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9th International Podocyte Conference

第九届国际足细胞会议

基本信息

批准号：
8317085
负责人：
Stuart James Shankland
金额：
$ 1.3万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-05 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8317085
关键词：
Accounting Actinin Actins Adherens Junction Adult Albumins Applications Grants Basement membrane Biology Blood capillaries Bowman&apos s space CD29 Antigen Caliber Cardiovascular Diseases Cells Characteristics Charge Child Chronic Clinical Clinical Research Complex Contractile Proteins Contractile System Detection Development Diabetes Mellitus Diagnosis Disease Endothelial Cells Epithelial Cells Epithelium Fibroblasts Financial Support Focal Adhesions Focal Segmental Glomerulosclerosis Foot Process Glomerular capsule structure Glycocalyx Goals Incidence Injury Injury to Kidney Intercellular Junctions International Kidney Kidney Diseases Knowledge Left Literature Membranous Glomerulonephritis Microfilaments Minor Morbidity - disease rate Myosin Type II NPHS2 protein Nephrotic Syndrome P-Cadherin Parietal Patients Pericytes Phenotype Prevalence Proteins Proteinuria Renal glomerular disease Reporting Research Risk Factors Severities Severity of illness Shapes Structure Syndrome Talin United States National Institutes of Health Vinculin Visceral Writing burden of illness capillary cell type glomerular basement membrane improved injury and repair kidney epithelial cell macromolecule meetings mesangial cell mortality nephrin neuronal cell body outcome forecast podocyte prevent repaired slit diaphragm symposium synaptopodin

项目摘要

DESCRIPTION (provided by applicant): The glomerular podocyte is a terminally differentiated and highly specialized kidney epithelial cell. In addition to providing structural support to the glomerulus, its main function is to limit the passage of protein from the intravascular space to the urinary space. Thus, the clinical signature of injury to podocytes is proteinuria. Injury occur in diabetes, membranous nephropathy, focal segmental glomerulosclerosis and minimal change disease. This R13 applicant application is written to support the the 9th International Podocyte Conference, the major goal of which is to substantially advance the clinical and research aspects of podocyte diseases. PUBLIC HEALTH RELEVANCE: Injury to kidney podocytes is the leading cause of proteinuria, which is an independent risk factor for cardiovascular disease. Improving our understanding of injury and repair will reduce the overall burden of disease.

描述（由申请人提供）：肾小球足细胞是终末分化和高度特化的肾脏上皮细胞。除了为肾小球提供结构支持外，其主要功能是限制蛋白质从血管内空间进入泌尿空间。因此，足细胞损伤的临床特征是蛋白尿。损伤发生在糖尿病、膜性肾病、局灶性节段性肾小球硬化和微小病变疾病中。此R13申请人申请旨在支持第9届国际足细胞会议，其主要目标是大幅推进足细胞疾病的临床和研究方面。公共卫生相关性：肾足细胞损伤是蛋白尿的主要原因，蛋白尿是心血管疾病的独立危险因素。提高我们对损伤和修复的理解将减少疾病的总体负担。