Modulation of lung regeneration and remodeling by the innate immune system.

先天免疫系统调节肺再生和重塑。

• 批准号: nhmrc : 1147256
• 负责人: A/Pr Daniel Chambers
• 金额: $ 39.42万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-lung-regeneration-immune-system/1320805
• 关键词: Modulation; lung; regeneration; remodeling; innate

Idiopathic pulmonary fibrosis results in respiratory failure and death with millions of people affected each year. Current treatments are limited and there is a need to better understand the changes that drive fibrosis. In this study we will investigate how the innate immune system modulates the process of epithelial regeneration, focusing, in particular, on how the innate immune response following severe lung injury initiates a disordered repair processes and drives fibrosis.

特发性肺纤维化导致呼吸衰竭和死亡，每年有数百万人受到影响。目前的治疗方法有限，需要更好地了解导致纤维化的变化。在这项研究中，我们将研究先天免疫系统如何调节上皮再生过程，特别关注严重肺损伤后的先天免疫反应如何启动无序的修复过程并驱动纤维化。