HMO Research Network Cardiovascular Research Network

描述(由申请人提供)： 尽管心血管疾病(CVD)的诊断和治疗在过去几十年中取得了许多进展，但它仍然是美国死亡和残疾的主要原因，也是全球发病率和死亡率上升最快的原因之一。这突显了确定关于心血管疾病流行病学、心血管疾病治疗的使用和后果以及纵向结果的当代和强有力的数据的重要性。HMO研究网络是由15个非营利性健康计划组成的联盟 在美国各地分布着综合研究部门，致力于公共领域的研究，通过其1100万健康计划成员的工作来促进人口健康。这个以社区为基础的网络提供了一个独特的机会来填补国家心肺血液研究所在RFA-HL-07-011中确定的与心血管疾病相关的关键知识空白，“社区护理中的心血管研究网络(CVRN)”。 因此，我们建议的整体目标是： 目的1.在HMO研究网络的14个成员计划之间建立一个合作的心血管研究网络(CVRN)，以创建一个独特的全国性资源，利用该网络的心血管专业知识、多样化的社区研究人群和丰富的电子数据系统。 目的2.利用HMO研究网络CVRN进行三个核心研究项目，证明该网络有能力提供对心血管疾病趋势、风险因素和结果的洞察；识别预后因素；以及评估和改进心血管疾病的管理和相关的临床结果。核心研究项目将着眼于高血压控制、华法林治疗房颤和静脉血栓栓塞症的护理质量和结果，以及植入型心脏复律除颤器的使用和结果。 目的3.在医疗卫生组织研究网络CVRN内实施有效的模式结构，以快速响应新出现的心血管研究问题，并促进富有成效的外部合作，使CVRN的价值和生产力最大化。 A部分：总体计划评审

DESCRIPTION (provided by applicant): Despite many advances in the diagnosis and treatment of cardiovascular disease (CVD) over the past several decades, it remains the leading cause of death and disability in the US and is one of the fastest rising causes of morbidity and mortality globally. This highlights the importance of ascertainment of contemporary and robust data on CVD epidemiology, use and consequences of CVD therapies, and longitudinal outcomes. The HMO Research Network is a consortium of 15 not-for-profit health plans geographically distributed throughout the U.S. with integrated research divisions committed to public domain research that advances population health through its work among its >11 million health plan members. This community-based network provides a unique opportunity to fill key knowledge gaps related to CVD identified by the National Heart, Lung and Blood Institute in RFA-HL-07-011, "Cardiovascular Research Network (CVRN) in Community-Based Care." Therefore, the overall aims of our proposal are to: Aim 1. To establish a collaborative Cardiovascular Research Network (CVRN) among 14 member plans of the HMO Research Network to create a unique national resource that leverages the network's cardiovascular expertise, diverse community-based study populations, and rich electronic data systems. Aim 2. To leverage the HMO Research Network CVRN to conduct three core research projects that demonstrate the network's capability to provide insights into trends in cardiovascular disease, risk factors, and outcomes; identification of prognostic factors; and evaluation and improvement of management and associated clinical outcomes of cardiovascular conditions. The core research projects will target hypertension control, quality of care and outcomes of warfarin therapy for atrial fibrillation and venous thromboembolism, and the use and outcomes of implantable cardioverter defibrillators. Aim 3. To implement an effective model structure within the HMO Research Network CVRN to rapidly respond to emerging cardiovascular research questions and to facilitate productive external collaborations that maximize the value and productivity of the CVRN. Section A: Overall Program Review