Trauma Molecular Pathogenesis and Regeneration Training Grant

创伤分子发病机制和再生培训补助金

• 批准号: 8214779
• 负责人: RAPHAEL Carl LEE
• 金额: $ 5.69万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8214779
• 关键词: Grant; Molecular; Natural regeneration; Pathogenesis; Training; Trauma

DESCRIPTION (provided by applicant): This application seeks support to establish a new post-doctoral training program in the field of trauma medicine. The program is motivated by the growing integrative cross-disciplinary basic, clinical and translational research in the molecular pathogenesis and treatment of injury and is the outgrowth of well-established formal graduate courses(Appendix I-3) and research programs in tissue injury and repair at the University of Chicago. Our programmatic growth is driven by the large potential clinical impact resulting from research advances into new molecular regeneration trauma therapies, Molecular regeneration of cellular membranes and protein structure as an approach to trauma research had its beginnings at the University of Chicago more than 21 years ago and has now widely validated and emerging as a self-sustaining field of research . Today, there is sufficient established derivative research across various universities and companies to justify a formal educational program. Reversing the consequences of trauma requires recovery of the lost barrier function of membranes, reformation of native macromolecular structure, control of oxygen biochemistry, nucleic acid repair, and reestablishment of metabolic energy charge. New investigators in this new field must have competences in cellular physiology, membrane biophysics, protein chemistry, oxygen biochemistry, nucleic acid repair, animal research methods, clinical research guidelines, as well as computational and diagnostic imaging of molecular function. The proposed training program meets these requirements. The University of Chicago's Biological Sciences Division is an ideal site to launch such a training program. First, the University has well established and well funded research programs covering all of the mentioned areas mentioned and more. The research efforts here are interdisciplinary and integrated, setting the stage for discovery. There are many state of the art core facilities that are detailed in the proposal. Moreover, trainees will have access to a recently NIH grant funded super-computer with capabilities unprecedented in biomedicine to model molecular dynamics of trauma and behavior of synthetic chaperones to regenerate normal molecular structure. In addition, we already have in place a multi-year history of teaching now required graduate courses specifically focused on cell injury co-taught by the training program mentors. PUBLIC HEALTH RELEVANCE: In the United States, trauma is the primary cause of human morbidity and mortality in the first four decades of life resulting in an increasing population of young people with permanent disabilities . This comes as an enormous cost. This unique training program will prepare Physician Scientists for clinical or basic/translational research careers in understanding the molecular pathogenesis and molecular regeneration of injured tissue following trauma.

描述（由申请人提供）：本申请寻求支持以在创伤医学领域建立新的博士后培训计划。该计划是由损伤的分子发病机理和治疗中不断增长的综合跨学科基础，临床和转化研究的动机，这是芝加哥大学组织损伤和修复方面成熟的正式研究生课程（附录I-3）的生长。我们的程序化增长是由研究进展引起的新分子再生创伤疗法，细胞膜的分子再生和蛋白质结构所产生的巨大潜在临床影响驱动的，作为一种创伤研究的方法，它在21年前就在芝加哥大学开始了，现在已经广泛验证，并且已经广泛验证，并作为一个自我自我维护的研究领域。如今，各个大学和公司都有足够的既定衍生研究，以证明正式的教育计划是合理的。逆转创伤的后果需要恢复膜的失去障碍功能，天然大分子结构的改革，控制氧生物化学，核酸修复以及代谢能量电荷的重建。这个新领域的新研究人员必须具有细胞生理学，膜生物物理学，蛋白质化学，氧生物化学，核酸修复，动物研究方法，临床研究指南以及分子功能的计算和诊断成像。拟议的培训计划符合这些要求。 芝加哥大学的生物科学系是启动这种培训计划的理想场所。首先，该大学已经建立了良好的研究计划，涵盖了上述所有上述领域等等。这里的研究工作是跨学科和综合的，为发现奠定了基础。该提案中有许多最先进的核心设施。此外，学员将有能力访问具有生物医学中前所未有的能力的最近NIH赠款的超级计算机，以模拟创伤的分子动力学和合成伴侣的行为，以再生正常的分子结构。此外，我们已经拥有了多年的教学历史，现在需要专门针对培训计划导师共同教授的细胞伤害的研究生课程。 公共卫生相关性：在美国，创伤是人类发病率和死亡率的主要原因，导致越来越多的永久残疾年轻人人口越来越多。这是一笔巨大的成本。该独特的培训计划将为医师科学家准备临床或基本/转化研究职业，以了解创伤后受伤组织的分子发病机理和分子再生。