Molecular regulation of GLUT4 targeting

GLUT4靶向的分子调控

• 批准号: nhmrc : 210169
• 负责人: Nia Bryant
• 金额: $ 31.23万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-regulation-glut4-targeting/101522
• 关键词: Molecular; regulation; GLUT4; targeting

Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle and adipose tissue by stimulating the movement of a glucose transport protein from inside the cell to the cell surface (see http:--www.imb.uq.edu.au-groups-james-glut4 for an animated description of this process). The purpose of this proposal is to dissect the molecular mechanisms by which this glucose transporter can be held inside the cell in the absence of insulin and then allowed to be released from this site moving to the surface in the presence of insulin. Our studies over the past 5 years have brought us much closer to understanding this process in detail. The identification of the molecules responsible for this regulatory step will not only aid our understanding of this process but it will also provide a valuable target for development of therapeutic agents that can be used to combat insulin resistance.

胰岛素抵抗（通常对胰岛素敏感的组织，如肌肉和脂肪组织对胰岛素没有反应）导致许多疾病，包括糖尿病和肥胖。这些组织的一个关键代谢步骤是从血液中摄取葡萄糖。胰岛素可以加速这一过程，从而在饭后有效清除血液中的葡萄糖。我们的实验室在表明胰岛素通过刺激葡萄糖转运蛋白从细胞内部到细胞表面的运动来调节葡萄糖进入肌肉和脂肪组织方面发挥了重要作用（参见：- www.imb.uq.edu.au-groups-james-glut4这个过程的动画描述）。这个提议的目的是剖析葡萄糖转运蛋白在没有胰岛素的情况下可以被控制在细胞内，然后在有胰岛素的情况下被允许从这个位置释放到表面的分子机制。我们过去5年的研究使我们更接近于详细了解这一过程。确定负责这一调节步骤的分子不仅有助于我们理解这一过程，而且还将为开发可用于对抗胰岛素抵抗的治疗药物提供有价值的靶标。