Hyperpolarized C-13 MR Pulse Sequence Developments for Novel Contrast

用于新型对比度的超极化 C-13 MR 脉冲序列开发

• 批准号: 8327061
• 负责人: Peder Eric Zufall Larson
• 金额: $ 22.81万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8327061
• 关键词: Animals; Award; Bicarbonates; Biochemistry; Biological; Biological Markers; Biomedical Engineering; Blood; Cancer Patient; Carbon; Chemistry; Collaborations; Complex; Detection; Development; Development Plans; Disease; Electrical Engineering; Engineering; Exposure to; Faculty; Future; Goals; Human; Image; Imaging Techniques; Investigation; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Mentors; Metabolic; Metabolism; Methods; Mus; New Agents; Pathology; Pathway interactions; Perfusion; Physics; Physiologic pulse; Pyruvate; Pyruvate Metabolism Pathway; Radiology Specialty; Reproducibility; Research; Research Personnel; Scheme; Signal Transduction; Solid; Source; Techniques; Time; Tissues; Translations; Urea; Wild Type Mouse; Work; abstracting; base; bioimaging; biological systems; cancer imaging; career development; clinical application; design; imaging modality; improved; in vivo; interest; member; method development; novel; pre-clinical research; preclinical study; reconstruction; response; tumor; uptake

Project Summary/Abstract This project outlines technical bioengineering developments for new types of image contrast in the emerging field of hyperpolarized carbon-13 MRI. Preliminary research in this field is extremely promising, particularly for cancer applications, and the first human trials in prostate cancer patients are slated to occur at UCSF within 6 months. This "Pathway to Independence" award application includes a mentored career development plan for transition of the candidate, Dr. Peder Larson, into an independent investigator, as well an accompanying research plan describing the proposed technical developments for hyperpolarized carbon-13 MR. The candidate, Dr. Peder Larson, is currently a Postdoctoral Scholar at UCSF working on technical developments for hyperpolarized carbon-13 MRI. His graduate work was in Electrical Engineering at Stanford and focused on improving MRI of semi-solid tissues, which are invisible in conventional MRI. The mentoring and career development plan will supplement his engineering background with valuable exposure to hyperpolarization physics and chemistry, biological systems and biochemistry, pre-clinical research, and inter-disciplinary collaboration to facilitate the transition to an independent bioengineering investigator. His goals are to become a faculty member in bioengineering or radiology where he can research technical biomedical imaging developments with potential clinical applications. Hyperpolarized carbon-13 MRI requires specialized methods because, unlike conventional MRI, the signal decays rapidly and is unrecoverable. This project proposes rapid and efficient methods for dynamic metabolic imaging to provide localized perfusion, uptake and rate information that are unavailable in current techniques. New sources of contrast with hyperpolarized carbon-13 are also proposed, including a method to distinguish flowing metabolites from those within tissues and development of specialized techniques for multiple carbon-13 agents. Preclinical studies in normal animals will be used for investigation of the new imaging methods. This will facilitate the translation of the methods from development to future clinical application. ) )

项目总结/文摘