2010 Cell and Molecular Fungal Biology; Gordon Research Conference

2010 细胞与分子真菌生物学；

• 批准号: 7905513
• 负责人: JOHN W. TAYLOR
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905513
• 关键词: Address; Animal Model; Aspergillosis; Biology; Candidiasis; Cells; Coccidioidomycosis; Communities; Complex; Cytoskeleton; Development; Disease; Effectiveness; Evaluation; Genomics; Germination; Goals; Growth; Health; Histoplasmosis; Human; International; Knowledge; Life; Membrane Protein Traffic; Molecular; Motor; National Institute of Allergy and Infectious Disease; National Institute of General Medical Sciences; Oral; Participant; Pathogenesis; Pharmacologic Substance; Play; Population; Prevention; Process; Reproduction; Reproduction spores; Request for Proposals; Research; Research Personnel; Role; Schools; Small RNA; Speed; Symbiosis; Systems Biology; Transplant Recipients; United States National Institutes of Health; design; distraction; fungus; human disease; interest; meetings; posters; symposium; vaccine candidate

DESCRIPTION (provided by applicant): This proposal requests partial support for the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 13-18, 2010. The broad and long-term goal of the conference is to spread information about fungal biology among researchers to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are excellent eukaryotic model organisms, so much of the conference will be central to the aims of NIH- National Institute of General Medical Science. Fungi cause significant human disease; so much of the research presented will address the interests of the NIH-National Institute of Allergy and Infectious Disease. The specific aim of this meeting will be to convene 52 speakers who represent the leading edge of fungal research with a total of ca. 130- 140 participants, most of whom will present posters, for a five-day conference in a setting with few distractions. The oral and poster sessions are designed to emphasize discussion and networking, and evaluations from past conferences demonstrate the effectiveness of this format. The 2010 meeting will combine topics new to this conference, e.g., systems biology, small RNA, population genomics, with topics of enduring significance, e.g., pathogenesis, symbiosis, membrane trafficking, and cytoskeleton and motors. The significance of this application is the demonstrated effect of this conference in accelerating research in the international fungal biology community, including prevention and treatment of disease. The health relatedness of this application centers on the role of fungi in human disease, including two of the most important diseases of transplant patients, candidiasis and aspergillosis, and the systemic fungal diseases, coccidioidomycosis and histoplasmosis. The health relatedness of this application concerns both the role that fungi play in human disease and the role that fungi play in understanding the fundamental features of eukaryotic biology. Knowledge of the biology of fungi is essential to the prevention of fungal disease by illuminating basic features of fungal development, including spore germination, colony establishment, growth, and reproduction. This knowledge is also essential to treatment of fungal disease by identifying targets for pharmaceuticals and molecular candidates for vaccines. Use of fungi as model organisms continues to speed our understanding of basic features of all complex life, including humans, through study of basic cellular and molecular processes.

描述（由申请人提供）：本提案请求部分支持将于 2010 年 6 月 13 日至 18 日在霍尔德内斯学院举行的戈登细胞和分子真菌生物学研究会议。会议的广泛和长期目标是在研究人员中传播有关真菌生物学的信息，以增加我们对基础真菌生物学及其在社会重要问题中的应用的集体理解。真菌是优秀的真核模型生物，因此会议的大部分内容将成为 NIH（美国国立普通医学科学研究所）目标的核心。真菌导致严重的人类疾病；所提出的大部分研究都将涉及 NIH 国家过敏和传染病研究所的利益。本次会议的具体目标是召集 52 名代表真菌研究前沿的发言人，总计约 10 名。为期五天的会议将有 130 至 140 名与会者参加，其中大多数人将展示海报，会议的环境几乎没有干扰。口头会议和海报会议旨在强调讨论和交流，过去会议的评估证明了这种形式的有效性。 2010 年会议将结合本次会议的新主题（例如系统生物学、小 RNA、群体基因组学）和具有持久意义的主题（例如发病机制、共生、膜运输以及细胞骨架和马达）。此次申请的意义在于展示了本次会议在加速国际真菌生物学界的研究，包括疾病的预防和治疗方面的效果。该应用程序的健康相关性集中于真菌在人类疾病中的作用，包括移植患者的两种最重要的疾病：念珠菌病和曲霉菌病，以及系统性真菌病：球孢子菌病和组织胞浆菌病。该应用的健康相关性涉及真菌在人类疾病中所起的作用以及真菌在理解真核生物学的基本特征中所起的作用。了解真菌生物学知识对于通过阐明真菌发育的基本特征（包括孢子萌发、菌落建立、生长和繁殖）来预防真菌病至关重要。这些知识对于通过确定药物靶标和疫苗候选分子来治疗真菌病也至关重要。通过研究基本的细胞和分子过程，使用真菌作为模式生物继续加速我们对包括人类在内的所有复杂生命的基本特征的理解。