Acute HIV infection - A key link for transmission prevention
急性艾滋病毒感染——预防传播的关键环节
基本信息
- 批准号:8094367
- 负责人:
- 金额:$ 96.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAcuteAddressAfrica South of the SaharaAnti-Retroviral AgentsAntigensBehavior TherapyBehavioralBiologicalBloodClinicCommunitiesComplementCounselingCoupledDataDetectionDiagnosisEpidemicEpidemiologyEvaluationEventHIVHIV InfectionsIndividualInfectionInterventionLamivudineLinkMalawiModelingMotivationNetwork-basedParticipantPersonsPharmaceutical PreparationsPhasePilot ProjectsPlayPreventionPrevention programProbabilityRNARandomizedRelative (related person)Research InfrastructureRoleSex BehaviorSexual PartnersSexually Transmitted DiseasesSiteStagingStructureTechnologyTenofovirTestingTimeUnsafe SexViral Load resultVirusWorkantiretroviral therapybasecommunity planningdesigngenital secretionmathematical modelmodels and simulationnew technologynovelnovel strategiespreventprogramsrandomized trialrapid diagnosisskillstransmission process
项目摘要
DESCRIPTION (provided by applicant):
Persons with acute HIV infection (AHI) may be responsible for a substantial proportion of onward transmission of HIV infection, especially in sub-Saharan Africa. AHI, the period between infection and seroconversion, lasts up to 10-12 weeks. During this brief window of time, the virus replicates rapidly, leading to high concentrations of HIV RNA in blood and genital secretions. Consequently, the probability of transmission during unprotected intercourse is very high. Identifying persons with AHI and intervening to reduce onward transmission represents a tantalizing, but unproven, opportunity for HIV prevention. We propose an aggressive HIV transmission prevention program to identify persons with AHI and intervene behaviorally and biologically. Our central hypothesis is that persons with acute HIV infection play an important role in HIV transmission. We further hypothesize that behavioral and treatment interventions in acutely infected persons will reduce onward transmission. To address these hypotheses, we will conduct an exploratory study complemented by mathematical modeling to assess the potential impact of the proposed prevention program. The specific aims of our proposed study are to: 1) Develop a novel program to prevent HIV transmission by identifying and informing persons with acute HIV infection (AHI) in Lilongwe, Malawi, 2) Evaluate a short-term, combined behavioral and antiretroviral therapy (ART) intervention to prevent HIV transmission among persons with AHI, 3) Determine the potential individual and combined impact of each component of the intervention using mathematical modeling. To achieve these aims, we will use our well-established infrastructure in Lilongwe, Malawi. We will take advantage of new and existing technologies to identify people with AHI more rapidly. Immediately after diagnosis, persons will be randomized to standard counseling, an intensive behavioral intervention, or the behavioral intervention combined with short term antiretroviral therapy (ART). The behavioral intervention is based on the Information-Motivation- Behavioral Skills Model. The ART will use new and potent antiretroviral drugs to rapidly block HIV replication and limit infectiousness. Using the data collected in this pilot study, we will use rigorous mathematical modeling to assess the potential impact of the prevention program on the epidemic within a community and plan a large randomized trial. Persons with acute HIV infection (AHI), the earliest stage of HIV infection, may transmit HIV infection at a high rate, especially in sub-Saharan Africa. Given this important possibility, we hypothesize that behavioral and treatment interventions in acutely infected persons will reduce their transmission. To address this hypothesis, we will conduct an exploratory study, coupled with mathematical modeling, to examine the potential impact of combining a behavioral intervention with a course of antiretroviral treatment in persons with AHI.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM C MILLER其他文献
WILLIAM C MILLER的其他文献
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{{ truncateString('WILLIAM C MILLER', 18)}}的其他基金
Syphilis epidemiology in Columbus, Ohio: a cohort and network study
俄亥俄州哥伦布市的梅毒流行病学:队列和网络研究
- 批准号:
9392414 - 财政年份:2017
- 资助金额:
$ 96.22万 - 项目类别:
Reaching Unaware Sexual and Social Contacts to Interrupt Ongoing HIV Transmission
实现不知情的性接触和社会接触以中断持续的艾滋病毒传播
- 批准号:
8790186 - 财政年份:2014
- 资助金额:
$ 96.22万 - 项目类别:
Reaching Unaware Sexual and Social Contacts to Interrupt Ongoing HIV Transmission
实现不知情的性接触和社交接触以中断持续的艾滋病毒传播
- 批准号:
8910633 - 财政年份:2014
- 资助金额:
$ 96.22万 - 项目类别:
Reaching Unaware Sexual and Social Contacts to Interrupt Ongoing HIV Transmission
实现不知情的性接触和社交接触以中断持续的艾滋病毒传播
- 批准号:
9102883 - 财政年份:2014
- 资助金额:
$ 96.22万 - 项目类别:
Reaching Unaware Sexual and Social Contacts to Interrupt Ongoing HIV Transmission
实现不知情的性接触和社会接触以中断持续的艾滋病毒传播
- 批准号:
9323267 - 财政年份:2014
- 资助金额:
$ 96.22万 - 项目类别:
Acute HIV infection - A key link for transmission prevention
急性艾滋病毒感染——预防传播的关键环节
- 批准号:
7680670 - 财政年份:2009
- 资助金额:
$ 96.22万 - 项目类别:
Acute HIV infection - A key link for transmission prevention
急性艾滋病毒感染——预防传播的关键环节
- 批准号:
8318754 - 财政年份:2009
- 资助金额:
$ 96.22万 - 项目类别:
Acute HIV infection - A key link for transmission prevention
急性艾滋病毒感染——预防传播的关键环节
- 批准号:
7898740 - 财政年份:2009
- 资助金额:
$ 96.22万 - 项目类别:
Spatial Epidemiology of Syphilis and Gonorrhea in North Carolina
北卡罗来纳州梅毒和淋病的空间流行病学
- 批准号:
7844825 - 财政年份:2006
- 资助金额:
$ 96.22万 - 项目类别:
Spatial Epidemiology of Syphilis and Gonorrhea in North Carolina
北卡罗来纳州梅毒和淋病的空间流行病学
- 批准号:
7237183 - 财政年份:2006
- 资助金额:
$ 96.22万 - 项目类别:
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