Ohio State Neuroscience Centr Core

俄亥俄州立神经科学中心核心

• 批准号: 8211340
• 负责人: KARL H OBRIETAN
• 金额: $ 20.81万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8211340
• 关键词: Animal Model; Aquaculture; Basic Science; Biological Models; Development; Disease; Etiology; Faculty; Funding; Generations; Genetic; Genome; Grant; Knock-in Mouse; Knock-out; Knockout Mice; Modeling; Mus; National Institute of Neurological Disorders and Stroke; Neurobiology; Neurosciences; Ohio; Paper; Phase; Qualifying; Research; Research Personnel; Research Project Grants; Services; Transgenic Mice; Transgenic Mouse Facility; Transgenic Organisms; Zebrafish; cost; innovation; mouse model; nervous system disorder; novel

CORE B: GENETICS CORE The purpose of this Core is to provide support for transgenic mouse and zebrafish research. This Core will facilitate current NINDS-funded research and stimulate synergistic Interactions between diverse Investigators using different animal model systems. This support will benefit all investigators by subsidizing costs and providing advanced genome editing services and aquaculture services. The Genetics Core has two components, each with its own faculty Director. I. Transgenic Mice Core Overview The aim of this Core is to support the development of novel mouse models that will facilitate NINDS-funded researchers and stimulate synergistic interactions between Pis in the OSU Neuroscience Center. Because the Core will subsidize the cost of making transgenic and knockout mice, it will support new investigators to develop mouse models which otherwise could be cost prohibitive. This support will be provided by subsidizing costs of generating transgenic and knockout mouse lines and subsidizing the per diems during the initial expansion and characterization phase of the mouse line. Over the 4.5 years of the grant 43 transgenic mice were generated using Core Support benefiting four Pis (Oberdick, Burghes, Obrietan, Yoon). This Core component was cited in twelve papers and led to two new R01s. The projected need for the renewal is forty two transgenics and ten knock outs benefiting ten Pis. Thus, this is a valued, productive Core.

核心B：遗传学核心 该核心的目的是为转基因小鼠和斑马鱼研究提供支持。该核心将促进目前NINDS资助的研究，并刺激使用不同动物模型系统的不同研究者之间的协同互动。这项支持将通过补贴成本和提供先进的基因组编辑服务和水产养殖服务使所有研究人员受益。遗传学核心有两个组成部分，每个都有自己的教师主任。 I.转基因小鼠核心 概述 该核心的目的是支持新型小鼠模型的开发，这将促进NINDS资助的研究人员，并刺激OSU神经科学中心Pis之间的协同作用。由于核心将补贴制造转基因和基因敲除小鼠的成本，它将支持新的研究人员开发小鼠模型，否则成本可能过高。这种支持将通过补贴 产生转基因和敲除小鼠品系的成本以及在小鼠品系的初始扩增和表征阶段期间补贴每日津贴的成本。在授予的4.5年中，使用核心支持产生了43只转基因小鼠，其中4只Pis（Oberdick，Burdick，Obrietan，Yoon）受益。该核心组件在12篇论文中被引用，并导致了两个新的R01。预计需要更新的是42 转基因技术和十次击倒使十个私家侦探受益因此，这是一个有价值的、有生产力的核心。