BIOBEHAVIORAL BASES OF CHD RISK AND MANAGEMENT

先心病风险和管理的生物行为基础

• 批准号: 6921965
• 负责人: NEIL SCHNEIDERMAN
• 金额: $ 193.5万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6921965
• 关键词: behavioral medicine; cardiovascular disorder; disease /disorder proneness /risk; human subject; patient oriented research

PROPOSED PROGRAM (provided by applicant): This program project competitive renewal consists of an integrated, multidisciplinary program including 3 closely related projects examining the progression of atherosclerosis and/or its amelioration, which is supported by 4 core units. Project 1, which would be conducted upon adolescents with persistently elevated blood pressure, would examine the effects of a behavioral intervention involving diet, exercise and stress management counseling. This project would assess the impact of the intervention on cardiovascular risk factors (e.g., lipid profiles, adiposity, inflammatory markers) and putative subclinical markers of disease (e.g., left ventricular mass, endothelial function). Project 2 would examine the effects of individual and group based cognitive behavior therapy (CBT) in acute myocardial infarction (AMI) patients who are at increased risk for medical morbidity and mortality after AMI because they are socially isolated or clinically depressed. Participants randomized into a CBT or usual care condition will be assessed in terms of biological risk factors (e.g., lipids, adiposity, coagulation factors) and possible subclinical markers of disease (e.g., carotid intima-media thickness, coronary calcification). The third project, which will be conducted on Watanabe Heritable Hyperlipidemic Rabbits (WHHL) will assess the role of: (a) the sympathetic nervous system (SNS) in behaviorally-related atherosclerosis; (b) corticotropin-releasing hormone in regulating SNS activity and progression of atherosclerosis during chronic social stress; (c) oxytocin (OT) in the hypothalamus as a function of social environment; and (d) OT in the regulation of hypothalamic pituitary adrenocortical and SNS activity in relation to the progression of behaviorally-related atherosclerosis. These 3 projects will each be supported by Administrative, Endocrinology and Metabolism, Cardiovascular Management and Statistics/Data Management units.

建议课程(由申请人提供)： 本计划项目竞争续订由一个完整的、 多学科计划包括3个密切相关的项目 动脉粥样硬化的进展和/或其改善，这是由 4个核心单元。项目1，该项目将针对患有 持续升高的血压，将检查一种 包括饮食、锻炼和压力管理的行为干预 心理咨询。该项目将评估干预措施对 心血管危险因素(例如，血脂、肥胖症、炎症 标记物)和假定的亚临床疾病标记物(例如左心室 质量、内皮功能)。项目2将审查以下项目的影响 以个体和群体为基础的认知行为疗法(CBT) 心肌梗死(AMI)患者接受医疗服务的风险增加 急性心肌梗死后的发病率和死亡率，因为他们与社会隔离或 临床忧郁症。参与者随机分为CBT组或常规护理组 将根据生物风险因素(例如，血脂、 肥胖、凝血因子)和可能的亚临床疾病标志物 (例如，颈动脉内膜中层厚度、冠状动脉钙化)。第三 该项目将在渡边遗传性高脂血症兔身上进行 (WHHL)将评估：(A)交感神经系统(SNS)在 行为相关动脉粥样硬化；(B)促肾上腺皮质激素释放激素在 慢性动脉粥样硬化中调节SNS活性和进展的研究 社会应激；(C)下丘脑中催产素(OT)作为社会应激的函数 (D)OT在下丘脑-垂体调节中的作用 肾上腺皮质和SNS活性与糖尿病进展的关系 行为相关的动脉粥样硬化。这3个项目将分别得到支持 按行政、内分泌和新陈代谢、心血管管理和统计/数据管理单位分列。