PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study

太平洋岛民、夏威夷原住民和亚裔美国人心血管健康流行病学 (PANACHE) 研究

• 批准号: 10632951
• 负责人: Alan S Go
• 金额: $ 69.88万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-04 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632951
• 关键词: Accident and Emergency department; Acute myocardial infarction; Address; Adult; Artificial Intelligence; Asian Americans; Asian population; Atherosclerosis; Atrial Fibrillation; Behavioral; Blood; Blood specimen; California; Cardiovascular Diseases; Cardiovascular system; Caring; Chinese; Clinical; Collaborations; Collection; Data; Data Analytics; Data Reporting; Data Sources; Diabetes Mellitus; Dietary Factors; Dyslipidemias; East Asian; Electronic Health Record; Environmental Exposure; Environmental Risk Factor; Epidemiology; Ethnic Population; Filipino; Goals; Hawaii; Heart failure; Heterogeneity; Incidence; Inpatients; Integrated Delivery of Health Care; Interdisciplinary Study; Knowledge; Life Style; Link; Machine Learning; Methods; Myocardial Infarction; Native Hawaiian or Other Pacific Islander; Not Hispanic or Latino; Obesity; Outcome; Outpatients; Patient Self-Report; Patients; Pattern; Pharmaceutical Preparations; Population; Population Group; Predictive Analytics; Public Health; Quality of Care; Reporting; Risk; Risk Factors; Sample Size; South Asian; Specimen; Subgroup; System; Variant; advanced analytics; biobank; blood pressure elevation; cardiometabolic risk; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; clinical risk; computer infrastructure; demographics; epidemiology study; ethnic difference; experience; improved; insight; member; multidisciplinary; novel; patient subsets; personalized care; predictive modeling; prospective; recruit; risk prediction; risk prediction model; social culture; sociocultural determinant; sociodemographics; southeast Asian; success

ABSTRACT In 2020, there were nearly 24 million Asian Americans and 1.6 million Native Hawaiians and other Pacific Islanders in the U.S., representing 8% of the total U.S. population, and these groups represent the fastest growing U.S. population group over the past decade. Yet, few data exist about the contemporary epidemiology of major cardiovascular diseases and explanatory variables between different Asian American, Native Hawaiian and Pacific Islander (AANHPI) subgroups in large, representative U.S. populations and compared with non-Hispanic Whites. As highlighted in NOT-HL-23-001 (Epidemiologic studies in Asian Americans, Native Hawaiians, and Pacific Islanders), there is a pressing need to fill these key knowledge gaps given the substantial heterogeneity between these different subpopulations in a variety of exposures that may potentially contribute to differential rates of cardiovascular diseases and reflect opportunities to improve care and outcomes. We propose to address many of these knowledge gaps through the PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study which will leverage collaborations between the Kaiser Permanente Northern California and Kaiser Permanente Hawaii integrated healthcare delivery systems whose collective AANHPI adult population is >800,000 and non-Hispanic white population of >1.7 million between 2012 and 2021. The specific aims of the PANACHE Study are (1) to delineate the contemporary incidences of heart failure (HF), atrial fibrillation (AF) and myocardial infarction (MI) among different AANHPI subpopulations compared with non-Hispanic Whites; (2) to develop and validate novel predictive models for incident HF, AF and MI within AANHPI subpopulations; and (3) to characterize self- reported sociocultural, behavioral, dietary and environmental factors across AANHPI subpopulations and their association with clinical cardiovascular risk factors and overall predicted risks of incident HF, AF and MI, along with establishing a linked data and specimen biorepository using remote blood collection methods. Overall, the PANACHE Study brings together a highly experienced multidisciplinary team with complimentary expertise in cardiovascular disease and evaluating ethnic differences, use of electronic health records and other data sources, and advanced predictive analytics; as well as access to and success in engaging large populations of AANHPI adults in Hawaii and Northern California. The PANACHE Study will increase our understanding of the epidemiology and contributing factors to major cardiovascular diseases in support of the goal to improve the quality of care and outcomes for these understudied patient subgroups.

摘要 2020年，有近2400万亚裔美国人和160万夏威夷原住民和其他太平洋 美国的岛民，占美国总人口的8%，这些群体代表了最快的 在过去的十年里，美国人口不断增长。然而，关于当代流行病学的数据很少 主要心血管疾病和解释变量之间的不同亚裔美国人， 夏威夷人和太平洋岛民（AANHPI）亚组在大型，有代表性的美国人群中进行比较 非西班牙裔白人。如NOT-HL-23-001（亚裔美国人流行病学研究，原住民 夏威夷人和太平洋岛民），迫切需要填补这些关键的知识空白， 这些不同亚群之间在各种暴露中存在显著异质性， 有助于心血管疾病发病率的差异，并反映出改善护理的机会， 结果。我们建议通过太平洋岛民、土著人和土著人教育， 夏威夷和亚裔美国人心血管健康流行病学（PANACHE）研究将利用 Kaiser Permanente北方加州和Kaiser Permanente夏威夷之间的合作整合了 AANHPI成年人口总数> 800，000和非西班牙裔白色人的医疗保健提供系统 2012年至2021年人口超过170万。PANACHE研究的具体目标是：（1） 描述心力衰竭（HF）、房颤（AF）和心肌梗死（MI）的当代发生率 在不同的AANHPI亚群与非西班牙裔白人相比;（2）开发和验证 AANHPI亚群中新发HF、AF和MI的新预测模型;（3）描述自身 报告了AANHPI亚群的社会文化、行为、饮食和环境因素及其 与临床心血管风险因素和HF、AF和MI事件的总体预测风险相关，沿着 使用远程血液采集方法建立数据和样本生物储存库。总体看 PANACHE研究汇集了一个经验丰富的多学科团队，具有免费的专业知识， 心血管疾病和评估种族差异，使用电子健康记录和其他数据 资源和先进的预测分析;以及访问和成功地吸引大量的 夏威夷和北方加州的AANHPI成年人。PANACHE研究将增加我们对 流行病学和主要心血管疾病的成因，以支持改善 这些未充分研究的患者亚组的护理质量和结局。