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DESCRIPTION (provided by applicant): We have seen the emergence of a generation of medical terminologies satisfying systematic inheritance of relationships. Examples include SNOMED CT (the Systematized Nomenclature of Medicine - Clinical Terms), the National Cancer Institute Thesaurus (NCIT), Kaiser's Convergent Medical Terminology (CMT), the VA's internal enterprise terminology, the Foundational Model of Anatomy (FMA), and the Medical Entities Dictionary (MED). These terminologies are of substantial size and complexity. Due to this, user orientation is difficult, especially given the fact that more knowledge is continually being added to them. Orientation and navigation capabilities are essential for effective terminology maintenance and usage (for example, in decision-support systems, patient records, and healthcare administrative systems). One cannot reasonably be expected to maintain or use a terminology reliably without them. We propose to design structural abstraction methodologies to derive novel terminological views called "taxonomies." These will form the bases for new techniques to support user orientation to and navigation of terminologies. The taxonomies will further aid in efficient auditing. A number of different levels of taxonomy will be developed. Our methodologies will utilize the IS-A relationship hierarchies and accompanying systematic relationship inheritance of this generation of terminologies. They will be based on new partitioning techniques, which will break down large collections of concepts into smaller units of structurally and semantically similar concepts that can be more easily handled and comprehended. One partitioning technique will be based on similar relationship structure, leading to the derivation of an abstraction network call the "area taxonomy." Another will further utilize semantic similarity based on common ancestry in the terminology's ISA hierarchy leading to the finer-grained "p-area taxonomy." Additional partitioning techniques---leading to further refined taxonomies---will focus on other structural features of terminologies, such as obtainment-pattern regions. Our abstraction methodologies will be general and applicable to a wide range of terminologies satisfying systematic inheritance. We will use SNOMED and the NCIT's genomics hierarchies as test-beds. We will demonstrate the utility of our taxonomy-based methodologies by defining various complexity measures with respect to the underlying terminology networks and by tracking terminology evolution.
期刊论文(11)
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Auditing complex concepts in overlapping subsets of SNOMED.
审核 SNOMED 重叠子集中的复杂概念。
DOI: --
发表时间: 2008
期刊: AMIA ... Annual Symposium proceedings. AMIA Symposium
影响因子: --
作者: [Wang,Yue, Wei,Duo, Xu,Junchuan, Elhanan,Gai, Perl,Yehoshua, Halper,Michael, Chen,Yan, Spackman,KentA, Hripcsak,George]
通讯作者: Hripcsak,George
DOI: 10.1016/j.jbi.2011.08.013
发表时间: 2012-02
期刊: JOURNAL OF BIOMEDICAL INFORMATICS
影响因子: 4.5
作者: [Wang, Yue, Halper, Michael, Wei, Duo, Perl, Yehoshua, Geller, James]
通讯作者: Geller, James
Auditing SNOMED relationships using a converse abstraction network.
使用逆向抽象网络审核 SNOMED 关系。
DOI: --
发表时间: 2009
期刊: AMIA ... Annual Symposium proceedings. AMIA Symposium
影响因子: --
作者: [Wei,Duo, Halper,Michael, Elhanan,Gai, Chen,Yan, Perl,Yehoshua, Geller,James, Spackman,KentA]
通讯作者: Spackman,KentA
Complexity measures to track the evolution of a SNOMED hierarchy.
用于跟踪 SNOMED 层次结构演变的复杂性度量。
DOI: --
发表时间: 2008
期刊: AMIA ... Annual Symposium proceedings. AMIA Symposium
影响因子: --
作者: [Wei,Duo, Wang,Yue, Perl,Yehoshua, Xu,Junchuan, Halper,Michael, Spackman,KentA, Spackman,Kent]
通讯作者: Spackman,Kent
8
    A family-based framework of quality assurance for biomedical ontologies
    A family-based framework of quality assurance for biomedical ontologies
    Taxonomies Supporting Orientation, Navigation and Auditing of Terminologies
    Taxonomies Supporting Orientation, Navigation and Auditing of Terminologies
    国内基金
    海外基金
    层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
    • 批准号:
      2021JJ40433
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2021
    • 负责人:
      孙磊
    • 依托单位:
    寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
    • 批准号:
      32001603
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      24.0万元
    • 批准年份:
      2020
    • 负责人:
      段真珍
    • 依托单位:
    AREA国际经济模型的移植.改进和应用
    • 批准号:
      18870435
    • 项目类别:
      面上项目
    • 资助金额:
      2.0万元
    • 批准年份:
      1988
    • 负责人:
      史树中
    • 依托单位: