Monitoring of leucocyte cytokine-chemokines to improve morbidity and rejection rates in lung transplant patients

监测白细胞细胞因子趋化因子以改善肺移植患者的发病率和排斥率

• 批准号: nhmrc : 508121
• 负责人: A/Pr Daniel Chambers
• 金额: $ 24.94万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/monitoring-leucocyte-cytokine-transplant-patients/83174
• 关键词: Monitoring; leucocyte; cytokine; chemokines; improve

Lung transplantation has become established therapy for many serious lung diseases. The early success rate is now very good, but at five years after transplant the survival rate is only around 60%. This problem is largely due to chronic graft failue as a result of chronic rejection or bronchiolitis obliterans syndrome. This project will specifically investigate the causes of BOS and thereby provide new information on how we may best treat this problem. An improvement in this area is critical.

肺移植已成为许多严重肺部疾病的既定治疗方法。早期的成功率现在很好，但移植后五年的存活率只有60%左右。这个问题很大程度上是由于慢性排斥反应或闭塞性细支气管炎综合征导致的慢性移植失败。这个项目将专门调查BOS的原因，从而为我们如何最好地处理这个问题提供新的信息。这方面的改进至关重要。