Basic HIV and HIV/AIDS-related Diseases Science Training Program for Uganda

乌干达基本艾滋病毒和艾滋病毒/艾滋病相关疾病科学培训计划

• 批准号: 8710853
• 负责人: W. Henry Boom
• 金额: $ 28.86万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-27 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710853
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Basic Science; Biochemical; Biomedical Research; Cardiovascular Diseases; Clinical; Clinical Research; Collaborations; Communities; Country; Development; Disease; Doctor of Philosophy; Educational Status; Epidemic; Equilibrium; Faculty; Goals; Graduate Education; HIV; HIV-1; Health; Human; Immunology; Joints; Laboratories; Laboratory Scientists; Link; Malignant Neoplasms; Medical Microbiology; Mentors; Microbiology; Molecular; Opportunistic Infections; Research; Research Infrastructure; Research Training; Role; Science; Scientist; Societies; Technology; Training; Training Programs; Training and Education; Translational Research; Tuberculosis; Uganda; Universities; base; experience; innovation; meetings; programs

The focus and goal of this new Basic HIV and HIV/AIDS-related Diseases Science Training Program for Uganda (or BHSTP) is to meet the basic and translational science shortcomings in the Ugandan scientific community in regards to research questions specific to the HIV, HIV-associated diseases such malignancies, opportunistic infections (e.g. tuberculosis or TB), and cardiovascular disease in Uganda. This will be achieved through longstanding collaborations between Case Western Reserve University (CWRU), Makerere University and the Joint Clinical Research Centre (JCRC). The overall goal of this training program is to build long-term, sustainable laboratory-based research capacity in Uganda by educating and promoting independent basic/translational scientists. The following aims are proposed: 1. To strengthen Ugandan biomedical research capacity at the faculty level by supporting PhD level training in microbiology and immunology at CWRU of talented young Ugandan scientists who have completed Masters level training in Uganda. 2. To strengthen graduate education in biomedical sciences in Uganda by supporting Masters level training in the Department of Microbiology at Makerere University. 3. To establish regional expertise on HIV and HIV-related diseases by building on the infrastructure and ongoing research of the Uganda-CWRU Research Collaboration. 4. To develop a culture of mentoring of young and developing laboratory scientists through the Uganda Society of Health Scientists. 5. To continue close collaborations between this BHSTP and the clinical laboratories at the JCRC and Makerere University in order to provide the most advanced facilities for molecular, cellular, and biochemical research in Uganda. To address the specific aims of this proposal, we propose a coherent, multi-disciplinary program of education and training in degree and non-degree experiences at CWRU and in Uganda, that addresses the changing circumstances imposed by the HIV epidemic and that builds on 20+ years of training and human capacity development in Uganda through the ending AITRP program. The proposed program is balanced with Masters level training in Uganda and Ph.D. training at CWRU. In order to advance the Masters programs in Medical Microbiology at Makerere, 2 state-of-the-art courses will be offered (years 1, 2, 4, 5) in Uganda on HIV-1 and AIDS-related diseases focused on latest innovations in basic science and technology. Nondegree training will include a mix of short and long-term training experiences. We will develop a monthly seminar that explores the role of mentoring in the biomedical sciences. These in-country activities will be coordinated through the Ugandan Society for Health Scientists. Research training in this program will be linked to and build upon the extensive infrastructure and portfolio in HIV, malignancies, cardiovascular disease, and TB research of the Uganda-CWRU Research Collaboration.

这一新的乌干达基本艾滋病毒和艾滋病毒/艾滋病相关疾病科学培训计划（或 BHSTP）的重点和目标是弥补乌干达科学界在艾滋病毒、艾滋病毒相关疾病（如恶性肿瘤、机会性感染（例如结核病或结核病）和心血管疾病）特定研究问题方面的基础和转化科学缺陷。这将通过凯斯西储大学 (CWRU)、麦克雷雷大学和联合临床研究中心 (JCRC) 之间的长期合作来实现。该培训计划的总体目标是通过教育和提升独立的基础/转化科学家，在乌干达建立长期、可持续的实验室研究能力。建议实现以下目标： 1. 通过支持在乌干达完成硕士水平培训的才华横溢的乌干达年轻科学家在 CWRU 进行微生物学和免疫学博士水平培训，加强乌干达教师水平的生物医学研究能力。 2. 通过支持麦克雷雷大学微生物学系的硕士水平培训，加强乌干达生物医学科学研究生教育。 3. 通过乌干达-CWRU 研究合作的基础设施和正在进行的研究，建立艾滋病毒和艾滋病毒相关疾病的区域专业知识。 4. 通过乌干达健康科学家协会发展一种指导年轻和发展中的实验室科学家的文化。 5. 继续本 BHSTP 与 JCRC 和麦克雷雷大学的临床实验室之间的密切合作，以便为乌干达的分子、细胞和生物化学研究提供最先进的设施。 为了实现该提案的具体目标，我们在 CWRU 和乌干达提出了一个连贯的、多学科的学位和非学位经验教育和培训计划，该计划应对艾滋病毒流行所造成的不断变化的环境，并以乌干达 20 多年的培训和人员能力发展为基础，通过结束 AITRP 计划。拟议的计划与乌干达的硕士水平培训和博士学位培训相平衡。 CWRU 培训。为了推进马凯雷雷大学医学微生物学硕士课程的发展，乌干达将开设 2 门最先进的课程（第 1、2、4、5 年），内容涉及 HIV-1 和艾滋病相关疾病，重点关注基础科学和技术的最新创新。非学位培训将包括短期和长期培训经验。我们将举办每月一次的研讨会，探讨指导在生物医学科学中的作用。这些国内活动将通过乌干达健康科学家协会进行协调。该计划的研究培训将与乌干达-CWRU 研究合作组织在艾滋病毒、恶性肿瘤、心血管疾病和结核病研究领域的广泛基础设施和投资组合相联系并建立在其基础上。

项目成果

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.

• DOI: 10.1371/journal.pone.0198091
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kigozi E;Kasule GW;Musisi K;Lukoye D;Kyobe S;Katabazi FA;Wampande EM;Joloba ML;Kateete DP
• 通讯作者: Kateete DP

Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering Ethinylestradiol/Levonorgestrel.

依非韦伦对联合使用炔雌醇/左炔诺孕酮的乌干达 HIV 感染妇女内源性黄体酮浓度和避孕结果的影响。

• DOI: 10.1155/2017/6531709
• 发表时间: 2017
• 期刊: AIDS research and treatment
• 影响因子: 1.7
• 作者: Munkwase,Grant;Bisaso,KuteesaR;Kakaire,Othman;Nanzigu,Sarah
• 通讯作者: Nanzigu,Sarah