Discovery of Natural Product based Drugs and Bioenergetic Materials from CR

从 CR 中发现基于天然产物的药物和生物能材料

基本信息

批准号：
7935324
负责人：
DAVID H SHERMAN
金额：
$ 95.41万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-11 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7935324
关键词：
Actinobacteria class Actinomyces Address Anabolism Area Bacteria Biodiversity Bioenergetics Bioinformatics Biological Factors Carboxy-Lyases Cellulases Chemicals Collaborations Collection Core Facility Costa Rica Costa Rican Country Coupled Cyanobacterium DNA DNA Sequence DNA Sequencing Facility Data Decarboxylation Development Disease Economic Development Economics Educational workshop Engineering Environment Enzymes Equipment and supply inventories Genetic Genome Genome Scan Genomics Habitats Health Human Hydrocarbons Hydrolase Hydrolysis Infectious Agent Insecta Institutes International Invertebrates Joints Lead Libraries Link Liquid substance Malaria Maps Marine Sediment Marines Metabolic Methods Michigan Microbe Microbiology Modification Myxococcales Nerve Degeneration Oxidoreductase Pathway interactions Pharmaceutical Preparations Pharmacologic Substance Phylogenetic Analysis Production Research Resource Sharing Resources Scientist Screening procedure Sequence Analysis Source Structure Students System Testing Therapeutic Agents Training Transcription Factor AP-1 Transcription Factor AP-2 Alpha United States National Institutes of Health Universities Viral Visit Water Work base benefit sharing cancer cell cellulase high throughput screening improved isoprenoid medical schools meter microbial microbial alkaline proteinase inhibitor microorganism next generation pathogen pre-clinical research programs rRNA Genes sugar thioester tool

项目摘要

DESCRIPTION (provided by applicant): The International Biodiversity Conservation Group (ICBG) program links three key issues, including human health, biodiversity conservation, and economic development by encouraging programs in the U.S. and programs in countries with high biodiversity to form integrated research teams. The ICBG described in this application involves programs located in the U.S. and Costa Rica that will cooperate to: Improve human health through the discovery of bioactive natural products from Costa Rica's rich biodiversity using ecologically-driven approaches. Contribute to the development of a bioenergy program toward discovery of cellulases and other enzymes for applications in biofuel production. Focus natural product and biosynthetic enzyme-related research on unexplored and under-explored microorganisms such as marine bacteria and insect microbial endosymbionts. Improve the research capacity and economic opportunities for Costa Rica and contribute to its National Biodiversity Strategy through gathering data for its biodiversity inventory, intensive screening of its natural products in medically relevant assays, high throughput testing of its hydrolytic enzymes, sharing of resources, clear benefit-sharing, and training of students and visiting scientists. These broad aims will be pursued through three Associate Programs located both in Costa Rica at the National Institute of Biodiversity (INBio), and the U.S. at Harvard Medical School (HMS) and the University of Michigan (U-M). The Associate Programs will conduct the pre-clinical research to discover, isolate, evaluate and develop therapeutic agents from natural products. Their collection programs, which will be coupled with genetic and phenotypic analyses, will expand Costa Rica's biodiversity inventory for microorganisms. Workshops and scientific exchanges will provide training opportunities. A bioenergy research program on sugar hydrolase discovery and commercial development is proposed as well as a program to harness enzymes from natural product biosynthesis (e.g., thioester hydrolases and decarboxylases) with application in liquid fuel production (biodiesel).

描述（由申请人提供）：国际生物多样性保护小组（ICBG）计划通过鼓励美国的计划和具有高生物多样性的国家的计划组成综合研究团队，将三个关键问题与包括人类健康，生物多样性保护和经济发展联系起来。本申请中描述的洲际弹道导弹涉及位于美国和哥斯达黎加的计划，该计划将通过生态驱动的方法从哥斯达黎加丰富的生物多样性中发现生物活性天然产品来改善人类健康。为在生物燃料生产中应用纤维素酶和其他酶的生物能源计划的发展做出贡献。将天然产物和生物合成酶相关的研究对未开发和探索的微生物（例如海洋细菌和昆虫微生物内共生菌）进行研究。通过收集其生物多样性库存的数据，在医学上相关的测定中对其自然产品进行密集筛查，对其水解酶的高吞吐量测试，共享资源共享，清晰的利益 - 分摊和培训学生和培训科学家，从而提高了哥斯达黎加的研究能力和经济机会，并为其国家生物多样性战略做出了贡献。这些广泛的目标将通过位于美国国家生物多样性研究所（INBIO）的哥斯达黎加的三个助理计划，以及哈佛医学院（HMS）和密歇根大学（U-M）的美国。副计划将进行临床前研究，以发现，隔离，评估和开发天然产品的治疗剂。他们的收集计划将与遗传和表型分析相结合，将扩大哥斯达黎加对微生物的生物多样性清单。讲习班和科学交流将提供培训机会。提出了一项关于糖水解酶发现和商业开发的生物能源研究计划，以及一项计划，以利用天然产物生物合成（例如硫酯水解酶和脱羧酶）中的酶以及在液体燃料生产（Biodiesel）中的应用。