Biomechanics Core Facility

生物力学核心设施

• 批准号: 8380799
• 负责人: JOSEPH M MANSOUR
• 金额: $ 7.86万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8380799
• 关键词: Adhesions; Anabolism; Area; Biomechanics; Body Weight; Bone Matrix; Calcified; Cartilage; Characteristics; Chondrocytes; Complex; Core Facility; Data Analyses; Engineering; Environment; Evaluation; Fracture; Friction; Health; Hip region structure; Image; Investigation; Joints; Knee; Lead; Liquid substance; Literature; Materials Testing; Measures; Mechanics; Methods; Modeling; Morphology; Normal tissue morphology; Permeability; Property; Protocols documentation; Research Personnel; Surface; Testing; Time; Tissue Engineering; Tissues; Weight-Bearing state; articular cartilage; base; bone; cartilage repair; experience; joint loading; mechanical behavior; repaired; response; scaffold; theories; tissue repair

Articular cartilage functions as a bearing surface in freely moving joints such as hip and knee. It provides a low friction surface with excellent wear characteristics, it helps to distribute joint contact loads over a larger area than would be present if there was bone-to-bone contact, and it performs these functions while loaded at several times body-weight. Tissue engineered cartilage must be able to perform the same mechanical functions as native tissue. The Biomechanics Core Facility will provide material testing and general biomechanical expertise for evaluation of tissue-engineered constructs. Material properties will be determined using widely accepted test methods and models. Functional aspects of the repair will be investigated using specialized tests. In addition to supporting PROJECTS I, II, and III, biomechanical investigations will benefit from imaging capabilities of the Morphology core.

关节软骨在自由运动的关节（如髋关节和膝关节）中起支承表面的作用。它提供了一个低摩擦表面，具有优异的磨损特性，有助于将关节接触载荷分布在比骨与骨接触时更大的区域上，并且在承受数倍于体重的载荷时执行这些功能。组织工程软骨必须能够执行相同的 具有天然组织的机械功能。 生物力学核心机构将为组织工程结构的评价提供材料试验和一般生物力学专业知识。材料特性将使用广泛接受的测试方法和模型来确定。修复的功能方面将使用专门的测试进行调查。除了支持项目I、II和III，生物力学研究将受益于 形态学核心。