FASEB SRC on RETINOIDS

描述（由申请人提供）：本申请请求对将于2012年6月5日至12日在科罗拉多斯诺马斯的斯诺马斯度假村举行的第16届美国实验生物学学会联合会（FASEB）维甲酸夏季研究会议的部分支持。这个一年两次的研究会议已经非常好地参加（从100到200与会者在过去的25年），仍然是唯一的主要国家和国际会议，解决类维生素A生物学的全谱。在过去的二十年里，我们对类维生素A的作用机制和生物学功能的理解迅速增加。然而，关于维甲酸在正常人体生理学和病理生理学中的作用，还有很多需要了解的。为了满足这种信息需求，有大量正在进行的研究活动集中在类维生素A上，其中大部分由NIH支持（NIH CRISP数据库显示，目前有284项NIH资助的申请涉及类维生素A生物学）。2012年会议将包括一个全体演讲，平台介绍和海报会议，将允许科学与会者之间的新研究成果的交流。会议将讨论的主要议题包括：（1）类维生素A化学;（2）类维生素A和类胡萝卜素代谢酶;（3）类维生素A受体;（4）类维生素A的基因组作用;（5）类维生素A稳态和信号传导;（6）类维生素A在发育和免疫中的作用;（7）类维生素A在癌症和分化控制中的作用;（8）类维生素A在代谢性疾病中的作用;（9）类维生素A在代谢性疾病中的作用。（9）眼内类维生素A。拟议中的类维生素A会议的总体目标是召集一组研究人员（包括资深科学家， 职业中期的科学家，初级科学家，博士后研究员和研究生）谁在不同的学科工作（作为生物化学家，分子生物学家，营养科学家，癌症研究人员，发育生物学家，视觉研究人员，细胞生物学家，生物药理学家，结构生物学家，免疫学家，化学家和临床医生）介绍和讨论他们的最新研究发现，共同关注类维生素A。本次会议将为最近的研究和新的研究思路和合作的发展提供一个论坛。这将刺激新的调查，及时提供 需要深入了解类维生素A在预防疾病和维持健康方面的基本作用。 公共卫生相关性：类维生素A是维生素A的活性形式，对人类健康的许多方面具有广泛的影响，包括视力，胚胎发育，免疫力和多种细胞类型的分化。类维生素A是皮肤病和癌症的重要治疗剂，并且它们涉及糖尿病和肥胖症以及某些眼部疾病。两年一度的FASEB维甲酸夏季研究会议提供了唯一的主要国家和国际论坛，涉及维甲酸生物学的全方位。其目标是促进科学交流和新的研究，为类维生素A在疾病预防和治疗中的作用提供必要的见解。

DESCRIPTION (provided by applicant): This application requests partial support for the 16th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at the Snowmass Resort in Snowmass, Colorado on June 5-12, 2012. This bi-annual research conference has been very well attended (ranging from 100 to 200 attendees over the past 25 years) and remains the sole major national and international conference that addresses the full spectrum of retinoid biology. Our understanding of the mechanisms of action and the biological functions of retinoids has increased rapidly over the last two decades. Nevertheless, there is much that still needs to be learned regarding retinoid actions in both normal human physiology and pathophysiology. To meet this need for information, there is a great deal of ongoing research activity focused on the retinoids, much of it supported by the NIH (the NIH CRISP database indicates that there are currently 284 funded NIH applications involving retinoid biology). The 2012 conference will consist of a plenary lecture, platform presentations and poster sessions that will allow for the exchange of new research findings amongst scientific attendees. The main topics to be addressed at the conference include: (1) retinoid chemistry; (2) retinoid & carotenoid metabolizing enzymes; (3) retinoid receptors; (4) genomic actions of retinoids; (5) retinoid homeostasis & signaling; (6) retinoids in development & immunity; (7) retinoids in cancer & control of differentiation; (8) retinoids in metabolic disease; and (9) retinoids in the eye. The overall goal of the proposed conference on retinoids is to bring together a group of investigators (including senior scientists, mid-career scientists, junior scientists, postdoctoral fellows, and graduate students) who work in diverse disciplines (as biochemists, molecular biologists, nutritional scientists, cancer researchers, developmental biologists, vision researchers, cell biologists, biophysicists, structural biologists, immunologists, chemists, and clinicians) to present and discuss their newest research finding that share a common focus on the retinoids. This conference will provide a forum for the critical review of recent research and for the development of new research ideas and collaborations. This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining health. PUBLIC HEALTH RELEVANCE: Retinoids, the active forms of vitamin A, have wide ranging effects on many aspects of human health including vision, embryonic development, immunity, and differentiation of diverse cell types. Retinoids are important therapeutics for skin disorders and cancer, and they are involved in diabetes and obesity and certain ocular diseases. The bi-annual FASEB Summer Research Conference on Retinoids provides the sole major national and international forum that addresses the full spectrum of retinoid biology. Its goal is to stimulate scientific exchange and new investigations that will provide needed insights into the roles of retinoids in disease prevention and treatment.