Clinical Bone Mechanics Using HR-pQCT and ??MRI

使用 HR-pQCT 和 MRI 进行临床骨力学

• 批准号: 8089447
• 负责人: X. Edward GUO
• 金额: $ 65.73万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089447
• 关键词: 3-Dimensional; Address; Age; Biomechanics; Bone Density; Bone Tissue; Clinical; Competence; Data; Development; Distal; Effectiveness; Elements; Failure; Fracture; Gold; Image; Individual; Ionizing radiation; Laboratories; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Metabolic Bone Diseases; Methods; Modality; Modeling; Noise; Osteoporosis; Patients; Peripheral; Property; Radial; Recording of previous events; Research; Research Personnel; Resolution; Risk; Risk Factors; Scanning; Signal Transduction; Site; Skeleton; Spinal Fractures; Techniques; Technology; Testing; Thick; Time; Woman; X-Ray Computed Tomography; base; bone; bone geometry; bone health; bone imaging; bone strength; clinically relevant; dual diagnosis; high standard; imaging modality; in vivo; lumbar vertebra bone structure; mineralization; novel; osteoporosis with pathological fracture; peer; public health relevance; skeletal; spine bone structure; substantia spongiosa; tibia; tool; vertebra body

DESCRIPTION (provided by applicant): Recent advances in high-resolution imaging have permitted the development of new tools, notably micro- magnetic resonance (5MR) imaging and high-resolution peripheral quantitative computed tomography (HR- pQCT), that promise to provide a better profile of overall bone strength beyond areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA). In this application, we seek to determine whether image- based microstructural and 5FE analyses can distinguish between individuals who have vertebral fractures from their counterparts without vertebral fractures. In the proposed project we advance the following hypotheses: 1. Morphological measurements and 5FE predictions of stiffness and failure load of the distal tibia and radius from ex vivo 5MRI and HR-pQCT correlate highly with those from 5CT and direct mechanical testing, and, furthermore, that parameters from the two peripheral sites parallel those in the vertebrae. 2. 5FE-derived estimates of elastic stiffness and failure load from in vivo 5MR and HR-pQCT images can differentiate between individuals with vertebral fractures from those without vertebral fractures better than microstructural measures derived by the two imaging modalities alone or aBMD by DXA. We plan to address the above hypotheses with the following specific aims: Specific Aim 1a: Perform 5MRI and HR-pQCT scans of the distal tibia and radius ex vivo under signal-to-noise and resolution conditions achievable in vivo, and compare trabecular and cortical bone microstructural measurements obtained in this manner with those from high-resolution 5CT. Specific Aim 1b: Compare the stiffness and failure load of whole bone segments of the distal tibia and radius as predicted by HR-pQCT and 5MR image-based nonlinear 5FE analyses to those predicted by 5CT image- based 5FE analysis and direct mechanical testing. Specific Aim 2a: Perform 5CT scans of lumbar vertebrae from the same subjects as the distal tibia and radius used in Aims 1a and 1b Specific Aim 2b: Compare trabecular and cortical bone microstructural measurements and 5FE predictions based on the imaging data obtained by HR-pQCT and 5MRI in Aims 1a and 1b with the 5CT measurements and direct mechanical testing of the corresponding vertebrae in Aim 2a. Specific Aim 3a: Apply the microstructural and 5FE techniques validated in Aims 1 and 2 to in vivo 5MRI and HR-pQCT scans from healthy women and compare these measurements between the two imaging modalities. Specific Aim 3b: Apply the microstructural and 5FE techniques validated in Aims 1 and 2 to the two peripheral imaging modalities and determine the effectiveness of methods in distinguishing between vertebral fracture subjects and their non-fractured peers using data from two imaging studies previously performed or currently in progress in the investigators' laboratories. PUBLIC HEALTH RELEVANCE: High-resolution peripheral quantitative computed tomography (HR-pQCT) and micro magnetic resonance imaging (5MRI), which are state-of-the-art clinical high-resolution imaging modalities for the skeleton, will be validated for the determination of mechanical competence and prediction of vertebral fractures. This research will test the feasibility and establish the standard of high-resolution skeletal imaging in assessing bone health beyond the areal bone mineral density measurements obtained by dual-energy x-ray absorptiometry (DXA).

描述（由申请人提供）：高分辨率成像的最新进展已经允许开发新工具，特别是微磁共振（5MR）成像和高分辨率外周定量计算机断层扫描（HR-pQCT），它们有望通过双能X射线骨密度测定（DXA）提供超越面积骨矿物质密度（aBMD）的更好的整体骨强度概况。在此应用中，我们试图确定基于图像的微观结构和 5FE 分析是否可以区分椎骨骨折的个体和没有椎骨骨折的个体。在拟议的项目中，我们提出以下假设：1.离体 5MRI 和 HR-pQCT 对远端胫骨和桡骨的刚度和失效载荷的形态测量和 5FE 预测与 5CT 和直接机械测试的结果高度相关，此外，来自两个外周部位的参数与椎骨中的参数平行。 2. 从体内 5MR 和 HR-pQCT 图像中得出的弹性刚度和失效载荷的 5FE 估计值可以比单独通过两种成像方式或通过 DXA 得出的 aBMD 得出的微观结构测量更好地区分椎骨骨折的个体和没有椎骨骨折的个体。我们计划通过以下具体目标来解决上述假设： 具体目标 1a：在体内可实现的信噪比和分辨率条件下，对远端胫骨和桡骨进行 5MRI 和 HR-pQCT 扫描，并将以此方式获得的小梁和皮质骨微结构测量值与高分辨率 5CT 的测量值进行比较。具体目标 1b：将 HR-pQCT 和基于 5MR 图像的非线性 5FE 分析预测的胫骨远端和桡骨整个骨段的刚度和失效载荷与基于 5CT 图像的 5FE 分析和直接机械测试预测的刚度和失效载荷进行比较。具体目标 2a：对与目标 1a 和 1b 中使用的远端胫骨和桡骨相同的受试者的腰椎进行 5CT 扫描 具体目标 2b：根据目标 1a 和 1b 中 HR-pQCT 和 5MRI 获得的成像数据，将小梁和皮质骨微结构测量和 5FE 预测与相应椎骨的 5CT 测量和直接机械测试进行比较 在目标 2a 中。具体目标 3a：将目标 1 和 2 中验证的微观结构和 5FE 技术应用于健康女性的体内 5MRI 和 HR-pQCT 扫描，并比较两种成像方式之间的这些测量结果。具体目标 3b：将目标 1 和 2 中验证的微观结构和 5FE 技术应用于两种外围成像模式，并使用研究人员实验室先前进行或当前正在进行的两项成像研究的数据来确定区分椎体骨折受试者和非骨折同伴的方法的有效性。 公众健康相关性：高分辨率外周定量计算机断层扫描 (HR-pQCT) 和微磁共振成像 (5MRI) 是最先进的临床高分辨率骨骼成像方式，将在确定机械能力和预测椎骨骨折方面得到验证。这项研究将测试可行性，并建立高分辨率骨骼成像评估骨骼健康的标准，超越双能 X 射线骨密度测量 (DXA) 获得的面积骨矿物质密度测量值。