Tumor Imaging

项目总结(见说明)： 肿瘤影像 肿瘤成像计划的研究重点是使用医学成像来诊断、治疗和评估肿瘤的治疗反应。该计划成员的总体目标是开发在癌症研究中使用医学成像的新方法，并扩展现有的成像能力，以优化诊断、分期、治疗和对治疗反应的评估。在该计划的研究中有三个主要重叠的主题。第一个主题是新陈代谢成像。这一主题的重点研究领域包括调查人员评估 对治疗的反应以及其他探索新型分子显像剂的研究。第二个主题是放射肿瘤学中的影像。这一主题的重点研究领域包括评估提高图像引导放射治疗精度的方法，以及探索增强氧化代谢定量成像的方法的研究。第三个主题是诊断成像。本主题的重点研究领域包括神经内分泌肿瘤的研究和肺结节的成像。该计划的成员成功地支持了这所大学 爱荷华州成像响应评估团队，最近获得了NCI U01 “定量成像评估癌症治疗试验中的反应”。在肿瘤影像计划的成员之间，以及与其他癌症中心计划的成员之间，过去和现在都有许多富有成效的合作。该计划由来自2所学院2个基础科学和4个临床科室的26名成员组成。经同行评审，该项目的研究资金总额为5,394,961美元，其中1,035,638美元来自NCI。项目成员发表了184篇与癌症相关的文章 上一次资助期间的论文。在这些出版物中，23%是方案内出版物。 15%是方案间出版物，18%既是方案内出版物，也是方案间出版物，总共有56%的协作性出版物。

PROJECT SUMMARY (See instructions): Tumor Imaging Research in the Tumor Imaging Program focuses on the use of medical imaging for the diagnosis, treatment and assessment of response to therapy of tumors. The overall goal of the members of this program is to develop new approaches to use medical imaging in cancer research and to extend current imaging capabilities to optimize diagnosis, staging, treatment and assessment of response to therapy. There are 3 major overlapping themes within the Program's research. The first theme is Metabolic Imaging. Highlighted research areas within this theme include investigators assessing response to therapy as well as others exploring novel molecular imaging agents. The second theme is Imaging in Radiation Oncology. Highlighted research areas within this theme include evaluation of approaches to enhance the precision of image-guided radiation therapy, and studies exploring approaches to enhance quantitative imaging of oxidative metabolism. The third theme is diagnostic imaging. Highlighted research areas in this theme involve study of neuroendocrine tumor and imaging of lung nodules. Members of the program have been successful in supporting the University of lowa Imaging Response Assessment Team and recently obtained an NCI U01 entitled "Quantitative Imaging to Assess Response in Cancer Therapy Trials". There are numerous past and present productive collaborations both between members of the Tumor Imaging Program, and with members of other Cancer Center programs. The program consists of 26 members from 2 basic science and 4 clinical departments in 2 Colleges. Peer-reviewed, research funding for this program totals $5,394,961 with $1,035,638 coming from the NCI. Program members published 184 cancer related papers over the prior funding period. Of these publications, 23% were intraprogrammatic. 15% were interprogrammatic and 18% were both intra and interprogrammatic, for a total of 56% collaborative publications.