Innovative Alcohol Intake Pattern Measurement for Human and Animal Model Research

用于人类和动物模型研究的创新酒精摄入模式测量

• 批准号: 8009272
• 负责人: Thomas K Greenfield
• 金额: $ 7.41万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009272
• 关键词: Acute; Address; Advisory Committees; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Animal Model; Basic Science; Biological; Biological Sciences; Blood alcohol level measurement; California; Clinical; Clinical Research; Collaborations; Communities; Country; Epidemiology; Etiology; Extramural Activities; Fertilization; Grant; Heart; Human; Institutes; Journals; Longevity; Measurement; Measures; Medical; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Patient Self-Report; Pattern; Physiological; Population; Prevention; Prevention Research; Public Health; Published Comment; Recommendation; Recording of previous events; Research; Research Priority; Sales; Science; System; Techniques; Time; Work; alcohol effect; alcohol exposure; alcohol research; alcohol use disorder; clinical epidemiology; falls; human population study; improved; innovation; innovative technologies; meetings; mortality; public health relevance; standardize measure; symposium

DESCRIPTION (provided by applicant): The National Alcohol Research Center (ARC) on the Epidemiology of Alcohol Problems at the Public Health Institute (PHI), Alcohol Research Group (ARG), Emeryville, CA (hereafter the Epidemiology Center or PHI Center), proposes to hold a Center Directors Meeting on the following topic: Innovative Alcohol Intake Pattern Measurement for Human and Animal Model Research on October 19 and 20, 2010 in Berkeley, California. This application for a R13 conference grant responds to PA-08-0149 and its theme is responsive to the first research priority recommendation made by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Extramural Advisory Committee, August 2006, intended to guide activities of the NIAAA Division of Epidemiology and Prevention: "Encourage systematic efforts to improve and standardize measures of patterns of alcohol exposure (acute, recent, or current history, and across the lifespan) and encourage their application across different grants, institutes, countries, and the medical system." A related recommendation focused on improving measurement of patterns of alcohol exposure to establish their effects on morbidity and mortality. While the PHI Epidemiology Center seeks to address these priorities in human and population studies, other Alcohol Research Centers focus on a wide range of topics involving biological, clinical, and community systems, including both human and animal model research. Recent advances have been made in self-report measurement of patterns of alcohol intake. Innovative technologies including physiological measures have been used to validate the new measures which have shown greater precision, coverage of national sales, and ability to predict alcohol dependence and acute harms. Similar advances are being made in measurement techniques in basic biomedical studies of alcohol effects. The meeting intends to bring together senior Alcohol Research Center leaders to examine and discuss the new work on alcohol consumption pattern measurement both in human population and clinical studies, and in animal model research that is at the heart of many of the advances in basic research on the etiology of alcohol use disorders (AUD). Our application at this time is prompted by an invitation from NIAAA to host the next Center Directors Meeting in the fall of 2010. The NIAAA has asked us to apply for the R13 Conference Grant for this purpose. The meeting would have a broad, multi- disciplinary viewpoint and engage the NIAAA and its Alcohol Research Centers in cutting-edge aspects of the topic we have selected. We plan to edit a special edition of a journal to collect the presentations at the meeting and bring them to a wider audience. PUBLIC HEALTH RELEVANCE: Relevance: It is timely to hold an interdisciplinary and translational meeting of senior Center leaders on alcohol pattern measurement that will cut across the fields of epidemiology, clinical and prevention research, and basic biological sciences relying on animal models. The cross fertilization and collaborations sparked will have the potential to accelerate the pace of science by sharing techniques of real-time ethanol intake measurement and indicators of blood alcohol level, crucial for better understanding alcohol-related morbidity and mortality.

描述(由申请人提供)： 位于加利福尼亚州埃默里维尔的公共卫生研究所(PHI)、酒精研究小组(ARG)的酒精问题流行病学国家酒精研究中心(ARC)(以下简称流行病学中心或PHI中心)提议于2010年10月19日和20日在加利福尼亚州伯克利举行一次关于以下主题的中心主任会议：人类和动物模型研究的创新酒精摄入模式测量。本次R13会议拨款申请响应了PA-08-0149，其主题是响应国家酒精滥用和酒精中毒研究所(NIAAA)校外咨询委员会于2006年8月提出的第一项优先研究建议，旨在指导NIAAA流行病和预防部门的活动：“鼓励系统地努力改进和标准化酒精暴露模式(急性、近期或当前历史，以及整个生命周期)的衡量标准，并鼓励它们在不同的赠款、机构、国家和医疗系统中应用。”一项相关建议侧重于改进酒精暴露模式的测量，以确定其对发病率和死亡率的影响。虽然PHI流行病学中心寻求在人类和人口研究中解决这些优先事项，但其他酒精研究中心专注于涉及生物、临床和社区系统的广泛主题，包括人类和动物模型研究。最近在酒精摄入模式的自我报告测量方面取得了进展。包括生理指标在内的创新技术已被用于验证新指标，这些指标显示出更高的精确度、全国销售覆盖率以及预测酒精依赖和急性伤害的能力。在酒精效应的基础生物医学研究中，测量技术也取得了类似的进展。这次会议旨在召集酒精研究中心的高级领导人，审查和讨论在人类人口和临床研究中的酒精消费模式测量以及动物模型研究方面的新工作，动物模型研究是酒精使用障碍(AUD)病因学基础研究的许多进展的核心。我们目前的申请是受到NIAAA的邀请，希望在2010年秋季主办下一届中心主任会议。NIAAA要求我们为此申请R13会议补助金。会议将有一个广泛的，多学科的观点，并让NIAAA及其酒精研究中心参与我们选择的主题的前沿方面。我们计划编辑一份期刊的特别版，收集会议上的演讲，并将它们带给更广泛的受众。 公共卫生相关性： 相关性：现在是时候召开一次关于酒精模式测量的跨学科和转换中心高级领导人会议，会议将横跨流行病学、临床和预防研究以及依赖动物模型的基础生物科学领域。引发的交叉受精和合作将有可能通过分享实时酒精摄入量测量技术和血液酒精水平指标来加快科学步伐，这对于更好地了解与酒精相关的发病率和死亡率至关重要。