Hollow Fiber Production of Monoclonal Antibodies

中空纤维mab的生产利用纤维细胞系统模块和专门的泵来迫使液体介质通过一束半透性纤维。高度浓缩的单克隆抗体保留在腔室中，直接从纤维中利用，或根据研究者的需要进一步处理。如果单克隆抗体直接用于动物，则使用特殊的无蛋白培养基。通过标准组织培养技术产生的抗体使用塑料瓶和标准培养基。2008财年共培养了8个单克隆抗体，产生近30克抗体。(草案)

The production of hollow fiber MABs utilizes a Fiber Cell System module and a specialized pump to force liquid media through a bundle of semi-permeable fibers. Highly concentrated MAB is retained in the chamber and is utilized directly from the fiber or processed further depending on the needs of the investigator. Special protein free media is used if the MAB is to be used directly in animals. Antibodies produced by standard tissue culture techniques utilize plastic flasks and standard media. During FY08 8 MABs have been grown, producing nearly 30g of antibody. (DRAFT)