Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans

发现 α-actinin-3 缺乏对人类运动训练肌肉适应的影响

• 批准号: DE140100864
• 负责人: Prof Nir Eynon
• 金额: $ 27.57万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-05-15 至 2017-05-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140100864
• 关键词: Discovering; Effect; alpha; actinin; Deficiency

The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This project will demonstrate the effects of alpha-actinin-3 deficiency on the characteristics of human muscle pre and post exercise training. Outcomes will include major applications for personalising health recommendations and in designing preventative programs for ageing.

肌动蛋白-3在快肌纤维中表达。一种常见的基因变异会导致α -肌动蛋白-3的完全缺乏，而α -肌动蛋白-3已被证明会影响运动表现。先前已经建立了一个小鼠模型来证明-肌动蛋白-3缺乏会导致快速肌纤维向慢速、更高效的肌纤维的显著转变。本项目将论证α -肌动素-3缺乏对人体肌肉运动训练前后特性的影响。结果将包括个性化健康建议和设计老龄化预防方案的主要应用。