XVII International Poxvirus, Asfivirus and Indorviurs Symposium

描述（由申请人提供）： 摘要 PI：JACOBS，BERTRAM L. 项目：1R13AI091299 - 01标题：第十七届国际痘病毒、阿斯菲病毒和虹彩病毒研讨会登录号：3255457 ================== 注意事项：本摘要摘自应用程序，未经SRA验证。当应用程序扫描过程出现问题时，提取的文本可能不正确或不完整。 ================== 此R13赠款提案提交给NIAID，以支持将于2010年6月5日至10日在亚利桑那州塞多纳的Poco Diablo度假村举行的第十八届国际痘病毒，Asfivirus和虹彩病毒研讨会。这是越来越多的从事痘和痘相关病毒研究的研究人员以及寻求更多地了解这些病毒对基础和医学科学影响的科学家的首要会议。2010年会议延续了每两年举行一次关于痘和痘相关病毒的研讨会的传统。预计2010年会议将吸引约225名与会者。科学计划将包括8场演讲，演讲者从以下主题领域提交的摘要中选出：（1）病毒进入，（2）病毒转录和基因表达，（3）病毒DNA生物学和基因组结构（包括基因组学和蛋白质组学），（4）病毒体组装和排出，（5）病毒宿主细胞相互作用和信号传导，（6）免疫调节和发病机制，（7）病毒载体和疫苗，以及（8）预防和治疗。科学计划委员会将从提交的摘要中选择演讲者，并将担任这些会议的讨论领导者。该计划还将包括两个海报会议。为了鼓励年轻科学家的职业发展，研究生和博士后的摘要将优先提交。美国政府通过NIH动员了各种努力，以制定有效的应对措施，应对有关天花和猴痘的公共卫生问题，并需要将痘病毒分子生物学的最新进展迅速转化为新的、安全有效的痘病毒感染治疗和预防策略。此外，最近在东欧出现的asfivirus和虹彩病毒作为世界范围内鱼类和两栖动物死亡的主要参与者的认识，使这成为一个独特的机会，汇集了对痘和痘相关病毒感兴趣的病毒学家，讨论我们在处理这些重要的人类和动物病原体方面的进展。最后，随着最近基于痘病毒的HIV疫苗方案的部分成功，人们对改进痘病毒作为疫苗载体重新产生了兴趣。第十八届国际痘病毒，Asfivirus和虹彩病毒研讨会的时机非常适合为讨论如何将对这些重要病毒的基础生物学的新理解转化为可以改善人类健康和粮食安全的方案提供场所，突出了研究界在应对新举措方面取得的进展，并继续吸引新的人才进入该领域。痘病毒引起人类天花和人类猴痘，痘相关病毒（asfiviruses和虹彩病毒）感染作为人类食物来源的重要生物。痘病毒也处于开发疫苗载体以对抗人类和动物疾病的最前沿。因此，第十八届国际痘病毒、阿斯菲病毒和虹彩病毒专题讨论会非常适合提供一个场所，讨论如何将对这些重要病毒的基本生物学的新认识转化为可以改善人类健康和粮食安全的方案。

DESCRIPTION (provided by applicant): Abstract PI: JACOBS, BERTRAM L. Project: 1R13AI091299-01 Title: XVII International Poxvirus, Asfivirus and Iridovirus Symposium Accession Number: 3255457 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This R13 grant proposal is submitted to NIAID for support of the XVIII International Poxvirus, Asfivirus and Iridovirus Symposium, to be held from June 5-10, 2010 at the Poco Diablo Resort in Sedona, AZ. This is the premier meeting for the growing community of researchers working on pox and pox-related viruses and for scientists seeking to learn more about the impact of these viruses on basic and medical science. The 2010 conference continues a tradition of workshop-style meetings on pox and pox-related viruses held every two years. The 2010 conference is expected to attract approximately 225 participants. The Scientific Program will consist of 8 sessions of oral presentations by speakers drawn from submitted abstracts in the following subject areas: (1) Virus entry, (2) Viral transcription and gene expression, (3) Viral DNA biology and genome structure (including genomics and proteomics), (4) Virion assembly and egress, (5) Virus host cell-interaction and signaling, (6) Immunomodulation and pathogenesis, (7) Viral vectors and vaccines, and (8) Prophylaxis and therapy. The Scientific Program Committee will select speakers from submitted abstracts and will serve as Discussion leaders for these sessions. The Program will also include two poster sessions. To encourage career development of junior scientists, abstracts from the ranks of graduate students and post-docs will be given priority for presentation. The US government, through NIH, has mobilized efforts to develop an effective response to the public health concerns regarding smallpox and monkeypox and the need to rapidly translate the recent advances in poxvirus molecular biology into new, safe and effective strategies for treatment and prophylaxis of poxvirus infections. In addition, the recent emergence of an asfivirus in Eastern Europe and the recognition of iridoviruses as central players in fish and amphibian mortalities world-wide, make this a unique opportunity to bring together the group of virologists interested in the pox and pox-related viruses to discuss our progress in dealing with these important human and animal pathogens. Finally, with the recent partial success of a poxvirus-based HIV vaccine regimen, there is renewed interest in improving poxviruses as vaccine vectors. The timing of the XVIII International Poxvirus, Asfivirus and Iridovirus Symposium is ideally tailored to providing a venue for discussions of how new understanding of the basic biology of these important viruses can be translated into regimens that can improve human health and food security, highlighting the advances achieved by the research community in response to new initiatives and to continue to draw new talent into the field. Poxviruses cause human smallpox and human monkeypox, and the pox-related viruses (asfiviruses and iridoviruses) infect organisms important as human food sources. Poxviruses are also in the forefront for development of vaccine vectors to fight human and animal diseases. Thus, the XVIII International Poxvirus, Asfivirus and Iridovirus Symposium is ideally suited to providing a venue for discussions of how new understanding of the basic biology of these important viruses can be translated into regimens that can improve human health and food security.