PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study

太平洋岛民、夏威夷原住民和亚裔美国人心血管健康流行病学 (PANACHE) 研究

• 批准号: 10632951
• 负责人: Alan S Go
• 金额: $ 69.88万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-04 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632951
• 关键词: Accident and Emergency department; Acute myocardial infarction; Address; Adult; Artificial Intelligence; Asian Americans; Asian population; Atherosclerosis; Atrial Fibrillation; Behavioral; Blood; Blood specimen; California; Cardiovascular Diseases; Cardiovascular system; Caring; Chinese; Clinical; Collaborations; Collection; Data; Data Analytics; Data Reporting; Data Sources; Diabetes Mellitus; Dietary Factors; Dyslipidemias; East Asian; Electronic Health Record; Environmental Exposure; Environmental Risk Factor; Epidemiology; Ethnic Population; Filipino; Goals; Hawaii; Heart failure; Heterogeneity; Incidence; Inpatients; Integrated Delivery of Health Care; Interdisciplinary Study; Knowledge; Life Style; Link; Machine Learning; Methods; Myocardial Infarction; Native Hawaiian or Other Pacific Islander; Not Hispanic or Latino; Obesity; Outcome; Outpatients; Patient Self-Report; Patients; Pattern; Pharmaceutical Preparations; Population; Population Group; Predictive Analytics; Public Health; Quality of Care; Reporting; Risk; Risk Factors; Sample Size; South Asian; Specimen; Subgroup; System; Variant; advanced analytics; biobank; blood pressure elevation; cardiometabolic risk; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; clinical risk; computer infrastructure; demographics; epidemiology study; ethnic difference; experience; improved; insight; member; multidisciplinary; novel; patient subsets; personalized care; predictive modeling; prospective; recruit; risk prediction; risk prediction model; social culture; sociocultural determinant; sociodemographics; southeast Asian; success

ABSTRACT In 2020, there were nearly 24 million Asian Americans and 1.6 million Native Hawaiians and other Pacific Islanders in the U.S., representing 8% of the total U.S. population, and these groups represent the fastest growing U.S. population group over the past decade. Yet, few data exist about the contemporary epidemiology of major cardiovascular diseases and explanatory variables between different Asian American, Native Hawaiian and Pacific Islander (AANHPI) subgroups in large, representative U.S. populations and compared with non-Hispanic Whites. As highlighted in NOT-HL-23-001 (Epidemiologic studies in Asian Americans, Native Hawaiians, and Pacific Islanders), there is a pressing need to fill these key knowledge gaps given the substantial heterogeneity between these different subpopulations in a variety of exposures that may potentially contribute to differential rates of cardiovascular diseases and reflect opportunities to improve care and outcomes. We propose to address many of these knowledge gaps through the PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study which will leverage collaborations between the Kaiser Permanente Northern California and Kaiser Permanente Hawaii integrated healthcare delivery systems whose collective AANHPI adult population is >800,000 and non-Hispanic white population of >1.7 million between 2012 and 2021. The specific aims of the PANACHE Study are (1) to delineate the contemporary incidences of heart failure (HF), atrial fibrillation (AF) and myocardial infarction (MI) among different AANHPI subpopulations compared with non-Hispanic Whites; (2) to develop and validate novel predictive models for incident HF, AF and MI within AANHPI subpopulations; and (3) to characterize self- reported sociocultural, behavioral, dietary and environmental factors across AANHPI subpopulations and their association with clinical cardiovascular risk factors and overall predicted risks of incident HF, AF and MI, along with establishing a linked data and specimen biorepository using remote blood collection methods. Overall, the PANACHE Study brings together a highly experienced multidisciplinary team with complimentary expertise in cardiovascular disease and evaluating ethnic differences, use of electronic health records and other data sources, and advanced predictive analytics; as well as access to and success in engaging large populations of AANHPI adults in Hawaii and Northern California. The PANACHE Study will increase our understanding of the epidemiology and contributing factors to major cardiovascular diseases in support of the goal to improve the quality of care and outcomes for these understudied patient subgroups.

抽象的 2020 年，有近 2400 万亚裔美国人和 160 万夏威夷原住民和其他太平洋人 美国岛民占美国总人口的8%，这些群体代表了最快的 过去十年美国人口不断增长。然而，关于当代流行病学的数据却很少 不同亚裔美国人、原住民之间的主要心血管疾病和解释变量 夏威夷和太平洋岛民 (AANHPI) 亚群在大量具有代表性的美国人口中进行比较 与非西班牙裔白人。正如 NOT-HL-23-001（亚裔美国人的流行病学研究、原住民 夏威夷人和太平洋岛民），鉴于 这些不同亚群之间在各种暴露中存在显着的异质性，这可能会导致 有助于心血管疾病的不同发病率，并反映出改善护理和治疗的机会 结果。我们建议通过太平洋岛民、原住民解决许多这些知识差距 夏威夷和亚裔美国人心血管健康流行病学 (PANACHE) 研究将利用 北加州 Kaiser Permanente 和夏威夷 Kaiser Permanente 之间的合作整合 AANHPI 成年人口和非西班牙裔白人总数超过 800,000 的医疗保健提供系统 2012 年至 2021 年间人口超过 170 万。 PANACHE 研究的具体目标是 (1) 描述当代心力衰竭 (HF)、心房颤动 (AF) 和心肌梗塞 (MI) 的发病率 不同 AANHPI 亚群与非西班牙裔白人之间的比较； (2) 开发和验证 AANHPI 亚群中发生 HF、AF 和 MI 的新型预测模型； (3) 表征自我 报告了 AANHPI 亚人群及其群体的社会文化、行为、饮食和环境因素 与临床心血管危险因素以及 HF、AF 和 MI 事件总体预测风险的关联，以及 使用远程血液采集方法建立链接的数据和样本生物存储库。总体而言， PANACHE 研究汇集了一支经验丰富的多学科团队，他们在以下领域具有互补的专业知识 心血管疾病和评估种族差异、电子健康记录和其他数据的使用 来源和高级预测分析；以及接触并成功吸引大量人群 夏威夷和北加州的 AANHPI 成人。 PANACHE 研究将增加我们对 流行病学和主要心血管疾病的影响因素，以支持改善心血管疾病的目标 这些未充分研究的患者亚组的护理质量和结果。