Exploring, Predicting, and Intervening on Long-term Viral suppression Electronically (EPI-LoVE)

电子方式探索、预测和干预长期病毒抑制 (EPI-LoVE)

基本信息

项目摘要

In response to RFA-AI22-024 Limited Interaction Targeted Epidemiology: Viral Suppression (LITE-VS), we propose “Exploring, Predicting, and Intervening on Long-term Viral suppression Electronically (EPI-LoVE)” with a cross-cutting, interdisciplinary scientific team with strong expertise in longitudinal cohorts to enroll a large, digitally maintained cohort of people living with HIV (PLWH) in the US who are not adequately virally suppressed (>200 copies/mL), report prior gaps in HIV care engagement, or lack of sustained viral suppression (VS). The cohort will investigate trajectories of HIV care engagement and VS applying a theoretical approach and analytic strategies that recognize the cyclical nature of retention in HIV care and VS. We will examine the syndemics underlying these outcomes including substance use, mental health, and barriers to HIV care including stigma and rural isolation. Our strategy includes multiple recruitment methods such as a) social media recruitment in partnership with digital advertising companies employing unique tools, websites/apps and artificial intelligence (AI)-based models to optimize outreach/recruitment; and b) a partnership with AIDS Healthcare Foundation (AHF), the largest HIV medical provider in the country. We will enroll a diverse cohort of PLWH enriched with those living in rural areas, Black, under 25 years of age and experiencing substance use challenges. An evidence-based digital platform (HealthMpowerment, HMP) deployed in 10 studies, including other limited interaction targeted epidemiology (LITE) initiatives, will be used for data collection, real-time analysis and participant communication and will be supplemented with semi-annual blood specimens collected with a multi-pronged strategy (i.e. local laboratory, clinics, and home- based collection options) to facilitate participation. We will develop a sophisticated risk assessment tool to optimize when PLWH in our cohort are most at risk for VNS and deliver tailored, real-time intervention components based on their personalized needs at the time they need them most. Our investigative team from three leading institutions The University of California at Los Angeles and Irvine, and University of North Carolina, Chapel Hill has decades of experience with recruitment, engagement, and care of PLHW and large-scale longitudinal cohort studies, as well as long-standing expertise developing digital and AI-based tools in collaboration with HIV stakeholders. We capitalize upon productive partnerships and expertise to articulate the drivers of the ongoing HIV epidemic among the most vulnerable populations in the US and to identify the most effective, expeditious and scalable digital strategies to address this ongoing public health crisis.
针对RFA-AI 22 -024有限相互作用靶向流行病学:病毒抑制 (LITE-VS),我们提出了“探索,预测和干预长期病毒抑制 电子(EPI-LOVE)”与一个跨领域,跨学科的科学团队,具有强大的 纵向队列的专业知识,以招募一个大型的,数字化维护的人群, 在美国,病毒抑制不充分(>200拷贝/mL)的艾滋病毒(PLWH), 艾滋病毒护理参与的差距,或缺乏持续的病毒抑制(VS)。则将队列 调查艾滋病毒护理参与和VS的轨迹应用理论方法, 分析战略,认识到艾滋病毒护理和VS保留的周期性,我们将 检查这些结果的基础症状,包括物质使用,心理健康, 艾滋病毒护理的障碍,包括耻辱和农村隔离。我们的战略包括多个招聘 a)与数字广告公司合作进行社交媒体招聘 采用独特的工具、网站/应用程序和基于人工智能(AI)的模型来优化 外展/招募;以及B)与艾滋病保健基金会(AHF)建立伙伴关系, 艾滋病医疗服务提供者。我们将招募一个多样化的PLWH队列, 生活在农村地区,黑人,25岁以下,面临药物使用的挑战。 在10项研究中部署了一个基于证据的数字平台(健康赋权,HMP),包括 其他有限互动目标流行病学(LITE)倡议,将用于数据收集, 实时分析和参与者沟通,并将补充每半年一次的 采用多管齐下的策略(即当地实验室、诊所和家庭)采集血液样本, 收集选项),以促进参与。我们将开发一个复杂的风险 评估工具,以优化我们队列中PLWH最有可能发生VNS的时间, 定制的,实时干预组件,根据他们的个性化需求, 最需要他们。我们的调查团队来自三个领先的机构加州大学 在洛杉矶和欧文,以及北卡罗来纳州的大学,查佩尔山有几十年的 PLHW和大规模纵向队列的招募、参与和护理经验 研究,以及合作开发数字和基于人工智能的工具的长期专业知识 与艾滋病毒利益相关者。我们利用富有成效的伙伴关系和专业知识, 艾滋病毒在美国最脆弱人群中持续流行的驱动因素, 确定最有效、最迅速和最可扩展的数字战略,以解决这一持续的问题。 公共卫生危机。

项目成果

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Pamina Mae Gorbach其他文献

Pamina Mae Gorbach的其他文献

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{{ truncateString('Pamina Mae Gorbach', 18)}}的其他基金

SWG 1 -Translational Research on Substance Use SWG
SWG 1 - 物质使用转化研究 SWG
  • 批准号:
    10609769
  • 财政年份:
    2022
  • 资助金额:
    $ 168.46万
  • 项目类别:
SWG 1 -Translational Research on Substance Use SWG
SWG 1 - 物质使用转化研究 SWG
  • 批准号:
    10458376
  • 财政年份:
    2022
  • 资助金额:
    $ 168.46万
  • 项目类别:
Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)
产生 NIDA 机会的群体合作联盟 (C3PNO)
  • 批准号:
    10552117
  • 财政年份:
    2017
  • 资助金额:
    $ 168.46万
  • 项目类别:
Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)
产生 NIDA 机会的群体合作联盟 (C3PNO)
  • 批准号:
    10165380
  • 财政年份:
    2017
  • 资助金额:
    $ 168.46万
  • 项目类别:
Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)
产生 NIDA 机会的群体合作联盟 (C3PNO)
  • 批准号:
    10352063
  • 财政年份:
    2017
  • 资助金额:
    $ 168.46万
  • 项目类别:
Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) Second Bridge Funding Supplement
产生 NIDA 机会的队列合作联盟 (C3PNO) 第二桥资金补充
  • 批准号:
    10609365
  • 财政年份:
    2017
  • 资助金额:
    $ 168.46万
  • 项目类别:
UCLA/Cambodia HIV/AIDS Training Program in Data Management & Analysis
加州大学洛杉矶分校/柬埔寨艾滋病毒/艾滋病数据管理培训计划
  • 批准号:
    8710821
  • 财政年份:
    2014
  • 资助金额:
    $ 168.46万
  • 项目类别:
UCLA/Cambodia HIV/AIDS Training Program in Data Management & Analysis
加州大学洛杉矶分校/柬埔寨艾滋病毒/艾滋病数据管理培训计划
  • 批准号:
    8853361
  • 财政年份:
    2014
  • 资助金额:
    $ 168.46万
  • 项目类别:
UCLA/Cambodia HIV/AIDS Training Program in Data Management & Analysis
加州大学洛杉矶分校/柬埔寨艾滋病毒/艾滋病数据管理培训计划
  • 批准号:
    9050715
  • 财政年份:
    2014
  • 资助金额:
    $ 168.46万
  • 项目类别:
MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)
加州大学洛杉矶分校的 MSM 和物质队列将感染注意影响联系起来(男性)
  • 批准号:
    8850993
  • 财政年份:
    2013
  • 资助金额:
    $ 168.46万
  • 项目类别:

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药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
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  • 批准号:
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Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
  • 批准号:
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针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
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Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
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Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
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