Apollo: Increasing Access and Use of Epidemic Models Through the Development and

Apollo：通过开发和应用增加流行病模型的获取和使用

• 批准号: 8273693
• 负责人: WILLIAM R HOGAN
• 金额: $ 58.41万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-18 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8273693
• 关键词: Address; Algorithms; Bioterrorism; Centers for Disease Control and Prevention (U.S.); Client; Clinical; Complex; Computer software; Data; Decision Making; Development; Disease; Disease Outbreaks; Epidemic; Evolution; Extensible Markup Language; Future; Health; Health Status; Hour; Influenza A Virus, H1N1 Subtype; Intervention; Language; Measures; Modeling; National Institute of General Medical Sciences; Ontology; Output; Pharmacologic Substance; Plug-in; Policies; Population; Principal Investigator; Public Health Practice; Research; Research Personnel; Running; Science; Security; Societies; Standardization; Structure; Supercomputing; System; Terminology; Time; Translating; United States Dept. of Health and Human Services; Universities; Vaccination; Vocabulary; Voting; Washington; Weather; Work; authority; base; computer program; design; disease transmission; disorder control; experience; infectious disease model; meetings; member; open source; outreach; pandemic disease; research and development; research study; response; retinal rods; software development; supercomputer; syntax; tool; web services; working group

DESCRIPTION (provided by applicant): The broad aim of the proposed work is to make epidemic models as readily available to health agencies, and as easy-to-use as are weather models for local TV stations. The project will standardize the vocabulary and syntax used in epidemic modeling. By standardizing the many parameters that epidemic models require to represent disease transmission, the health status of a population, disease transmission, and disease control measures, the project will decrease the time and effort required to develop epidemic models and will make them more available to scientific and clinical users of these models. The specific aims are to (1) develop a standard vocabulary for the field of epidemic modeling using a tool called Prot¿g¿; (2) create two extensions to Prot¿g¿ that are needed by the project; (3) develop a standard syntax using the vocabulary for representing the inputs (e.g., disease control measures) and outputs of epidemic models and to use this syntax in an existing system called the Apollo Web Service that makes it possible for other computer programs to access epidemic models; and (4) to increase the capacity to run epidemic models on supercomputers so as to demonstrate the value of the work of the first three aims. The project will work with epidemic modelers from the MIDAS research network to develop the standard vocabulary and syntax. It will use the extended Prot¿g¿ software to develop the standard vocabulary as an ontology, which is a formal representation of objects and their interrelations. It will represent syntax using the XML language. An analysis of the input and output data currently used by epidemic models will drive the design of the syntax. The expected impact of the proposed research is that state and federal officials with responsibility t respond to epidemics will routinely and effortlessly incorporate the predictions of epidemic models into their decision making, thereby increasing significantly the value of the science of epidemic modeling to society. PUBLIC HEALTH RELEVANCE: Project Narrative The relevance to public health of standardizing the vocabulary and syntax used to represent disease control measures and data about population health is that it will improve the nation's ability to choose the best measures to control epidemics. It will also reduce the effort and cost of developing the epidemic models used in making these choices, and improve access to the models.

描述(由申请人提供)：拟议工作的广泛目标是使流行病模型易于卫生机构获得，并像地方电视台的天气模型一样易于使用。该项目将标准化流行病建模中使用的词汇和语法。通过标准化流行病模型所需的许多参数来表示疾病传播、人口健康状况、疾病传播和疾病控制措施，该项目将减少开发流行病模型所需的时间和精力，并使这些模型的科学和临床用户更容易获得这些模型。其具体目标是(1)使用名为Prot？g？的工具为流行病建模领域开发标准词汇表；(2)创建项目所需的两个Prot？g扩展；(3)使用表示流行病模型的输入(例如，疾病控制措施)和输出的词汇表开发标准语法，并在称为Apollo Web Service的现有系统中使用该语法，该系统使其他计算机程序能够访问流行病模型；(4)提高在超级计算机上运行流行病模型的能力，以显示前三个目标的工作价值。该项目将与MIDAS研究网络的流行病建模人员合作，开发标准词汇和语法。它将使用扩展的PROT软件将标准词汇开发为本体，本体是对象及其相互关系的形式化表示。它将使用XML语言表示语法。对流行病模型当前使用的输入和输出数据的分析将推动语法的设计。这项拟议研究的预期影响是，负责应对流行病的州和联邦官员将例行公事地毫不费力地将流行病模型的预测纳入他们的决策，从而显著增加流行病建模科学对社会的价值。 公共卫生相关性：项目叙述标准化用于表示疾病控制措施和人口健康数据的词汇和句法与公共健康的相关性在于，它将提高国家选择控制流行病的最佳措施的能力。它还将减少开发用于做出这些选择的流行病模型的工作量和成本，并改善对模型的获取。