Monkeypox virus, Interferon, and Necroptosis

猴痘病毒、干扰素和坏死性凋亡

基本信息

项目摘要

Much of what we know about poxvirus innate immune evasion comes from work with the prototype orthopoxvirus, vaccinia virus (VACV). However, it is becoming clear that what we know for VACV is not always true for other poxviruses. The example we have been working on is monkeypox virus (MPXV). VACV has an E3L gene, which is essential for interferon-resistance, both in cells in culture and in the animal model. Despite being highly pathogenic, MPXV is missing 37 residues from the N-terminus of its E3 homologue. Thus, it is surprising that MPXV is as pathogenic as it is, despite missing this essential region of the E3 innate immune evasion protein. We have shown that while the lack of an N-terminal innate immune evasion domain in MPXV allows the virus to be sensed by the host, MPXV has evolved at least two apparently independent mechanisms to overcome the effects of being sensed in cells. The goals of this research are to understand how this unique human pathogen is sensed in infected cells and how it has evolved to counter the effects of sensing. Loss of this innate immune evasion domain makes vaccination against MPXV problematic. The final goal of this project is to develop a vaccine that can safely protect against MPXV infection.
我们对痘病毒先天性免疫逃避的了解大多来自于对痘病毒原型——牛痘病毒(VACV)的研究。然而,越来越清楚的是,我们对VACV的了解并不总是适用于其他痘病毒。我们一直在研究猴痘病毒(MPXV)的例子。在培养细胞和动物模型中,VACV具有E3L基因,该基因对干扰素耐药性至关重要。尽管具有高致病性,但MPXV在其E3同源物的n端缺失37个残基。因此,令人惊讶的是,尽管MPXV缺失了E3先天免疫逃避蛋白的这一重要区域,但它仍然具有致病性。我们已经证明,虽然MPXV中缺乏n端先天免疫逃避结构域允许病毒被宿主感知,但MPXV已经进化出至少两种明显独立的机制来克服在细胞中被感知的影响。这项研究的目的是了解这种独特的人类病原体是如何在感染细胞中被感知的,以及它是如何进化以对抗感知的影响的。这种先天免疫逃避结构域的缺失使得针对MPXV的疫苗接种存在问题。该项目的最终目标是开发一种可以安全地预防MPXV感染的疫苗。

项目成果

期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Detecting Necroptosis in Virus-Infected Cells.
A leader sequence capable of enhancing RNA expression and protein synthesis in mammalian cells.
能够增强哺乳动物细胞中 RNA 表达和蛋白质合成的前导序列。
Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response.
具有强大力量的小英雄:疫苗病毒E3蛋白和I型IFN反应的逃避。
  • DOI:
    10.3390/biomedicines10020235
  • 发表时间:
    2022-01-22
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Szczerba M;Subramanian S;Trainor K;McCaughan M;Kibler KV;Jacobs BL
  • 通讯作者:
    Jacobs BL
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
  • DOI:
    10.1126/scisignal.abq0837
  • 发表时间:
    2023-03-14
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
  • 通讯作者:
Use of a recombinant vaccinia virus expressing interferon gamma for post-exposure protection against vaccinia and ectromelia viruses.
  • DOI:
    10.1371/journal.pone.0077879
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Holechek SA;Denzler KL;Heck MC;Schriewer J;Buller RM;Legrand FA;Verardi PH;Jones LA;Yilma T;Jacobs BL
  • 通讯作者:
    Jacobs BL
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Bertram L. Jacobs其他文献

Proceedings of the Frontiers of Retrovirology Conference 2016
  • DOI:
    10.1186/s12977-016-0294-5
  • 发表时间:
    2016-09-26
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Irena Zurnic;Sylvia Hütter;Ute Lehmann;Nicole Stanke;Juliane Reh;Tobias Kern;Fabian Lindel;Gesche Gerresheim;Martin Hamann;Erik Müllers;Paul Lesbats;Peter Cherepanov;Erik Serrao;Alan Engelman;Dirk Lindemann;Claire Da Silva Santos;Kevin Tartour;Andrea Cimarelli;Rya Burdick;Jianbo Chen;Jaya Sastri;Wei-Shau Hu;Vinay Pathak;Oliver T. Keppler;Karine Pradeau;Sylvia Eiler;Nicolas Levy;Sarah Lennon;Sarah Cianferani;Stéphane Emiliani;Marc Ruff;Vincent Parissi;Sylvie Rato;Antonio Rausell;Miguel Munoz;Amalio Telenti;Angela Ciuffi;Alexander Zhyvoloup;Anat Melamed;Ian Anderson;Delphine Planas;Janos Kriston-Vizi;Robin Ketteler;Chen- Hsuin Lee;Andy Merritt;Petronela Ancuta;Charles Bangham;Ariberto Fassati;Anthony Rodari;Benoit Van Driessche;Mathilde Galais;Nadége Delacourt;Sylvain Fauquenoy;Caroline Vanhulle;Anna Kula;Arsène Burny;Olivier Rohr;Carine Van Lint;Thijs van Montfort;Renee van der Sluis;Dave Speijer;Ben Berkhout;Bo Meng;Andrzej Rutkowski;Neil Berry;Lars Dölken;Andrew Lever;Thomas Schuster;Benedikt Asbach;Ralf Wagner;Christine Gross;Veit Wiesmann;Martina Kalmer;Thomas Wittenberg;Jan Gettemans;Andrea K. Thoma-Kress;Minghua Li;Eric O. Freed;Shan-Lu Liu;Janis Müller;Jan Münch;Xaver Sewald;Pradeep Uchil;Mark Ladinsky;Jagadish Beloor;Ruoxi Pi;Christin Herrmann;Nasim Motamedi;Thomas Murooka;Michael Brehm;Dale Greiner;Thorsten Mempel;Pamela Bjorkman;Priti Kumar;Walther Mothes;Simone Joas;Erica Parrish;Clement Wesley Gnanadurai;Edina Lump;Christina M. Stürzel;Nicholas F. Parrish;Ulrike Sauermann;Katharina Töpfer;Tina Schultheiss;Steven Bosinger;Guido Silvestri;Cristian Apetrei;Nicholas Huot;Michaela Müller-Trutwin;Daniel Sauter;Beatrice H. Hahn;Christiane Stahl-Hennig;Frank Kirchhoff;Gerald Schumann;Sabine Jung-Klawitter;Nina V. Fuchs;Kyle R. Upton;Martin Muñoz-Lopez;Ruchi Shukla;Jichang Wang;Marta Garcia-Canadas;Cesar Lopez-Ruiz;Daniel J. Gerhardt;Attila Sebe;Ivana Grabundzija;Patricia Gerdes;Sylvia Merkert;Andres Pulgarin;Anja Bock;Ulrike Held;Anett Witthuhn;Alexandra Haase;Ernst J. Wolvetang;Ulrich Martin;Zoltán Ivics;Zsuzsanna Izsvák;J. Garcia-Perez;Geoffrey J. Faulkner;Tara Hurst;Aris Katzourakis;Gkikas Magiorkinis;Kerstin Schott;Rita Derua;Janna Seifried;Andreas Reuter;Heike Schmitz;Christiane Tondera;Alberto Brandariz-Nuñez;Felipe Diaz-Griffero;Veerle Janssens;Renate König;Hanna-Mari Baldauf;Lena Stegmann;Sarah-Marie Schwarz;Maud Trotard;Margarethe Martin;Gina Lenzi;Manja Burggraf;Xiaoyu Pan;Oliver I. Fregoso;Efrem S. Lim;Libin Abraham;Elina Erikson;Laura Nguyen;Ina Ambiel;Frank Rutsch;Baek Kim;Michael Emerman;Oliver T. Fackler;Sabine Wittmann;Rayk Behrendt;Bianca Volkmann;Kristin Eissmann;Thomas Gramberg;Sebastian Bolduan;Herwig Koppensteiner;Stefanie Regensburg;Ruth Brack-Werner;Rika Draenert;Michael Schindler;Aurélie Ducroux;Shuting Xu;Aparna Ponnurangam;Sergej Franz;Angelina Malassa;Ellen Ewald;Christine Goffinet;Sin-Yee Fung;Ching-Ping Chan;Chun-Kit Yuen;Kin-Hang Kok;Chin-Ping Chan;Dong-Yan Jin;Ulf Dittmer;Dorota Kmiec;Shilpa Iyer;Christina Stürzel;Beatrice Hahn;Yasuo Ariumi;Mariko Yasuda-Inoue;Koudai Kawano;Satoshi Tateishi;Priscilla Turelli;Alex Compton;Nicolas Roy;Françoise Porrot;Anne Billet;Nicoletta Casartelli;Jacob Yount;Chen Liang;Oliver Schwartz;Carsten Magnus;Lucia Reh;Penny Moore;Therese Uhr;Jacqueline Weber;Lynn Morris;Alexandra Trkola;Rashel V. Grindberg;Erika Schlaepfer;Gideon Schreiber;Viviana Simon;Roberto F. Speck;Zeger Debyser;Lenard Vranckx;Jonas Demeulemeester;Suha Saleh;Eric Verdin;Anna Cereseto;Frauke Christ;Rik Gijsbers;Gang Wang;Na Zhao;Atze T. Das;Josef Köstler;Beatriz Perdiguero;Mariano Esteban;Bertram L. Jacobs;David C. Montefiori;Celia C. LaBranche;Nicole L. Yates;Georgia D. Tomaras;Guido Ferrari;Kathryn E. Foulds;Mario Roederer;Gary Landucci;Donald N. Forthal;Michael S. Seaman;Natalie Hawkins;Steven G. Self;Sanjay Phogat;James Tartaglia;Susan W. Barnett;Brian Burke;Anthony D. Cristillo;Song Ding;Jonathan L. Heeney;Giuseppe Pantaleo;Viktoria Stab;Armin Ensser;Bettina Tippler;Dennis Burton;Matthias Tenbusch;Klaus Überla;Galit Alter;Giuseppe Lofano;Anne-Sophie Dugast;Viraj Kulkarni;Todd Suscovich;Tatiana Opazo;Felipe Barraza;Diego Herrera;Andrea Garces;Tomas Schwenke;Diego Tapia;Jorge Cancino;Gloria Arriagada;Christina Haußner;Dominik Damm;Anette Rohrhofer;Barbara Schmidt;Jutta Eichler;Rebecca Midgley;James Wheeldon;Vincent Piguet;Priyanka Khopkar;Megha Rohamare;Smita Kulkarni;Ana Godinho-Santos;Allan Hance;Joao Goncalves;Fabrizio Mammano;Romain Gasser;Meriem Hamoudi;Martina Pellicciotta;Zhicheng Zhou;Clara Visdeloup;Philippe Colin;Martine Braibant;Bernard Lagane;Matteo Negroni;Jula Wamara;Norbert Bannert;Thibault Mesplede;Nathan Osman;Kaitlin Anstett;Jiaming Calvin Liang;Hanh Thi Pham;Mark Wainberg;Wei Shao;Jigui Shan;Mary Kearney;Xiaolin Wu;Frank Maldarelli;John Mellors;Brian Luke;John Coffin;Stephen Hughes;Thomas Fricke;Silvana Opp;Caitlin Shepard;Dmitri Ivanov;Jose Valle-Casuso;Marine Kanja;Pierre Cappy;Matteo Negroni;Daniela Lener;Ekaterina Knyazhanskaya;Andrey Anisenko;Timofey Zatsepin;Marina Gottikh;Alexander Komkov;Anastasia Minervina;Gaiaz Nugmanov;Vadim Nazarov;Konstantin Khodosevich;Ilgar Mamedov;Yuri Lebedev;Marta Colomer-Lluch;Ruth Serra-Moreno;Ambra Sarracino;Lavina Gharu;Alexander Pasternak;Alessandro Marcello;Ann Marie McCartin;Anurag Kulkarni;Valentin Le Douce;Virginie Gautier;Ann Baeyens;Evelien Naessens;Anouk Van Nuffel;Karin Weening;Anne- Marie Reilly;Eva Claeys;Wim Trypsteen;Linos Vandekerckhove;Sven Eyckerman;Kris Gevaert;Bruno Verhasselt;Hoi Ping Mok;Nicholas Norton;Axel Fun;Jack Hirst;Mark Wills;Dalibor Miklik;Filip Senigl;Jiri Hejnar;Jun-ichi Sakuragi;Sayuri Sakuragi;Masaru Yokoyama;Tatsuo Shioda;Hironori Sato;Jochen Bodem;Rebecca Moschall;Sarah Denk;Steffen Erkelenz;Christian Schenk;Heiner Schaal;Norbert Donhauser;Ellen Socher;Sebastian Millen;Heinrich Sticht;Christine Gross;Melanie Mann;Guochao Wei;Matthew J. Betts;Yang Liu;Timo Kehl;Robert B. Russell;Martin Löchelt;Oliver Hohn;Saeed Mostafa;Kirsten Hanke;Stephen Norley;Chia-Yen Chen;Masashi Shingai;Pedro Borrego;Nuno Taveira;Klaus Strebel;Chris Hellmund;Bo Meng;Melanie Friedrich;Friedrich Hahn;Christian Setz;Pia Rauch;Kirsten Fraedrich;Alina Matthaei;Petra Henklein;Maximilian Traxdorf;Torgils Fossen;Ulrich Schubert;Aya Khwaja;Meytal Galilee;Akram Alian;Birco Schwalbe;Heiko Hauser;Michael Schreiber;Mirte Scherpenisse;Young-Keol Cho;Jungeun Kim;Daeun Jeong;Katerina Trejbalova;Martina Benesova;Dana Kucerova;Zdenka Vernerova;Rachel Amouroux;Petra Hajkova;Daniel Elleder;Tomas Hron;Helena Farkasova;Abinash Padhi;Jan Paces;Henan Zhu;Robert Gifford;Pablo Murcia;Maria Luisa Carrozza;Anna-Maria Niewiadomska;Maurizio Mazzei;Mounir Abi-Said;Joseph Hughes;Stéphane Hué;Robert Gifford;Adetayo Obasa;Graeme Jacobs;Susan Engelbrecht;Katharina Mack;Kathrin Starz;Matthias Geyer;Frederic Bibollet-Ruche;Christina Stürzel;Marie Leoz;Jean Christophe Plantier;Ayele Argaw-Denboba;Emanuela Balestrieri;Annalucia Serafino;Ilaria Bucci;Chiara Cipriani;Corrado Spadafora;Paolo Sinibaldi-Vallebona;Claudia Matteucci;S. Nandi Jayashree;Ujjwal Neogi;Anil K. Chhangani;Shravan Sing Rathore;Bajrang R. J. Mathur;Adeyemi Abati;B. Taylan Koç;Tuba Çiğdem Oğuzoğlu;Takatoshi Shimauchi;Stephan Caucheteux;Jocelyn Turpin;Katja Finsterbusch;Yoshiki Tokura;Shanti Souriant;Luciana Balboa;Karine Pingris;Denise Kviatcowsky;Brigitte Raynaud-Messina;Céline Cougoule;Ingrid Mercier;Marcelo Kuroda;Pablo González-Montaner;Sandra Inwentarz;Eduardo Jose Moraña;Maria del Carmen Sasiain;Olivier Neyrolles;Isabelle Maridonneau-Parini;Geanncarlo Lugo-Villarino;Christel Vérollet;Alexandra Herrmann;Dominique Thomas;Nerea Ferreirós Bouzas;Xavier Lahaye;Anvita Bhargava;Takeshi Satoh;Matteo Gentili;Silvia Cerboni;Aymeric Silvin;Cécile Conrad;Hakim Ahmed-Belkacem;Elisa C. Rodriguez;Jean-François Guichou;Nathalie Bosquet;Matthieu Piel;Roger Le Grand;Megan King;Jean-Michel Pawlotsky;Nicolas Manel;Henning Hofmann;Benedicte Vanwalscappel;Nicolin Bloch;Nathaniel Landau;Stanislav Indik;Benedikt Hagen;José Carlos Valle-Casuso;Awatef Allouch;Annie David;Françoise Barré-Sinoussi;Monsef Benkirane;Gianfranco Pancino;Asier Saez-Cirion;Wing-Yiu Lee;Richard Sloan;Bianca Schulte;Silvana Opp;Jonas Blomberg;Luana Vargiu;Patricia Rodriguez-Tomé;Enzo Tramontano;Göran Sperber;Namita Kumari;Tatiana Ammosova;Sharmeen Diaz;Patricia Oneal;Sergei Nekhai;Audrey Fahrny;Gustavo Gers-Huber;Annette Audigé;Anitha Jayaprakash;Ravi Sachidanandam;Matt Hernandez;Marsha Dillon-White;Shanti Souriant;Karine Pingris;Brigitte Raynaud-Messina;Céline Cougoule;Ingrid Mercier;Olivier Neyrolles;Isabelle Maridonneau-Parini;Geanncarlo Lugo-Villarino;Emmanuel Maze;Claire Ham;Neil Almond;Greg Towers;Robert Belshaw;Patrícia de Sousa-Pereira;Joana Abrantes;Massimo Pizzato;Pedro J. Esteves;Tanja Kahle;Sven Schmitt;Laura Merkel;Nina Reuter;Thomas Stamminger;Ilaria Dalla Rosa;Kate Bishop;Antonella Spinazzola;Harriet Groom;Gabrielle Vieyres;Mathias Müsken;Thomas Zillinger;Veit Hornung;Winfried Barchet;Susanne Häussler;Thomas Pietschmann;Aneela Javed;Nicole Leuchte;Gabriela Salinas;Lennart Opitz;Sieghart Sopper;Christiane Mummert;Christian Hofmann;Angela G. Hückelhoven;Silke Bergmann;Sandra M. Müller-Schmucker;Ellen G. Harrer;Jan Dörrie;Niels Schaft;Thomas Harrer;Laure Cardinaux;M.- L. Zahno;H.- R. Vogt;R. Zanoni;G. Bertoni;Maximilian Muenchhoff;Philip Goulder;Oliver Keppler;Stephanie Rebensburg;Markus Helfer;Yuwei Zhang;Huicheng Chen;Annie Bernier;Annie Gosselin;Jean- Pierre Routy;Birgitta Wöhrl;Anna Schneider;Angela Corona;Imke Spöring;Mareike Jordan;Bernd Buchholz;Elias Maccioni;Roberto Di Santo;Kristian Schweimer;Christian Schölz;Brian Weinert;Sebastian Wagner;Petra Beli;Yasuyuki Miyake;Jun Qi;Lars Jensen;Werner Streicher;Anna McCarthy;Nicholas Westwood;Sonia Lain;Jürgen Cox;Patrick Matthias;Matthias Mann;James Bradner;Chunaram Choudhary;Marcel Stern;Elena Valletta;Caterina Frezza;Francesca Marino-Merlo;Sandro Grelli;Anna Lucia Serafino;Antonio Mastino;Beatrice Macchi;Meike Kaulfuß;Sonja Windmann;Wibke Bayer;Sello Mikasi;Graeme Jacobs;Rebecca Heß;Michael Storcksdieck gen. Bonsmann;Carsten Kirschning;Bernd Lepenies;Anne Kolenbrander;Vladimir Temchura;Kenta Iijima;Junya Kobayashi;Yukihito Ishizaka
  • 通讯作者:
    Yukihito Ishizaka
79 Viral Regulation of the PKR Innate Response by Specific Proteolytic Targeting
  • DOI:
    10.1016/j.cyto.2007.07.084
  • 发表时间:
    2007-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jeffrey O. Langland;Bertram L. Jacobs
  • 通讯作者:
    Bertram L. Jacobs
Gene Modulatory Effects, Pharmacokinetics, and Clinical Tolerance of Interferon‐α1b: A Second Member of the Interferon‐α Family
干扰素-α1b 的基因调节作用、药代动力学和临床耐受性:干扰素-α 家族的第二个成员
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    P. Masci;Thomas Olencki;Laura S. Wood;Lisa Rybicki;Bertram L. Jacobs;Bryan R.G. Williams;Pieter W. Faber;R. Bukowski;K. Tong;Ernest C. Borden
  • 通讯作者:
    Ernest C. Borden

Bertram L. Jacobs的其他文献

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{{ truncateString('Bertram L. Jacobs', 18)}}的其他基金

Monkeypox virus, Interferon, and Necroptosis
猴痘病毒、干扰素和坏死性凋亡
  • 批准号:
    10241530
  • 财政年份:
    2012
  • 资助金额:
    $ 41.83万
  • 项目类别:
DsRNA Characterization in Monkeypox-infected Cells
猴痘感染细胞中的 DsRNA 表征
  • 批准号:
    8372121
  • 财政年份:
    2012
  • 资助金额:
    $ 41.83万
  • 项目类别:
Monkeypox virus, Interferon, and Necroptosis
猴痘病毒、干扰素和坏死性凋亡
  • 批准号:
    10455608
  • 财政年份:
    2012
  • 资助金额:
    $ 41.83万
  • 项目类别:
DsRNA Characterization in Monkeypox-infected Cells
猴痘感染细胞中的 DsRNA 表征
  • 批准号:
    8653927
  • 财政年份:
    2012
  • 资助金额:
    $ 41.83万
  • 项目类别:
Monkeypox virus, Interferon, and Necroptosis
猴痘病毒、干扰素和坏死性凋亡
  • 批准号:
    10052748
  • 财政年份:
    2012
  • 资助金额:
    $ 41.83万
  • 项目类别:
DsRNA Characterization in Monkeypox-infected Cells
猴痘感染细胞中的 DsRNA 表征
  • 批准号:
    8473158
  • 财政年份:
    2012
  • 资助金额:
    $ 41.83万
  • 项目类别:
XVII International Poxvirus, Asfivirus and Indorviurs Symposium
第十七届国际痘病毒、阿斯菲病毒和 Indorviurs 研讨会
  • 批准号:
    8006015
  • 财政年份:
    2010
  • 资助金额:
    $ 41.83万
  • 项目类别:
Disabling Vaccinia IFNr: A New Smallpox Vaccine
禁用痘苗 IFNr:一种新的天花疫苗
  • 批准号:
    7491011
  • 财政年份:
    2005
  • 资助金额:
    $ 41.83万
  • 项目类别:
Development of a post-exposure vaccine for smallpox
天花暴露后疫苗的开发
  • 批准号:
    6998645
  • 财政年份:
    2005
  • 资助金额:
    $ 41.83万
  • 项目类别:
Disabling Vaccinia IFNr: A New Smallpox Vaccine
禁用痘苗 IFNr:一种新的天花疫苗
  • 批准号:
    7091654
  • 财政年份:
    2005
  • 资助金额:
    $ 41.83万
  • 项目类别:

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脱细胞小直径动脉移植物的研制及大动物实验评价
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Never replicate a successful experiment? Standardization, heterogenization and reproducibility in animal experiments
从未复制过成功的实验?
  • 批准号:
    283089959
  • 财政年份:
    2015
  • 资助金额:
    $ 41.83万
  • 项目类别:
    Research Grants
Arrhythmogenic Drug Evaluation System by Simplified Animal Experiments
简化动物实验的致心律失常药物评价系统
  • 批准号:
    26350520
  • 财政年份:
    2014
  • 资助金额:
    $ 41.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Promotion of the 4Rs in animal experiments by the development of a production process for polyclonal antibodies using a goldfish
开发金鱼多克隆抗体生产工艺,促进动物实验中的4R
  • 批准号:
    23650227
  • 财政年份:
    2011
  • 资助金额:
    $ 41.83万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of microangiographic systems to visualize cerebular perforating artery in clinical settings and retrobulbar ophthalmic artery arteries in animal experiments.
开发显微血管造影系统,以在临床环境中可视化小脑穿支动脉,并在动物实验中可视化球后眼动脉。
  • 批准号:
    23390305
  • 财政年份:
    2011
  • 资助金额:
    $ 41.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The study for the modification of cerebral synapses by balance exercises in the elderly based on animal experiments.
基于动物实验的老年人平衡运动改变大脑突触的研究。
  • 批准号:
    21500471
  • 财政年份:
    2009
  • 资助金额:
    $ 41.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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