TRANSLATIONAL STRATEGIES FOR PANCREATIC ISLET XENOTRANSPLANTATION IN NHP

NHP 胰岛异种移植的翻译策略

• 批准号: 7958244
• 负责人: CHRISTIAN P LARSEN
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958244
• 关键词: Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Family suidae; Foundations; Funding; Grant; Hyperglycemia; Immunosuppression; Institution; Islets of Langerhans; Islets of Langerhans Transplantation; Macaca; Methods; Modeling; Neonatal; Pharmaceutical Preparations; Primates; Problem Solving; Process; Reporting; Research; Research Personnel; Resolution; Resources; Site; Source; Streptozocin; Transplantation; Treatment Protocols; United States National Institutes of Health; Xenograft procedure; base; clinically relevant; diabetic; experience; implantation; islet; nonhuman primate; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past year, we solved the problem of reduced success experienced during the previous report period. After resolving a number of technical problems involving the isolation and processing of the neonatal porcine islets, and a new nonhuman primate diabetes induction method by streptozocin, we have been able to reproduce our original success of transplanting porcine islets into recipient diabetic macaques with sustained resolution of hyperglycemia and survival of porcine islets for 180 days under cover of a costimulation blockade-based immunosuppression regimen. Guided by success in our alloislet nonhuman primate model, more favorable and clinically relevant treatment protocols were applied to our xenoislet model with very promising results. Once optimized, the new drug regimen will be used to determine the optimal islet mass and implantation site, establishing a foundation for moving porcine islet transplantation into clinical trials.

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