PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study

摘要 2020年，有近2400万亚裔美国人和160万夏威夷原住民和其他太平洋人 美国的岛民，占美国总人口的8%，这些群体代表着最快的 在过去的十年里，美国人口群体不断增长。然而，关于当代流行病学的数据却很少。 主要心血管疾病和解释变量在不同亚裔美国人之间的差异 夏威夷人和太平洋岛民(AANHPI)亚群在具有代表性的美国人口中的比较 和非西班牙裔白人。正如NOT-HL-23-001(亚裔美国人流行病学研究，原住民 夏威夷人和太平洋岛民)，迫切需要填补这些关键知识空白，因为 这些不同亚群之间在各种暴露中的显著异质性可能 有助于心血管疾病的不同发病率，并反映改善护理和 结果。我们建议通过太平洋岛民，原住民来解决这些知识差距 夏威夷人和亚裔美国人心血管健康流行病学(PANACH)研究将利用 北加州凯撒永久酒店和夏威夷凯撒永久酒店之间的合作整合 AANHPI成人人口总数为80万人且非西班牙裔白人的医疗保健服务体系 2012至2021年间，中国人口为170万。PANAChE研究的具体目的是(1) 描述心力衰竭(HF)、房颤(AF)和心肌梗死(MI)的当代发病率 在不同的AANHPI亚群中与非西班牙裔白人进行比较；(2)建立和验证 AANHPI亚群内入射HF、AF和MI的新预测模型；以及(3)表征自身 报道了AANHPI亚群及其成员的社会文化、行为、饮食和环境因素 与临床心血管危险因素和发生心力衰竭、房颤和心肌梗死总体预测风险的相关性 通过使用远程血液采集方法建立关联数据和标本生物库。总体而言， Panache Study汇集了一支经验丰富的多学科团队，他们在 心血管疾病和评估种族差异、电子健康记录和其他数据的使用 来源和高级预测分析；以及接触和成功接触大量人口 AANHPI夏威夷和加利福尼亚州北部的成年人。PANAChE研究将增加我们对 主要心血管疾病的流行病学和致病因素，以支持改善 这些研究不足的患者亚组的护理质量和结果。

ABSTRACT In 2020, there were nearly 24 million Asian Americans and 1.6 million Native Hawaiians and other Pacific Islanders in the U.S., representing 8% of the total U.S. population, and these groups represent the fastest growing U.S. population group over the past decade. Yet, few data exist about the contemporary epidemiology of major cardiovascular diseases and explanatory variables between different Asian American, Native Hawaiian and Pacific Islander (AANHPI) subgroups in large, representative U.S. populations and compared with non-Hispanic Whites. As highlighted in NOT-HL-23-001 (Epidemiologic studies in Asian Americans, Native Hawaiians, and Pacific Islanders), there is a pressing need to fill these key knowledge gaps given the substantial heterogeneity between these different subpopulations in a variety of exposures that may potentially contribute to differential rates of cardiovascular diseases and reflect opportunities to improve care and outcomes. We propose to address many of these knowledge gaps through the PAcific Islander, Native Hawaiian and Asian American Cardiovascular Health Epidemiology (PANACHE) Study which will leverage collaborations between the Kaiser Permanente Northern California and Kaiser Permanente Hawaii integrated healthcare delivery systems whose collective AANHPI adult population is >800,000 and non-Hispanic white population of >1.7 million between 2012 and 2021. The specific aims of the PANACHE Study are (1) to delineate the contemporary incidences of heart failure (HF), atrial fibrillation (AF) and myocardial infarction (MI) among different AANHPI subpopulations compared with non-Hispanic Whites; (2) to develop and validate novel predictive models for incident HF, AF and MI within AANHPI subpopulations; and (3) to characterize self- reported sociocultural, behavioral, dietary and environmental factors across AANHPI subpopulations and their association with clinical cardiovascular risk factors and overall predicted risks of incident HF, AF and MI, along with establishing a linked data and specimen biorepository using remote blood collection methods. Overall, the PANACHE Study brings together a highly experienced multidisciplinary team with complimentary expertise in cardiovascular disease and evaluating ethnic differences, use of electronic health records and other data sources, and advanced predictive analytics; as well as access to and success in engaging large populations of AANHPI adults in Hawaii and Northern California. The PANACHE Study will increase our understanding of the epidemiology and contributing factors to major cardiovascular diseases in support of the goal to improve the quality of care and outcomes for these understudied patient subgroups.