Shared Resources - Small Animal Imaging

小动物成像核心(SAIC) 小动物成像核心的目的是通过为小鼠和大鼠的非侵入性解剖和生理成像提供全面的服务来协助HCCC调查人员。核心的最终产品包括在与癌症生物学、药物开发和治疗干预评估相关的科学研究中纵向获取的定量图像数据集。核心的基本服务是 1)成像模式选择和成像方案制定的咨询服务，2)协助ACURF和其他法规提交， 3)动物准备和监测； 4)单通道或多通道成像，以及 5)图像重建、数据分析和结果解释。 核心拥有和直接操作的小动物专用仪器由几种成像方式组成，包括PET、SPECT、伽马相机成像、放射自显影和CT。此外，附近的实验室还提供小动物核磁共振、超声波和光学成像。核心运营着一个小型图像处理实验室，包括4个高端工作站，以及一套可供使用的多模式软件，包括Pmod和Inveon Research Workspace，两者都配备了完整的3D和药代动力学软件包。核心还拥有自己的12 TB RAID5网络归档系统，镜像到异地研究网络存储。将所有高端小动物成像设备整合到一个空间中 小动物成像核心将随着Pappajohn Biomedical Discovery大楼(目前正在建设中-预计将于2014年投入使用)的竣工而进行，其中10个专用小动物成像套件和8个成像支持实验室将容纳所有SAIC成像技术。这一战略旨在利用小动物成像提供高效、专业、方便和具有成本效益的成像设备和专业知识。

Small Animal imaging Core (SAIC) The purpose of the Small Animal Imaging Core is to assist HCCC investigators by providing a comprehensive service for non-invasive anatomical and physiological imaging of mice and rats. The ultimate product of the core consists of quantitative image datasets taken longitudinally in scientific studies related to cancer biology, drug development, and assessment of therapeutic intervention. The basic services of the core are 1) Consultative service for imaging modality choice and imaging protocol development, 2) Assistance with ACURF and other regulatory submissions, 3) Animal preparation and monitoring, 4) Single or multiple modality imaging, and 5) Image reconstruction, data analysis, and results interpretation. The small animal specific instrumentation owned and operated directly by the core consists of several imaging modalities including PET, SPECT, gamma camera imaging, autoradiography, and CT. Additionally small animal MRI, ultrasound and optical imaging are available in nearby laboratories. The Core operates a small image processing laboratory including 4 high-end workstations with a suite of multi-modality software available for use, including PMOD, and Inveon Research Workspace, both fully equipped with 3D and pharmacokinetic packages. The core also has its own 12 TB RAID5 networked archive system, mirrored to offsite research networked storage. Consolidation of all high end small animal imaging equipment into a single space under the Small Animal Imaging Core will take place with the completion of the Pappajohn Biomedical Discovery Building (presently under construction - occupancy expected in 2014) where ten dedicated small animal imaging suites, and eight imaging support laboratories will house all SAIC imaging technologies. This strategy is designed to provide efficient, professional, convenient and cost-effective access to imaging equipment and expertise using small animal imaging.