Combining immune monitoring and immunotherapy to tackle cytomegalovirus infections in solid organ transplant patients

结合免疫监测和免疫治疗来应对实体器官移植患者的巨细胞病毒感染

• 批准号: nhmrc : 1062074
• 负责人: A/Pr Daniel Chambers
• 金额: $ 53.44万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/combining-immune-monitoring-transplant-patients/454958
• 关键词: Combining; immune; monitoring; immunotherapy; tackle

Clinical management of infectious complications in kidney and heart/lung transplant patients remains significant challenge. Although prophylactic/pre-emptive treatment with antiviral drugs have shown dramatic improvements in the control of these infections, long-term treatment with these drugs is associated with significant toxicity, the appearance of drug-resistant virus isolates and significant health cost. In this proposal we will develop novel strategies to identify high risk patients and treat these patients with killer T cells.

肾和心/肺移植患者感染并发症的临床管理仍然是一个重大挑战。虽然用抗病毒药物进行预防性/先发制人的治疗在控制这些感染方面显示出显著的改善，但用这些药物进行长期治疗与显著的毒性、耐药病毒分离株的出现和显著的健康成本相关。在这项提案中，我们将开发新的策略来识别高风险患者，并用杀伤性T细胞治疗这些患者。