Core-001

核心001

• 批准号: 10609609
• 负责人: CHRISTIAN P LARSEN
• 金额: $ 35.71万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609609
• 关键词: Address; Biological Assay; Cellular Immunology; Chronic; Clinical; Collaborations; Complex; Development; Elements; Flow Cytometry; Goals; Histopathology; Immune Tolerance; Immunity; Immunogenetics; Immunosuppression; Infection; Kidney Transplantation; Life; Maintenance; Molecular Immunology; Molecular Virology; Patient-Focused Outcomes; Procedures; Public Health; Research; Research Personnel; Services; Transplantation Tolerance; Virus; experimental study; improved; member; nonhuman primate

This U19 Consortium benefits from an integrated approach to performing non-human primate (NHP) transplant tolerance research. The hub of this integration is the Molecular and Cellular Immunology Core (MCIC), which coordinates and streamlines all common assays and procedures, as well as the NHP MHC typing needs for all members of this U19 collaborative group. The MCIC is comprised of five interacting elements: (1) The MHC Immunogenetics and Typing Core, (2) the Flow Cytometry Core, (3) the NHP Histopathology Core, (4) the Molecular Immunology and Virology Core, and (5) the Functional Protective Immunity Core. Each Core addresses a critical need for the conduct of the complex experiments that are proposed in each of the projects and promotes collaboration between investigators. As such, the development of these integrated services has significantly increased the efficiency and the rigor with which our group is able to execute complex NHP transplantation tolerance research.

这个U19联盟受益于对非人类灵长类动物(NHP)的综合研究 移植耐受研究。这种整合的枢纽是分子和细胞免疫学核心 (MCIC)，它协调和简化所有常见的分析和程序，以及NHP MHC 这个U19协作组的所有成员都需要打字。MCIC由五个相互作用的 要素：(1)MHC免疫遗传学和分型核心，(2)流式细胞仪核心，(3)NHP 组织病理学核心，(4)分子免疫学和病毒学核心，(5)功能保护剂 豁免核心。每个核心都满足了进行复杂实验的关键需求，这些实验 在每个项目中都提出了建议，并促进了调查人员之间的合作。因此， 这些集成服务的开发显著提高了效率和严谨程度 我们的团队能够进行复杂的NHP移植耐受研究。