Prospective Evaluation of Acute Kidney Injury (PEAK) Cohort

急性肾损伤 (PEAK) 队列的前瞻性评估

• 批准号: 7985255
• 负责人: Alan S Go
• 金额: $ 10万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7985255
• 关键词: Acceleration; Accounting; Acute; Acute Renal Failure with Renal Papillary Necrosis; American; Ancillary Study; Biological; Biological Markers; Blood; California; Cardiovascular system; Cessation of life; Chronic Kidney Failure; Clinical; Clinical Research; Collaborations; Collection; Communities; Cost Effectiveness Analysis; Data; Development; Dialysis procedure; End stage renal failure; Epidemiologic Studies; Epidemiology; Evaluation; Event; Filtration; Follow-Up Studies; Future; Gelatinase A; Hospitalization; Hospitals; Incidence; Interleukin-18; Kidney; Knowledge; Liver; Morbidity - disease rate; Natural History; Nephrology; Outcome; Participant; Patients; Persons; Public Health; Publishing; Recording of previous events; Recurrence; Renal function; Reporting; Research; Research Infrastructure; Research Personnel; Research Priority; Risk; Risk Assessment; Sampling; San Francisco; Serum; Societies; Time; Universities; Urine; adverse outcome; base; cohort; experience; fatty acid-binding proteins; high risk; indexing; mortality; novel; post gamma-globulins; programs; prospective; rat KIM-1 protein; repository; response; tool; urinary

DESCRIPTION (provided by applicant): Acute kidney injury (AKI) refers to a sudden, unexpected decrease in kidney function, and dialysis-requiring AKI is associated with a high risk of short-term death. Its clinical and public health importance is underscored by recent studies showing a rising incidence over time. Previous studies AKI have primarily focused only on outcomes during the AKI hospitalization, with little known about long-term outcomes, including risk of development and acceleration of chronic kidney disease, death and recurrent AKI. In response to RFA-DK- 07-009 "Ancillary Studies in the Natural History of Acute Kidney Injury," we propose to establish a Clinical Center as part of the Acute Kidney Injury Natural History Consortium. We will contribute 200 case subjects who suffered AKI and 200 matched controls. Our application is an ancillary study to ongoing NIDDK-sponsored clinical studies of AKI at Kaiser Permanente of Northern California and UCSF (R01 DK67126). Our four Specific Aims are: Aim 1: To sequentially determine the trajectory of kidney function for up to 4 years among patients who suffer acute kidney injury compared with appropriately matched controls. Aim 2: To assess the risks of death, cardiovascular events and other outcomes for up to 4 years between patients who suffer acute kidney injury compared with appropriately matched controls. Aim 3: To identify and/or validate biomarkers or other risk assessment tools for patients who will develop or have worsening chronic kidney disease, or other significant long-term morbidity or mortality after an episode of acute kidney injury. Aim 4: To contribute to a new central repository to preserve the data and biological samples to share with the scientific community for future analyses and/or biomarker studies in acute kidney injury. The particular strengths of this proposal include a very experienced research team with expertise in acute and chronic kidney disease epidemiology, a strong history of successful participant recruitment and retention into long-term follow-up studies, and a unique infrastructure at Kaiser Permanente of Northern California which provide critical information about kidney function trajectory before an episode of acute kidney injury.

描述(由申请人提供)： 急性肾损伤(AKI)指的是肾功能突然、意外的下降，而需要透析的AKI与短期死亡的高风险相关。最近的研究表明，随着时间的推移，发病率不断上升，突显了其临床和公共卫生的重要性。以前的研究主要集中在AKI住院期间的结果，对长期结果知之甚少，包括发展和加速慢性肾脏疾病、死亡和复发AKI的风险。为响应RFA-DK-07-009《急性肾损伤自然史的辅助研究》，我们建议建立一个临床中心，作为急性肾损伤自然史联合会的一部分。我们将捐献200名急性心肌梗死患者和200名匹配的对照组。我们的申请是NIDDK赞助的北加州Kaiser Permanente和加州大学旧金山分校正在进行的AKI临床研究的辅助研究(R01 DK67126)。我们的四个具体目标是：目标1：与适当匹配的对照组相比，连续测定急性肾损伤患者长达4年的肾功能轨迹。目的2：与适当配对的对照组相比，评估急性肾损伤患者之间长达4年的死亡、心血管事件和其他结局的风险。目的3：识别和/或验证生物标志物或其他风险评估工具，用于急性肾损伤后将发展或恶化的慢性肾脏疾病或其他重大长期发病率或死亡率的患者。目的4：为建立一个新的中央资料库作出贡献，以保存数据和生物样本，以便与科学界共享，用于未来急性肾损伤的分析和/或生物标记物研究。这项建议的特别优势包括一支在急性和慢性肾脏疾病流行病学方面具有专业知识的非常有经验的研究团队，成功招募和留住参与者进行长期跟踪研究的强大历史，以及北加州Kaiser Permanente的独特基础设施，该基础设施可在急性肾脏损伤发生之前提供有关肾功能轨迹的关键信息。