各种疾病状态,我们将探讨RW刺激是否对各种中耳和内耳疾病是一种可行和有效的治疗方法。预计这三个目标下的研究结果将回答有关人类听力的基本问题,并在听力疾病的临床诊断和治疗方面取得进展。
公共卫生相关性:这笔赠款涉及中耳和内耳疾病的机制和治疗,这些疾病是听力损失的常见原因。一种基于光纤微压力传感器的新测量技术将被用于人体身体标本,以获得以前无法获得的知识,并测试新的治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Hideko Heidi Nakajima其他文献
Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual emre/em-sectioning: Potential implications for residual hearing
通过虚拟切片对人工耳蜗植入后纤维化和骨化的三维定量分析:对残余听力的潜在影响
- DOI:
10.1016/j.heares.2022.108681 - 发表时间:
2023-02-01 - 期刊:
- 影响因子:2.500
- 作者:
Alexander Geerardyn;MengYu Zhu;Peizhe Wu;Jennifer T. O'Malley;Joseph B. Nadol;M. Charles Liberman;Hideko Heidi Nakajima;Nicolas Verhaert;Alicia M. Quesnel - 通讯作者:
Alicia M. Quesnel
Hideko Heidi Nakajima的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Hideko Heidi Nakajima', 18)}}的其他基金
Mechanics of Human Middle & Inner Ear: Basic Science & Clinical Application
人体中部力学
- 批准号:
8650511 - 财政年份:2013
- 资助金额:
$ 15.4万 - 项目类别:
Mechanics of Human Middle & Inner Ear: Basic Science & Clinical Application
人体中部力学
- 批准号:
8735927 - 财政年份:2013
- 资助金额:
$ 15.4万 - 项目类别:
Mechanics of Human Middle & Inner Ear: Basic Science & Clinical Application
人体中部力学
- 批准号:
8901128 - 财政年份:2013
- 资助金额:
$ 15.4万 - 项目类别:
Middle-ear Mechanics in Normal and Pathological Ears
正常和病理耳朵的中耳力学
- 批准号:
8817270 - 财政年份:2001
- 资助金额:
$ 15.4万 - 项目类别: