Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans

发现 α-actinin-3 缺乏对人类运动训练肌肉适应的影响

• 批准号: DE140100864
• 负责人: Prof Nir Eynon
• 金额: $ 27.57万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-05-15 至 2017-05-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140100864
• 关键词: Discovering; Effect; alpha; actinin; Deficiency

The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This project will demonstrate the effects of alpha-actinin-3 deficiency on the characteristics of human muscle pre and post exercise training. Outcomes will include major applications for personalising health recommendations and in designing preventative programs for ageing.

蛋白α-肌动蛋白3在快速肌肉纤维中表达。一种常见的基因变异会导致α-肌动蛋白3的完全缺乏，这已被证明会影响运动表现。先前已经生成了小鼠模型，以证明α-肌动蛋白3缺乏会导致快速肌肉纤维的显着转移，从而向缓慢，更有效的肌肉纤维降低。该项目将证明α-肌动蛋白3缺乏对运动前和运动后肌肉特征的影响。成果将包括个性化健康建议和设计预防衰老计划的主要应用程序。