Angiotensin Metabolite Formation by Podocytes: Implications in Glomerular Injury

描述（由申请人提供）： 这是一个新的K 08应用程序，其目的是为候选人Juan卡洛斯Q博士提供培训和指导研究环境。Velez，来自南卡罗来纳州医科大学。MUSC是南卡罗来纳州最大的医疗综合体的一部分，拥有140，000平方英尺的研究实验室空间和一个多学科的大学研究资源设施（URRF），其中包含可供研究人员使用的共享资源，包括：高级图像分析;基因靶向和敲除小鼠设施;核磁共振设施和一个已建立的质谱设施。 候选人这位候选人是MUSC肾脏科的一位新的全职终身助理教授。他是一位崭露头角的年轻临床科学家，在他的早期职业生涯中获得了两项基础科学研究奖项，最近在一份着名的同行评审期刊上发表了一篇第一作者论文。他拥有非常适合KO 8赞助的专业素质。Velez博士概述了一项计划，以建立一个成功的独立资助的实验室，并获得必要的经验，以保持与肾脏研究相关的富有成效的科学事业。为了确保实现这些目标，Velez博士组建了一个高素质的指导委员会，由在获得校外资金和维持成功的研究实验室方面有着广泛记录的科学家组成。 研究提案。该提案旨在包括一系列重点假设驱动的实验，这些实验将深入了解肾小球内激素调节的机制及其与导致进行性肾脏疾病的途径的关系。具体而言，该提案的重点是检查肾小球内血管紧张素II和其他血管紧张素代谢产物之间的平衡，以及肾小球足细胞在该系统中发挥的作用。研究计划的目标是建立一个技术知识和专业知识的基础，通过它可以建立一个长期的研究计划。 公共卫生相关性：本文概述的研究将增加对肾脏内现有机制的理解，以平衡激素血管紧张素II的作用。两千万美国人患有慢性肾脏疾病，还有许多人面临着患上慢性肾脏疾病的风险，药物阻断血管紧张素II是FDA唯一批准的治疗方法。尽管接受了这种治疗，仍有相当比例的受影响患者继续进展到疾病的终末期形式。更好地了解肾脏中的机制应该会导致可以直接靶向的治疗。这些疗法将改善受影响个体的生活质量和寿命。

DESCRIPTION (provided by applicant): This is a new K08 application, the purpose of which is to provide training and a mentored research environment for the candidate, Dr. Juan Carlos Q. Velez, at the Medical University of South Carolina. MUSC is part of South Carolina's largest medical complex with 140,000 ft2 dedicated to research laboratory space and a multidisciplinary University Research Resource Facility (URRF) that contains shared resources available to investigators including: Advanced Image Analysis; Gene targeting and Knockout Mouse Facility; Nuclear Magnetic Resonance Facility, and an established Mass Spectrometry Facility. Candidate. The candidate is a new full-time tenure-track assistant professor in the Division of Nephrology, at the MUSC. He is an up-and-coming young clinician-scientist that has a track record of two awards in basic science research during his early career and one recent first-author publication in a prestigious peer-reviewed journal. He possesses professional qualities highly suited for KO8 sponsorship. Dr. Velez has outlined a plan to develop a successful independently funded laboratory and to gain experience necessary to maintain a productive scientific career relevant to kidney research. To ensure these goals are met, Dr. Velez has assembled a highly qualified mentorship committee of scientists who have extensive track records in obtaining extramural funding and maintaining successful research laboratories. Research Proposal. The proposal has been designed to include a focused hypothesis-driven series of experiments that will yield insight into mechanisms of hormonal regulation within the kidney glomerulus and their relationship with pathways that lead to progressive kidney diseases. Specifically, the proposal is focused on examining the balance between intraglomerular angiotensin-II and other angiotensin metabolites and the role that glomerular podocytes play in that system. The goal of the research proposal is to establish a foundation of technical knowledge and expertise by which a long-term research program can be established. PUBLIC HEALTH RELEVANCE: The studies outlined herein will add to the understanding of the existing mechanisms within the kidney to counterbalance the actions of the hormone angiotensin-II. Twenty million American have chronic kidney disease and many others are on risk of acquiring it. Pharmacological blockade of angiotensin-II constitutes the only FDA-approved therapy available. Despite receiving this therapy, a significant percentage of the affected patients continue to progress to the end-stage form of the disease. Better understanding of the mechanisms of in the kidney should lead to therapies that can directly target. These therapies would improve both quality and length of life of affected individuals.