Molecular toxinology of Australian box jellyfish venoms

澳大利亚箱形水母毒液的分子毒理学

• 批准号: nhmrc : 436606
• 负责人: A/Pr Graham Nicholson
• 金额: $ 18.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-toxinology-australian-jellyfish-venoms/99778
• 关键词: Molecular; toxinology; Australian; box; jellyfish

Box jellyfish are an ongoing cause of illness and death for coastal communities and tourist regions in northern Australia. As well as creating a significant medical problem, the resulting closure of beaches during boxjellyfish 'season' results in an enormous loss of tourism income and threatens Australia's reputation as a safe destination. The jellyfish venoms contain toxins with potentially lethal effects on humans. For the first time, using pure venoms derived from the specialised stinging cells (i.e. nematocytsts), we will isolate and characterize the major toxins from four species of box jellyfish. Their mechanism of action will be determined and the effect of various treatments such as antivenom will be investigated. This will also lead to the discovery of toxins with potentially novel targets and modes of action and increase our understanding of proposed treatments and prevention of stings.

箱形水母是澳大利亚北方沿海社区和旅游区疾病和死亡的持续原因。除了造成严重的医疗问题外，在箱水母“季节”期间关闭海滩还导致旅游收入的巨大损失，并威胁到澳大利亚作为安全目的地的声誉。水母的毒液含有对人类有潜在致命作用的毒素。对于第一次，使用纯毒液来自专门的刺细胞（即刺胞），我们将分离和表征的主要毒素从四种箱水母。将确定其作用机制，并研究抗蛇毒血清等各种治疗方法的效果。这也将导致发现具有潜在新靶点和作用模式的毒素，并增加我们对拟议治疗和预防蜇伤的理解。