Shared Resources - Small Animal Imaging

小动物成像核心 (SAIC) 小动物成像核心的目的是通过为小鼠和大鼠的非侵入性解剖和生理成像提供全面的服务来协助 HCCC 研究人员。核心的最终产品包括在与癌症生物学、药物开发和治疗干预评估相关的科学研究中纵向采集的定量图像数据集。核心的基本服务是 1) 成像模式选择和成像方案开发的咨询服务，2) 协助 ACURF 和其他监管提交， 3）动物准备和监测， 4) 单模态或多模态成像，以及 5）图像重建、数据分析和结果解释。 核心直接拥有和操作的小动物专用仪器由多种成像模式组成，包括 PET、SPECT、伽玛相机成像、放射自显影和 CT。此外，附近的实验室还提供小动物 MRI、超声波和光学成像。 Core 运营着一个小型图像处理实验室，包括 4 个高端工作站，配有一套可供使用的多模态软件，包括 PMOD 和 Inveon Research Workspace，两者均配备了 3D 和药代动力学软件包。该核心还拥有自己的 12 TB RAID5 网络存档系统，镜像到异地研究网络存储。将所有高端小动物成像设备整合到一个空间中 小动物成像核心项目将随着 Pappajohn 生物医学探索大楼（目前正在建设中 - 预计于 2014 年入住）的竣工而展开，其中 10 个专用小动物成像套件和 8 个成像支持实验室将容纳所有 SAIC 成像技术。该战略旨在提供高效、专业、便捷且经济高效的小动物成像成像设备和专业知识。

Small Animal imaging Core (SAIC) The purpose of the Small Animal Imaging Core is to assist HCCC investigators by providing a comprehensive service for non-invasive anatomical and physiological imaging of mice and rats. The ultimate product of the core consists of quantitative image datasets taken longitudinally in scientific studies related to cancer biology, drug development, and assessment of therapeutic intervention. The basic services of the core are 1) Consultative service for imaging modality choice and imaging protocol development, 2) Assistance with ACURF and other regulatory submissions, 3) Animal preparation and monitoring, 4) Single or multiple modality imaging, and 5) Image reconstruction, data analysis, and results interpretation. The small animal specific instrumentation owned and operated directly by the core consists of several imaging modalities including PET, SPECT, gamma camera imaging, autoradiography, and CT. Additionally small animal MRI, ultrasound and optical imaging are available in nearby laboratories. The Core operates a small image processing laboratory including 4 high-end workstations with a suite of multi-modality software available for use, including PMOD, and Inveon Research Workspace, both fully equipped with 3D and pharmacokinetic packages. The core also has its own 12 TB RAID5 networked archive system, mirrored to offsite research networked storage. Consolidation of all high end small animal imaging equipment into a single space under the Small Animal Imaging Core will take place with the completion of the Pappajohn Biomedical Discovery Building (presently under construction - occupancy expected in 2014) where ten dedicated small animal imaging suites, and eight imaging support laboratories will house all SAIC imaging technologies. This strategy is designed to provide efficient, professional, convenient and cost-effective access to imaging equipment and expertise using small animal imaging.