Young Sexual Minority Women's Mental Health: Developmental Trajectories, Mechanisms of Risk, and Protective Factors.

年轻性少数女性的心理健康：发展轨迹、风险机制和保护因素。

• 批准号: 10635506
• 负责人: SARAH W WHITTON
• 金额: $ 80.44万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10635506
• 关键词: Address; Adolescence; Affect; Age; Anxiety; Anxiety Disorders; Attention; Behavioral; Biological; Biological Markers; Biological Process; Black race; Buffers; C-reactive protein; Childhood; Communities; Coping Skills; Data; Data Set; Development; Disparity; Economics; Face; Family; Feeling hopeless; Funding; Gender; Gender Identity; Goals; Grant; Heterosexuals; Impairment; Individual; Inflammatory; Interleukin-10; Interleukin-6; Intervention; Knowledge; Latinx; Lesbian Gay Bisexual; Lesbian Gay Bisexual Transgender; Longitudinal Studies; Longitudinal cohort study; Measurement; Mediating; Mental Depression; Mental Health; Mental disorders; Minority; Modeling; National Institute of Child Health and Human Development; National Institute of Mental Health; Participant; Pathological anxiety; Pattern; Policies; Process; Public Health; Race; Reporting; Research; Resources; Risk; Risk Factors; Sampling; Self-Injurious Behavior; Severities; Sex Orientation; Sexual Health; Sexual and Gender Minorities; Skin; Social Processes; Social isolation; Strategic Planning; Stress; Suicide; Symptoms; Testing; United States National Institutes of Health; Victimization; Violence; Vulnerable Populations; Woman; cognitive process; depressive symptoms; design; emerging adult; emotion regulation; evidence base; experience; family support; gender minority group; gender minority health; health disparity; health equity; improved; innovation; interest; men; minority stress; minority stressor; multi-racial; negative affect; non-heterosexual; nonbinary; prevent; programs; prospective; protective effect; protective factors; psychologic; psychological symptom; racial diversity; rumination; sexual minority; sexual minority group; sexual minority men; sexual minority women; social; social stigma; suicidal; systemic inflammatory response; theories; therapy development; young adult

Sexual minority women experience alarmingly high rates of mental health problems, including anxiety disorders, depression, and suicidality, which are significantly higher than those of both heterosexual women and sexual minority men. The overarching goals of this project are to address these mental health disparities and advance our ability to prevent and treat mental illness among sexual minority women by conducting an innovative, longitudinal study of mental health in young sexual minority women. Building upon the largest ever longitudinal cohort study of young sexual minority women, which includes seven waves of data collected over 3 years from 390 racially diverse participants (ages 16-20 at baseline), we will collect an additional six waves of data over 2.5 years (starting at ages 21-26) with expanded measurement of mental health, risk and protective factors, and mechanisms of effect. We have four specific aims: (1) Model trajectories of sexual minority women’s mental health, including depression, anxiety, and suicidality across late adolescence and early adulthood (16-28 years), and explore demographic differences in these patterns (e.g., by race, gender identity). (2) Grounded in minority stress theory, rigorously test unique stigma-based risk factors for mental health among sexual minority women. (3) Explore biological, psychological, and social/interpersonal mechanisms through which minority stress negatively affects sexual minority women’s mental health. Specifically, we will test whether stress-sensitive inflammatory processes (C- reactive protein, IL-6, IL-10, TNFa), maladaptive emotion regulation and cognitive processes (e.g., rumination; hopelessness), and impaired social processes (social isolation; romantic relationship functioning) mediate associations between minority stress and mental health. (4) Identify individual, community, and interpersonal protective factors that buffer sexual minority women from adverse mental health effects of minority stress. Across aims, the project focuses on identifying mutable factors that can be targeted in interventions and are relevant to today’s young sexual minority women, who are diverse in race, gender identity, and specific sexual orientation identity. Findings will be used to inform development of evidence-based, culturally sensitive interventions to prevent and treat mental illness in this vulnerable group. This proposal is responsive to NOT-MD-19-001(Notice of Special Interest in Research on the Health of SGM Populations), which encourages research describing biological and social processes affecting the health of sexual and gender minorities (SGM) that will lead to the development of interventions to enhance SGM health.

性少数族裔妇女的心理健康问题率令人震惊，包括焦虑 疾病，抑郁和自杀性明显高于两位异性妇女 和性少数人。该项目的总体目标是解决这些心理健康分布 并提高我们通过进行性少数族裔妇女预防和治疗精神疾病的能力 年轻性少数妇女心理健康的创新，纵向研究。建立有史以来最大的 年轻性少数妇女的纵向队列研究，其中包括七个超过3的数据浪潮 从390个不同的参与者（基线时16-20岁）的年份，我们将额外收集六波浪潮 数据超过2。5年（从21-26岁开始），并扩大了对心理健康，风险和保护性的测量 因素和效果机制。我们有四个具体的目标：（1）性少数群体的模型轨迹 妇女的心理健康，包括青春期晚期和早期的抑郁症，焦虑和自杀 成年（16-28岁），并探索这些模式的人口统计学差异（例如，种族，性别 身份）。 （2）以少数族裔压力理论为基础，严格测试基于污名的唯一污名风险因素 性少数妇女的健康。 （3）探索生物学，心理和社会/人际关系 少数压力对性少数族裔妇女心理健康产生负面影响的机制。 具体而言，我们将测试应力敏感性炎症过程（C反应蛋白，IL-6，IL-10，， TNFA），不良适应性的情绪调节和认知过程（例如，反省；绝望）和 社会过程受损（社会隔离；浪漫关系功能）媒体之间的关联 少数派压力和心理健康。 （4）确定个人，社区和人际保护因素 少数族裔压力的不利心理健康影响的缓冲少数妇女。整个目标，项目 专注于确定可以针对干预措施的可变形因素，并且与当今年轻人有关 性少数妇女，种族，性别认同和特定的性取向身份。 调查结果将用于告知基于证据的，具有文化敏感的干预措施，以防止 并在这个脆弱的群体中治疗精神疾病。该提案对NOT-MD-19-001的反应（通知 对SGM人群健康研究的特殊兴趣），这鼓励研究描述 影响性别和性别少数群体健康（SGM）的生物学和社会过程，这将导致 开发干预措施以增强SGM健康。