Cancer Survivorship: Decreasing the Risk of Colon Cancer Mortality

描述（由申请人提供）：这是Polly Newcomb博士的既定研究者奖，他将30%的精力投入到结直肠癌幸存者的培训和研究中。她是一位经验丰富的癌症预防研究者，长期成功地获得了美国国立卫生研究院的资助。由于筛查和治疗的成功，癌症幸存者的人数正在迅速增长；今天，超过1100万美国人有癌症病史。结直肠癌是美国男性和女性癌症死亡的第二大原因。因此，确定提高结直肠癌患者生存率的方法是患者、临床医生和护理人员的当务之急。结肠癌是环境因素和遗传因素共同作用下的复杂疾病；诊断后的寿命也必须反映这些共同作用。K05奖项的目标是确定可改变和遗传因素，这些因素将改善男性和女性结直肠癌治疗后的生活质量并延长生存期。癌症生存是一个具有挑战性的预防研究领域，具有独特的分析和控制偏倚的方法，使其成为培训和发展初级研究人员的特别重要领域。在该奖项的支持下，Newcomb博士将投入15%的精力来指导新的癌症控制研究人员，并为结直肠癌生存率的关键研究提供基础。利用结肠癌家庭登记处（C-CFR），纽科姆博士是西雅图PI，拟议的研究将侧重于生活方式因素，如身体活动和营养，结直肠癌患者可以改变这些因素，以延长诊断后的寿命。在这些研究中，学员和初级教师还将考虑遗传学、病理特征、分子标记和治疗来评估复发和寿命的预测因素，为结直肠癌患者的生物学和护理提供见解。该奖项将是一个有价值的机制，以更好地了解可以提高生存率的因素，并在此过程中培养熟练的癌症控制研究人员。

DESCRIPTION (provided by applicant): This is an Established Investigator award for Dr. Polly Newcomb to dedicate 30% effort to training and research in colorectal cancer survivorship. She is an experienced cancer prevention investigator with a long and successful record of NIH-funding. The population of cancer survivors is rapidly growing because of screening and treatment successes; today more than 11 million U.S. individuals have a history of cancer. Colorectal cancer is the second leading cause of cancer death among men and women combined in the United States. Therefore, identifying approaches to improve survival in colorectal cancer patients is a high priority for patients, clinicians, and caregivers. Colon cancer is a complex disease caused by the joint action of multiple factors both environmental and genetic; longevity after diagnosis too must reflect these joint effects. The goal of this K05 award is to identify modifiable and genetic factors, which will improve quality of life and extend survival after treatment for colorectal cancer in men and women. Cancer survivorship is a challenging area of prevention research with unique methods for analyses and controlling bias, making it a particularly important area for the training and development of junior investigators. With the support provided by this award, Dr. Newcomb will dedicate 15% effort to mentoring new cancer control researchers and provide the foundation for key investigations in colorectal cancer survivorship. Utilizing the Colon Cancer Family Registries (C-CFR), for which Dr. Newcomb is the Seattle PI, the proposed research will focus on lifestyle factors, such as physical activity and nutrition that colorectal cancer patients can alter to enhance longevity after diagnosis. In these studies, trainees and junior faculty will also take into account genetics, pathological characteristics, molecular markers, and treatment to assess predictors of recurrence and longevity, providing insights into the biology and care for colorectal cancer patients. This award will be a valuable mechanism to better understand the factors that can enhance survival, and in doing so, develop skilled researchers in cancer control. PUBLIC HEALTH RELEVANCE: This study proposes to evaluate modifiable and genetic factors associated with survival after a diagnosis of colorectal cancer and to train early investigators in this important but complex area of cancer research. The genetic analyses will help scientists examine biological mechanisms associated with cancer survivorship. Also, findings from this study will inform clinicians about lifestyle factors, such as physical activity, that may influence outcomes in colorectal cancer patients, thereby potentially providing a means to increase survival.