DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS

高强度大孔生物材料的开发

• 批准号: 7535411
• 负责人: HUAKUN XU
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7535411
• 关键词: Affect; Age; Biocompatible Materials; Biomedical and Dental Materials; Blood Vessels; Bone Regeneration; Chitosan; Class; Clinical; Clinical Research; Defect; Dental; Dental Cements; Development; Equation; Excision; Fiber; Fracture; Generations; Goals; Immersion Investigative Technique; Implant; Length; Liquid substance; Mandible; Mannitol; Maxilla; Maxillary Ridge Augmentations; Methods; Microprocessor; Modeling; Nature; Population; Powder dose form; Principal Investigator; Procedures; Process; Property; Psychological reinforcement; Range; Rate; Recording of previous events; Research; Resistance; Shear Strength; Stress; Structure; Study models; System; Thick; Time; Trauma; Work; base; bone; calcium phosphate; clinical application; craniofacial repair; design; interfacial; knowledge base; novel; predictive modeling; programs; reconstruction; repaired; scaffold; text searching; tumor

DESCRIPTION (provided by applicant): The need for biomaterials has increased as the world population ages. Calcium phosphate cements (CPC) are highly promising for wide clinical applications due to their osteoconductivity and bone replacement capability.Their low strength, however, limits CPC to only non-stress uses. A literature search revealed no study on fiber reinforcement of CPC. In preliminary studies, the promise for CPC reinforcement was shown with a 2- to 5-fold increase in strength, 6-fold increase in fracture toughness, and two orders of magnitude increase in work-of-fracture. In this project, Aim 1 will use absorbable fibers to strengthen CPC and then to dissolve and create microprocessor vascular ingrowth; the effects of fiber length, volume fraction and fiber-matrix interface will be studied. Aim 2vill study the effects of changes in the absorbable fiber properties on the composite properties, and establish predictive equations. In Aim 3, CPC matrices with wide property ranges will be used to establish the relationships between matrix and composite properties. Non-rigid CPC, fast-dissolution CPC, flow able CPC and macroporous CPC will be studied; models on fundamental structure-property relationships will be determined. Aim 4 will investigate novel methods to control the macropore formation rate and tailor the strength history of the implant. Faster-absorbable fibers and slow-absorbable fibers will be combined in CPC for a high initial strength. Then the faster fibers dissolve and create macropores for bony ingrowth, while the slow fibers provide longer-term strength. Modeling will be performed to relate the composite property change to that of each fiber. In Aim 5, absorbable meshes will be used in CPC for strength and then highly interconnected macropores. The effects of mesh thickness and strength changes in immersion will be investigated and predictive equations will be established. Functionally graded multilayer implants will be investigated using mesh and fibers for controlled strength and macropore formation gradient. These studies will: 1) Yield novel composites for Dental and craniofacial repairs with superior strength, self-setting ability, scaffold structures, and capability of resorption and replacement by new bone; (it) Establish microstructural design methods for implants to achieve high strength and toughness with tailored strength history and macropore formation rates; (iii) Provide new reinforcement mechanisms, fundamental composite-constituent relationships, predictive models, and processing guidance to form the basis for a new generation of biomaterials.

描述（由申请人提供）：随着世界人口年龄的增长，对生物材料的需求增加了。磷酸钙水泥（CPC）对于广泛的临床应用而高度有望，因为它们的破骨性和骨骼替代能力。文献搜索没有发现有关CPC纤维增强的研究。在初步研究中，显示了CPC增强的希望，其强度增加了2至5倍，骨折韧性增加了6倍，而骨折工作增加了两个数量级。在这个项目中，AIM 1将使用可吸收纤维来增强CPC，然后溶解并创建微处理器血管内向。将研究纤维长度，体积分数和纤维矩阵界面的影响。 AIM 2Vill研究可吸收纤维性质变化对复合性质的影响，并建立预测方程。在AIM 3中，具有较大属性范围的CPC矩阵将用于建立矩阵和复合属性之间的关系。将研究非刚性CPC，快速下降CPC，流动能力CPC和大孔CPC；将确定有关基本结构特性关系的模型。 AIM 4将研究用于控制大孔形成速率并量身定制植入物的强度历史的新方法。可以在CPC中组合使用更快的可吸收纤维和慢速可吸收纤维，以具有很高的初始强度。然后，较快的纤维溶解并为骨质内部创建大孔，而缓慢的纤维可提供长期强度。将执行建模以将复合属性更改与每只光纤的更改相关联。在AIM 5中，可吸收网格将用于CPC的强度，然后高度相互连接的大孔。将研究网格厚度和浸入强度变化的影响，并建立预测方程。功能分级的多层植入物将使用网格和纤维进行控制强度和大孔形成梯度。这些研究将：1）产生具有优势强度，自我设定能力，脚手架结构的牙齿和颅面维修的新型复合材料以及新骨吸收和替代的能力； （IT）为植入物建立微观结构设计方法，以实现高强度和韧性，并使用量身定制的强度历史和大孔的形成率； （iii）提供了新的增强机制，基本的复合构成关系，预测模型和处理指南，以构成新一代生物材料的基础。