The Connie Wofsy Women's HIV Study

康妮·沃夫西女性艾滋病毒研究

• 批准号: 8093943
• 负责人: RUTH Martha GREENBLATT
• 金额: $ 406.03万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-28 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8093943
• 关键词: Adherence; Age; California; Clinic; Clinical; Collaborations; Communities; Complex; Data; Data Analyses; Data Collection; Endocrinology; Funding; Genetic; Goals; HIV; Hepatology; High Risk Woman; Institution; Instruction; Investigator-Initiated Research; Leadership; Link; Malignant Neoplasms; Menopause; Methods; Participant; Pathogenesis; Pharmacology; Procedures; Protocols documentation; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; San Francisco; Science; Scientist; Site; Source; Specimen Handling; Structure; Training; United States; Universities; Woman; career; career development; cohort; liver biopsy; member; statistics

DESCRIPTION (provided by applicant): This competing renewal application proposes continuation of the Northern California WIHS site (the Connie Wofsy Women's HIV Study - CWWHS), a regional HIV consortium that links community clinics with a leading research institution, the University of California, San Francisco. The CWWHS will contribute several key resources to WIHS: continued high retention rates of a local cohort that is representative of the community of HIV-infected and at-risk women, high rates of adherence to WIHS protocols and data collection completion, data analyses (coordinated with WDMAC) and continued leadership of many WIHS IV scientific initiatives. This WIHS IV application is divided into two main sections as per RFA instructions: the first section reports the contributions of our site to WIHS progress, including cohort and sub-study recruitment and retention, scientific leadership, and contributions to organizational leadership. This section contains several standardized tables and figures (provided by WDMAC) as well as a table summarizing the activities at our site. These WIHS-related activities include those directly funded by the WIHS as well as those supported by other sources. The second section provides our site's specific aims and methods for the research proposed for WIHS IV (proposed in Part A). This includes methods for retention of participants, protocols specific to WIHS IV, data and specimen handling procedures, site structure and ongoing scientific leadership efforts. Investigators at our site continue to make significant contributions to the overall WIHS and with a focus on HIV pathogenesis, pharmacology, hepatology, genetics, malignancies, endocrinology and metabolism, and statistics. The CWWHS staff members are highly trained and productive, as evidenced by our high rates of protocol completion and compliance, low rates of entry error and missing data, and very high rates of participant and staff retention, which we anticipate will continue into WIHS IV. Our site has demonstrated very high rates of recruitment and completion of complex and invasive procedures, such as liver biopsy. As we have done in the past, we expect to expand our collaborations through investigator-initiated research grants. We have established excellent ties with regional and national scientists, many of whom are world-renowned experts in their respective fields, to further WIHS research goals and make an optimal contribution to HIV science. In addition, the CWWHS has leveraged its resources to provide a venue for career development among early career clinical and translational investigators. We are delighted to have this opportunity to propose the continuation of the CWWHS, which we believe can provide unique and important findings on a representative group of HIV-infected and at-risk women in the United States as they transition through menopause, age and evolve in their treatment.

描述（由申请人提供）： 这种竞争性更新申请提出了北加州WIHS网站（Connie Wofsy妇女HIV研究-CWWHS）的延续，该地区是一个将社区诊所与加利福尼亚大学旧金山大学领先的研究机构联系起来的区域HIV财团。 CWWH将为WIHS贡献几个关键资源：当地队列的持续高保留率代表了艾滋病毒感染和处于危险的妇女社区，对WIHS协议的依从性和数据收集完成的高率，数据分析（与WDMAC协调）以及许多WIHSIV IV Scientic Initiativic Initiativic opitiativic opitiative opitiative。根据RFA说明，该WIHS IV应用程序分为两个主要部分：第一部分报告了我们网站对WIHS进度的贡献，包括同伙和子研究招聘和保留，科学领导，科学领导以及对组织领导的贡献。本节包含几个标准化表和数字（由WDMAC提供）以及一个汇总我们网站活动的表。这些与WIHS相关的活动包括由WIHS直接资助的活动以及其他来源支持的活动。第二部分为我们网站提供了针对WIHS IV的研究的具体目的和方法（在A部分中提出）。这包括保留参与者的方法，特定于WIHS IV的协议，数据和标本处理程序，现场结构和持续的科学领导力工作。我们现场的研究人员继续为整个WIH做出重大贡献，并着重于HIV发病机理，药理学，肝病学，遗传学，恶性肿瘤，内分泌学和代谢以及统计学。 CWWHS的工作人员经过了高度培训和富有成效的，这是我们的高协议完成和合规性，入门率低和数据丢失的率以及参与者和员工保留率非常高的率，我们预计这将继续进入IV。我们的网站表现出很高的招聘率以及复杂和侵入性手术的完成，例如肝活检。正如我们过去所做的那样，我们希望通过调查员提出的研究补助金扩大我们的合作。我们已经与区域和国家科学家建立了良好的联系，其中许多人是各自领域的世界知名专家，以进一步发展研究目标，并对艾滋病毒科学做出最佳贡献。此外，CWWH还利用其资源为早期职业临床和转化调查员之间的职业发展提供了一个场所。我们很高兴有机会提出CWWH的延续，我们认为这可以在美国的一群艾滋病毒感染者和处于危险中的妇女中提供独特而重要的发现，因为她们通过更年期，年龄，年龄和待遇发展。