FASEB SRC on RETINOIDS

FASEB SRC 关于类维生素A

• 批准号: 8318363
• 负责人: EARL Howard HARRISON
• 金额: $ 2.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318363
• 关键词: Address; American; Biochemical; Biological Process; Biology; Cancer Control; Carotenoids; Cells; Chemistry; Clinical; Collaborations; Colorado; Computer Retrieval of Information on Scientific Projects Database; Databases; Development; Diabetes Mellitus; Discipline; Disease; Embryonic Development; Enzymes; Eye; Functional disorder; Funding; Genomics; Goals; Health; Homeostasis; Human; Immunity; Immunologist; International; Investigation; Learning; Malignant Neoplasms; Metabolic Diseases; Molecular; Nutritional; Obesity; Physiological; Physiology; Postdoctoral Fellow; Request for Applications; Research; Research Activity; Research Personnel; Resort; Retinoid Receptor; Retinoids; Role; Scientist; Senior Scientist; Signal Transduction; Skin Cancer; Societies; Structural Biologist; Therapeutic; Time; United States National Institutes of Health; Vision; Vitamin A; Work; abstracting; bench to bedside; career; cell type; disorder prevention; graduate student; insight; lectures; meetings; posters; prevent; research and development; skin disorder; symposium

DESCRIPTION (provided by applicant): This application requests partial support for the 16th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at the Snowmass Resort in Snowmass, Colorado on June 5-12, 2012. This bi-annual research conference has been very well attended (ranging from 100 to 200 attendees over the past 25 years) and remains the sole major national and international conference that addresses the full spectrum of retinoid biology. Our understanding of the mechanisms of action and the biological functions of retinoids has increased rapidly over the last two decades. Nevertheless, there is much that still needs to be learned regarding retinoid actions in both normal human physiology and pathophysiology. To meet this need for information, there is a great deal of ongoing research activity focused on the retinoids, much of it supported by the NIH (the NIH CRISP database indicates that there are currently 284 funded NIH applications involving retinoid biology). The 2012 conference will consist of a plenary lecture, platform presentations and poster sessions that will allow for the exchange of new research findings amongst scientific attendees. The main topics to be addressed at the conference include: (1) retinoid chemistry; (2) retinoid & carotenoid metabolizing enzymes; (3) retinoid receptors; (4) genomic actions of retinoids; (5) retinoid homeostasis & signaling; (6) retinoids in development & immunity; (7) retinoids in cancer & control of differentiation; (8) retinoids in metabolic disease; and (9) retinoids in the eye. The overall goal of the proposed conference on retinoids is to bring together a group of investigators (including senior scientists, mid-career scientists, junior scientists, postdoctoral fellows, and graduate students) who work in diverse disciplines (as biochemists, molecular biologists, nutritional scientists, cancer researchers, developmental biologists, vision researchers, cell biologists, biophysicists, structural biologists, immunologists, chemists, and clinicians) to present and discuss their newest research finding that share a common focus on the retinoids. This conference will provide a forum for the critical review of recent research and for the development of new research ideas and collaborations. This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining health. PUBLIC HEALTH RELEVANCE: Retinoids, the active forms of vitamin A, have wide ranging effects on many aspects of human health including vision, embryonic development, immunity, and differentiation of diverse cell types. Retinoids are important therapeutics for skin disorders and cancer, and they are involved in diabetes and obesity and certain ocular diseases. The bi-annual FASEB Summer Research Conference on Retinoids provides the sole major national and international forum that addresses the full spectrum of retinoid biology. Its goal is to stimulate scientific exchange and new investigations that will provide needed insights into the roles of retinoids in disease prevention and treatment.

描述（由申请人提供）：该申请要求为2012年6月5日至12日在科罗拉多州雪雪地的Snowmass Resort举行的实验生物学联合会（FASEB）夏季研究会议的第16届美国社会联合会（FASEB）夏季研究会议，2012年6月5日至12日，这次每两年一次的研究会议都非常愉快（在100到200年的参与者中，及其在200年的时间表都及其范围，该国的整个会议及其群体及其群体的整体及其范围是大会的，这是该范围的主要范围。维生素生物学。在过去的二十年中，我们对视力素的作用机理和维生素的生物学功能的理解迅速增加。然而，在正常的人类生理学和病理生理学中，仍然需要学习很多关于类维生素类动作的知识。为了满足对信息的需求，有很多持续的研究活动集中在类视网膜类似的情况下，其中大部分由NIH支持（NIH CRISP数据库表明目前有284个资助的NIH涉及视网膜生物学的NIH应用程序）。 2012年会议将包括全体演讲，平台演示和海报会议，该会议将允许在科学与会者中交换新的研究结果。会议上要解决的主要主题包括：（1）类维生素性化学； （2）类类类和类胡萝卜素代谢酶； （3）类视黄素受体； （4）类视黄素的基因组作用； （5）类维生素性稳态和信号传导； （6）开发与免疫的类视黄素； （7）癌症和分化控制中的类视黄素； （8）代谢性疾病中的类视黄素； （9）眼睛中的类视黄素。拟议的类维生素类似会议的总体目标是将一组调查人员汇集在一起​​（包括高级科学家，包括高级科学家， 职业中学科学家，初级科学家，博士后研究员和研究生）在多样化的学科中（作为生物化学家，分子生物学家，营养学家，营养科学家，癌症研究人员，发展生物学家，视觉研究人员，视线研究人员，生物学家，生物物理学家，生物物理学家，结构生物学家，临床学家，化学主义者，化学主义者，化学家，化学研究员，化学研究人员，化学研究人员，化学研究人员，化学研究人员，化学研究人员，化学研究人员，化学研究人员，化学研究人员）视网膜类似。这次会议将为对最新研究的批判性审查以及新的研究思想和合作的发展提供论坛。这将刺激新调查，及时提供 需要深入了解性类维生素性在预防疾病和维持健康方面的基本作用。 公共卫生相关性：维生素A的主动形式的类维生素A对人类健康的许多方面具有广泛的影响，包括视觉，胚胎发育，免疫力和各种细胞类型的差异化。类维生素类动物是皮肤疾病和癌症的重要疗法，它们参与糖尿病和肥胖症以及某些眼部疾病。每两年的VaseB类维生素类动物研究会议提供了唯一的主要国家和国际论坛，该论坛介绍了整个类维生素生物学的范围。它的目标是刺激科学交流和新的研究，这些研究将为类视视视网想中疾病预防和治疗的作用提供必要的见解。