2010 Cell and Molecular Fungal Biology; Gordon Research Conference

2010 细胞与分子真菌生物学；

• 批准号: 7905513
• 负责人: JOHN W. TAYLOR
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905513
• 关键词: Address; Animal Model; Aspergillosis; Biology; Candidiasis; Cells; Coccidioidomycosis; Communities; Complex; Cytoskeleton; Development; Disease; Effectiveness; Evaluation; Genomics; Germination; Goals; Growth; Health; Histoplasmosis; Human; International; Knowledge; Life; Membrane Protein Traffic; Molecular; Motor; National Institute of Allergy and Infectious Disease; National Institute of General Medical Sciences; Oral; Participant; Pathogenesis; Pharmacologic Substance; Play; Population; Prevention; Process; Reproduction; Reproduction spores; Request for Proposals; Research; Research Personnel; Role; Schools; Small RNA; Speed; Symbiosis; Systems Biology; Transplant Recipients; United States National Institutes of Health; design; distraction; fungus; human disease; interest; meetings; posters; symposium; vaccine candidate

DESCRIPTION (provided by applicant): This proposal requests partial support for the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 13-18, 2010. The broad and long-term goal of the conference is to spread information about fungal biology among researchers to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are excellent eukaryotic model organisms, so much of the conference will be central to the aims of NIH- National Institute of General Medical Science. Fungi cause significant human disease; so much of the research presented will address the interests of the NIH-National Institute of Allergy and Infectious Disease. The specific aim of this meeting will be to convene 52 speakers who represent the leading edge of fungal research with a total of ca. 130- 140 participants, most of whom will present posters, for a five-day conference in a setting with few distractions. The oral and poster sessions are designed to emphasize discussion and networking, and evaluations from past conferences demonstrate the effectiveness of this format. The 2010 meeting will combine topics new to this conference, e.g., systems biology, small RNA, population genomics, with topics of enduring significance, e.g., pathogenesis, symbiosis, membrane trafficking, and cytoskeleton and motors. The significance of this application is the demonstrated effect of this conference in accelerating research in the international fungal biology community, including prevention and treatment of disease. The health relatedness of this application centers on the role of fungi in human disease, including two of the most important diseases of transplant patients, candidiasis and aspergillosis, and the systemic fungal diseases, coccidioidomycosis and histoplasmosis. The health relatedness of this application concerns both the role that fungi play in human disease and the role that fungi play in understanding the fundamental features of eukaryotic biology. Knowledge of the biology of fungi is essential to the prevention of fungal disease by illuminating basic features of fungal development, including spore germination, colony establishment, growth, and reproduction. This knowledge is also essential to treatment of fungal disease by identifying targets for pharmaceuticals and molecular candidates for vaccines. Use of fungi as model organisms continues to speed our understanding of basic features of all complex life, including humans, through study of basic cellular and molecular processes.

描述（由申请人提供）：本提案要求部分支持将于2010年6月13日至18日在Holderness学校举行的戈登细胞和分子真菌生物学研究会议。会议的长远目标是在研究人员之间传播有关真菌生物学的信息，以增加我们对基本真菌生物学的集体理解及其在社会重要问题上的应用。真菌是优秀的真核模式生物，因此会议的大部分内容将是NIH-国家普通医学科学研究所的核心目标。真菌引起严重的人类疾病；因此，所提出的许多研究都将涉及美国国立卫生研究院——国家过敏和传染病研究所的利益。本次会议的具体目标是召集52位代表真菌研究前沿的演讲者，总共约130- 140名与会者，其中大多数人将展示海报，为期五天，几乎没有分心的会议。口头会议和海报会议旨在强调讨论和网络，过去会议的评价证明了这种形式的有效性。2010年会议将结合本次会议的新主题，如系统生物学、小RNA、群体基因组学，以及具有持久意义的主题，如发病机制、共生、膜运输、细胞骨架和马达。这一应用的意义在于这次会议在加速国际真菌生物学界的研究，包括疾病的预防和治疗方面的效果。该应用的健康相关性集中在真菌在人类疾病中的作用上，包括移植患者最重要的两种疾病，念珠菌病和曲霉病，以及全身真菌疾病，球孢子菌病和组织浆菌病。这一应用的健康相关性涉及真菌在人类疾病中所起的作用以及真菌在理解真核生物基本特征方面所起的作用。真菌的生物学知识是必不可少的，通过阐明真菌发育的基本特征，包括孢子萌发、菌落建立、生长和繁殖，预防真菌疾病。这一知识对于通过确定药物靶点和疫苗候选分子来治疗真菌疾病也是必不可少的。利用真菌作为模式生物，通过研究基本的细胞和分子过程，继续加速我们对包括人类在内的所有复杂生命的基本特征的理解。