Biobehavioral Bases of CHD Risk and Management

CHD 风险和管理的生物行为基础

• 批准号: 7434375
• 负责人: NEIL SCHNEIDERMAN
• 金额: $ 221.48万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434375
• 关键词: Biobehavioral; Bases; CHD; Risk; Management

DESCRIPTION (provided by applicant): This program project competitive renewal application consists of an integrated, multidisciplinary program including 3 closely related projects examining the preclinical and/or clinical markers of coronary heart disease (CHD) risk associated with type 2 diabetes, metabolic syndrome or hyperlipidemia and their involvement in the progression or amelioration of atherosclerotic CHD processes. In each project we will examine the modification of risk factors through the use of behavioral interventions such as dietary restriction, exercise, stress management and/or manipulations of social environment. Outcome variables will include measures of glycemic control/insulin resistance and/or dyslipidemia, oxidative stress, inflammation and overt manifestations of disease. The first Project will determine if compared to Standard Care (SC), a Community Approach to Lifestyle Modification for Diabetes (CALM-D) program including diet, physical activity and coping skills training, can decrease depression, weight and HbA1c and improve medication adherence in low income, minority, depressed, overweight, type 2 diabetic patients seen in a large comprehensive community health center. The second Project will determine if compared to SC, a Community Health and Risk-reduction in Metabolic Syndrome (CHARMS) program also including diet, physical activity and coping skills training, can decrease weight, increase physical activity and reduce the frequency and severity of metabolic syndrome. The third project will assess the role of behavior in the progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit by examining the influence of social environment on hyperlipidemic, oxidative, and inflammatory disease processes. The projects will interact with and rely heavily on, the Biochemical Analyses Core, the Cardiovascular Measurement Core and the Data Management and Statistical Analyses Core.

描述(由申请人提供)： 该计划项目竞争续签申请包括一个综合的多学科计划，其中包括3个密切相关的项目，检查与2型糖尿病、代谢综合征或高脂血症相关的冠心病(CHD)风险的临床前和/或临床标记物，以及它们在动脉粥样硬化性CHD过程的进展或改善中的参与。在每个项目中，我们将通过使用行为干预措施，如限制饮食、锻炼、压力管理和/或操纵社会环境，来检查风险因素的改变。结果变量将包括血糖控制/胰岛素抵抗和/或血脂异常、氧化应激、炎症和疾病的明显表现。第一个项目将确定与标准护理(SC)相比，社区糖尿病生活方式调整(CAMP-D)计划是否可以减少抑郁、体重和糖化血红蛋白，并提高大型综合性社区卫生中心看到的低收入、少数族裔、抑郁、超重和2型糖尿病患者的用药依从性。第二个项目将确定与SC相比，社区健康和新陈代谢综合征风险降低(CHARMS)计划是否可以减轻体重、增加体力活动并降低代谢综合征的频率和严重程度。第三个项目将通过研究社会环境对高脂血症、氧化和炎症性疾病过程的影响，评估行为在渡边遗传性高脂血症兔动脉粥样硬化进展中的作用。这些项目将与生化分析核心、心血管测量核心以及数据管理和统计分析核心相互作用，并严重依赖它们。